{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:16:07Z","timestamp":1788430567900,"version":"build-2803163510"},"reference-count":32,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea (NRF) grant funded by the Korea Government","doi-asserted-by":"publisher","award":["NRF-2022R1C1C1002705"],"award-info":[{"award-number":["NRF-2022R1C1C1002705"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea (NRF) grant funded by the Korea Government","doi-asserted-by":"publisher","award":["RS-2026-25477744"],"award-info":[{"award-number":["RS-2026-25477744"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Soonchunhyang University Research Fund"},{"id":[{"id":"https:\/\/ror.org\/03qjsrb10","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: We aimed to compare the diagnostic performances of planar bone scintigraphy and whole-body 360\u00b0 cadmium\u2013zinc\u2013telluride (CZT) bone single-photon emission computed tomography\/computed tomography (SPECT\/CT) in detecting bone metastasis in patients with small cell lung cancer (SCLC). Methods: We retrospectively evaluated two separate, non-randomized cohorts of 175 patients with SCLC who underwent staging bone scintigraphy, comprising 93 and 82 patients who underwent planar bone scintigraphy using a conventional dual-head gamma camera and whole-body bone SPECT\/CT using a full-ring 360\u00b0 CZT camera, respectively. Both imaging examinations were visually assessed and compared using patient- and lesion-based analyses of their diagnostic performances. Results: Whole-body bone SPECT\/CT showed fewer equivocal findings and almost perfect inter-reader agreement. On the patient-based analysis, whole-body bone SPECT\/CT demonstrated higher unadjusted observed diagnostic accuracy than planar bone scintigraphy (87.8% vs. 73.1%; p = 0.016), with higher observed sensitivity (79.2% vs. 53.3%), specificity (91.4% vs. 82.5%), positive predictive value (79.2% vs. 59.3%) and negative predictive value (91.4% vs. 78.8%). However, on a lesion-based analysis, whole-body bone SPECT\/CT exhibited a low sensitivity of 47.5%, with particularly low detection rates for spine and pelvic metastases (29.4%), despite showing higher observed sensitivity than planar bone scintigraphy (20.1%). Conclusions: In two separate retrospective cohorts of SCLC patients, whole-body bone SPECT\/CT showed higher unadjusted observed patients-based diagnostic performance than planar bone scintigraphy. However, its lesion-level sensitivity remained low, particularly in the spine and pelvis.<\/jats:p>","DOI":"10.3390\/diagnostics16172838","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T09:20:43Z","timestamp":1788427243000},"page":"2838","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Diagnostic Performance of Whole-Body 360\u00b0 CZT Bone SPECT\/CT and Planar Bone Scintigraphy in Detecting Bone Metastasis in Small Cell Lung Cancer"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7943-3807","authenticated-orcid":false,"given":"Sang Mi","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Soonchunhyang University Cheonan Hospital, 31 Suncheonhyang 6-gil, Dongnam-gu, Cheonan 31151, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6103-6830","authenticated-orcid":false,"given":"Su Jin","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, CHA Bundang Medical Center, CHA University School of Medicine, 59 Yatap-ro, Bundang-gu, Seongnam 13496, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]},{"given":"Ju Ock","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, 31 Suncheonhyang 6-gil, Dongnam-gu, Cheonan 31151, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"validation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Ki Hyun","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, 31 Suncheonhyang 6-gil, Dongnam-gu, Cheonan 31151, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"validation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7278-2214","authenticated-orcid":false,"given":"Nam Hun","family":"Heo","sequence":"additional","affiliation":[{"name":"Clinical Trial Center, Soonchunhyang University Cheonan Hospital, 31 Suncheonhyang 6-gil, Dongnam-gu, Cheonan 31151, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2697-3578","authenticated-orcid":false,"given":"Jeong Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Soonchunhyang University Cheonan Hospital, 31 Suncheonhyang 6-gil, Dongnam-gu, Cheonan 31151, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1001\/jama.2025.0560","article-title":"Small Cell Lung Cancer: A Review","volume":"333","author":"Kim","year":"2025","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.6004\/jnccn.2021.0058","article-title":"Small Cell Lung Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology","volume":"19","author":"Ganti","year":"2021","journal-title":"J. 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