{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:15:48Z","timestamp":1788243348420,"version":"build-2803163510"},"reference-count":21,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: The aim of this retrospective study was to characterize the preoperative hormonal, biochemical, and imaging features of adrenal lesions (ALs) and to assess differences in these features between benign and malignant lesions. Methods: This was a retrospective, single-center observational study conducted at the Endocrinology Clinic of Ankara Bilkent City Hospital. We reviewed the medical records of all patients referred to our clinic for the evaluation of an AL between February 2019 and August 2025. Demographic and clinical data and initial imaging were extracted from electronic medical records. Results: A total of 157 patients who underwent adrenalectomy were included in the analysis. Of these, 98 patients were female (62.4%) and 59 were male (37.6%). The mean age of the patients was 51.2 \u00b1 12.54 years. Functionally, the findings were pheochromocytoma (n:44), overt Cushing syndrome (n:17), mild autosomal cortisol secretion (n:29), primary hyperaldosteronism (n:18), and non-functional (n:47). One patient had pheochromocytoma and mild autosomal cortisol secretion, and one patient had overt Cushing syndrome and primary hyperaldosteronism. Of the adrenal lesions, 70 (44.6%) were on the right, 71 (45.2%) on the left, and 16 (10.2%) were bilateral. 9% (7\/79) of lesions measuring 4 cm and above, and 14% (4\/28) of lesions measuring 6 cm and above were found to be malignant. The malignancy rate was 22% (4\/18) in lesions located on the right and measuring 6 cm and above. All adrenocortical carcinomas were larger than 4 cm (8.3 \u00b1 3.46) and all were on the right. The highest-grade malignant epithelial tumor was 12.9 cm and on the right. The malignant pheochromocytoma was 5.2 cm and on the left. It was determined that the frequency of right adrenal localization was significantly higher in the malignant group (85.7%) compared to the benign group (42.7%) (p = 0.045). Right tumor diameter (p = 0.002) and right and\/or left tumor diameter (p &lt; 0.001) were significantly higher in malignant lesions compared to benign lesions. Logistic regression analysis also supported a significant relationship between tumor size and malignancy. Conclusions: In our study, 9% (7\/79) of lesions measuring 4 cm and above, and 14% (4\/28) of lesions measuring 6 cm and above were found to be malignant. The malignancy rate in lesions on the right side measuring 6 cm and above was determined to be 22% (4\/18). Although benign masses constituted the majority of lesions measuring 4 cm and above, all adrenocortical carcinomas were above 4 cm (8.3 \u00b1 3.46). In light of the current findings, tumor size was observed to be associated with the distinction between malignant and benign adrenal lesions and may be considered an important descriptive characteristic in the clinical assessment of adrenal lesions.<\/jats:p>","DOI":"10.3390\/diagnostics16172807","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:45:13Z","timestamp":1788241513000},"page":"2807","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From Detection to Decision: A Single-Center Analysis of Preoperative Imaging, Surgical Indications and Postoperative Histopathological Findings in Adrenal Lesions"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6790-3031","authenticated-orcid":false,"given":"Feride P\u0131nar","family":"Altay","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Ankara Bilkent City Hospital, Ankara 06800, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]},{"given":"\u015eefika Bur\u00e7ak","family":"Polat","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Faculty of Medicine, Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University, Ankara 06010, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1856-1263","authenticated-orcid":false,"given":"Sevg\u00fcl","family":"Fak\u0131","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Ankara Bilkent City Hospital, Ankara 06800, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5883-3545","authenticated-orcid":false,"given":"G\u00fcls\u00fcm","family":"Karaahmetli","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Ankara Bilkent City Hospital, Ankara 06800, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyla","family":"Akdo\u011fan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, K\u0131r\u0131kkale High Specialization Hospital, K\u0131r\u0131kkale 71450, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Oya","family":"Topalo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Faculty of Medicine, Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University, Ankara 06010, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7437-1176","authenticated-orcid":false,"given":"Reyhan","family":"Ersoy","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Faculty of Medicine, Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University, Ankara 06010, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Bekir","family":"\u00c7ak\u0131r","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Faculty of Medicine, Ankara Y\u0131ld\u0131r\u0131m Beyaz\u0131t University, Ankara 06010, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"resources","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"ref_1","unstructured":"Feingold, K.R., Ahmed, S.F., Anawalt, B., Blackman, M.R., Boyce, A., Chrousos, G., Corpas, E., de Herder, W.W., Dhatariya, K., and Dungan, K. (2024). Adrenal Incidentaloma. Endotext, MDText.com, Inc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"119833","DOI":"10.4329\/wjr.v18.i4.119833","article-title":"Evaluation of adrenal incidentalomas: Current approaches, caveats, and unexplored issues","volume":"18","author":"Kouroglou","year":"2026","journal-title":"World J. Radiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1093\/ejendo\/lvad066","article-title":"European Society of Endocrinology clinical practice guidelines on the management of adrenal incidentalomas, in collaboration with the European Network for the Study of Adrenal Tumors","volume":"189","author":"Fassnacht","year":"2023","journal-title":"Eur. J. Endocrinol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1210\/endrev\/bnaa008","article-title":"Adrenal Incidentaloma","volume":"41","author":"Sherlock","year":"2020","journal-title":"Endocr. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3803\/EnM.2017.32.2.200","article-title":"Korean Endocrine Society, Committee for Clinical Practice Guidelines. Clinical Guidelines for the Management of Adrenal Incidentaloma","volume":"32","author":"Lee","year":"2017","journal-title":"Endocrinol. Metab."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4158\/EP.15.S1.1","article-title":"American Association of Clinical Endocrinologists and American Association of Endocrine Surgeons Medical Guidelines for the Management of Adrenal Incidentalomas","volume":"15","author":"Zeiger","year":"2009","journal-title":"Endocr. Pract."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1001\/jamasurg.2022.3544","article-title":"American Association of Endocrine Surgeons Guidelines for Adrenalectomy: Executive Summary","volume":"157","author":"Yip","year":"2022","journal-title":"JAMA Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s12022-022-09710-8","article-title":"Overview of the 2022 WHO Classification of Adrenal Cortical Tumors","volume":"33","author":"Mete","year":"2022","journal-title":"Endocr. Pathol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1097\/00000478-198903000-00004","article-title":"Pathologic features of prognostic significance in adrenocortical carcinoma","volume":"13","author":"Weiss","year":"1989","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/ejendo\/lvae078","article-title":"Clinical and imaging presentations are associated with function in incidental adrenocortical adenomas: A retrospective cohort study","volume":"191","author":"Hamidi","year":"2024","journal-title":"Eur. J. Endocrinol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Remde, H., Kranz, S., Morell, S.M., Altieri, B., Kroiss, M., Detomas, M., Fassnacht, M., and Deutschbein, T. (2023). Clinical course of patients with adrenal incidentalomas and cortisol autonomy: A German retrospective single center cohort study. Front Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1123132"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/S2213-8587(20)30314-4","article-title":"Epidemiology of adrenal tumours in Olmsted County, Minnesota, USA: A population-based cohort study","volume":"8","author":"Ebbehoj","year":"2020","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"107","DOI":"10.7326\/M18-3630","article-title":"Natural history of adrenal incidentalomas with and without mild autonomous cortisol excess: A systematic review and meta-analysis","volume":"171","author":"Elhassan","year":"2019","journal-title":"Ann. Intern. Med."},{"key":"ref_14","first-page":"e92389","article-title":"Demographics, Clinical Profiles, and Outcomes of Patients With Adrenal Disorders in a Tertiary Care Center: A Retrospective Study","volume":"17","author":"Khan","year":"2025","journal-title":"Cureus"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e28160","DOI":"10.1016\/j.heliyon.2024.e28160","article-title":"Estimation of the tumor size at cure threshold among adult patients with adrenocortical carcinoma: A populational-based study","volume":"10","author":"Huang","year":"2024","journal-title":"Heliyon"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1530\/EJE-16-0467","article-title":"Management of adrenal incidentalomas: European Society of Endocrinology Clinical Practice Guideline in collaboration with the European Network for the Study of Adrenal Tumors","volume":"175","author":"Fassnacht","year":"2016","journal-title":"Eur. J. Endocrinol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"577","DOI":"10.4158\/EP09351.OR","article-title":"Change in adrenal mass size as a predictor of a malignant tumor","volume":"16","author":"Pantalone","year":"2010","journal-title":"Endocr. Pract."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jacr.2023.04.027","article-title":"Impact of Size Thresholds on the Diagnosis of Incidental Adrenal Lesions: A Systematic Reviewand Meta-Analysis","volume":"21","author":"Wilson","year":"2024","journal-title":"J. Am. Coll. Radiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/his.12283","article-title":"Distinguishing adrenal cortical carcinomas and adenomas: A study of clinicopathological features and biomarkers","volume":"64","author":"Wang","year":"2014","journal-title":"Histopathology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1148\/radiol.11100569","article-title":"Characterization of adrenal masses by using FDG PET: A systematic review and meta-analysis of diagnostic test performance","volume":"259","author":"Boland","year":"2011","journal-title":"Radiology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1210\/jc.2017-00254","article-title":"Performance of 18F-FDG PET\/CT in the Characterization of Adrenal Masses in Noncancer Patients: A Prospective Study","volume":"102","author":"Guerin","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/17\/2807\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:47:54Z","timestamp":1788241674000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/17\/2807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":21,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["diagnostics16172807"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics16172807","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]}}}