{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T10:10:12Z","timestamp":1789035012503,"version":"build-2803163510"},"reference-count":11,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Ocular involvement in psoriatic disease is often underrecognized, particularly when inflammation affects posterior segments and remains undetectable on routine examination or conventional imaging modalities. We report a 38-year-old woman with palmoplantar psoriasis and psoriatic arthritis, characterized by ultrasound-confirmed dactylitis and inflammatory left hip pain, receiving methotrexate and guselkumab. Disease activity was low (DAPSA 7.6; CRP 5.8 mg\/L). She presented with increased intraocular pressure, progressive visual blurring, and headache of 8 months\u2019 duration, without a previous history of uveitis. Multimodal imaging was performed, including slit-lamp examination, grayscale B-mode ocular ultrasound, optical coherence tomography (OCT), and strain elastography. Slit-lamp examination and grayscale B-mode ultrasound were unremarkable, with no detectable vitreous echoes (grade 0). OCT demonstrated preserved retinal architecture with subtle hyperreflective vitreous dots in the right eye, compatible with low-grade vitreous cellularity, while the left eye was unremarkable. In contrast, strain elastography revealed increased stiffness and marked heterogeneity within the vitreous and periocular tissues, suggesting biomechanical alterations not detected by conventional structural imaging. These findings suggest biomechanical alterations compatible with possible inflammatory tissue remodeling. In our patient, strain elastography revealed biomechanical heterogeneity that was not apparent on conventional B-mode ultrasound. These findings should be considered hypothesis-generating and warrant further investigation in prospective controlled studies.<\/jats:p>","DOI":"10.3390\/diagnostics16182924","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T09:13:03Z","timestamp":1789031583000},"page":"2924","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biomechanical Vitreous Alterations Detected by Strain Elastography Beyond Conventional B-Mode Ultrasound in Psoriatic Disease"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1689-6705","authenticated-orcid":false,"given":"Jos\u00e9 Alexandre","family":"Mendon\u00e7a","sequence":"first","affiliation":[{"name":"Stricto Sensu Postgraduate Program in Health Sciences, Pontifical Catholic University of Campinas (PUC-Campinas), Campinas 13087-571, SP, Brazil"},{"name":"Ultrasonography\/Rheumatology Service, School of Life Sciences, Pontifical Catholic University of Campinas (PUC-Campinas), Campinas 13087-571, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel Alex Soares","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Stricto Sensu Postgraduate Program in Health Sciences, Pontifical Catholic University of Campinas (PUC-Campinas), Campinas 13087-571, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Gambero","sequence":"additional","affiliation":[{"name":"Stricto Sensu Postgraduate Program in Health Sciences, Pontifical Catholic University of Campinas (PUC-Campinas), Campinas 13087-571, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1167\/iovs.17-22971","article-title":"In vivo elasticity mapping of posterior ocular layers using acoustic radiation force optical coherence elastography","volume":"59","author":"Qu","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_2","first-page":"964","article-title":"Assessment of uveitis and complications by ultrasound in comparison with optical coherence tomography in psoriatic arthritis using etanercept","volume":"14","author":"Coelho","year":"2023","journal-title":"J. Clin. Exp. Ophthalmol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Herbort, C.P., Takeuchi, M., Papasavvas, I., Tugal-Tutkun, I., Hedayatfar, A., Usui, Y., Ozdal, P.C., and Urzua, C.A. (2023). Optical coherence tomography angiography (OCT-A) in uveitis: A literature review and a reassessment of its real role. Diagnostics, 13.","DOI":"10.3390\/diagnostics13040601"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1167\/tvst.11.1.3","article-title":"OCT Assisted Quantification of Vitreous Inflammation in Uveitis","volume":"11","author":"Liu","year":"2022","journal-title":"Transl. Vis. Sci. Technol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1002\/art.40568","article-title":"The eyes have it: A rheumatologist\u2019s view of uveitis","volume":"70","author":"Rosenbaum","year":"2018","journal-title":"Arthritis Rheumatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"71","DOI":"10.5152\/eurjrheum.2023.22054","article-title":"B-scan ultrasound evaluation for uveitis in inflammatory arthropathies: A systematic review","volume":"10","year":"2023","journal-title":"Eur. J. Rheumatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1136\/annrheumdis-2023-eular.1328","article-title":"POS0901 Can B-mode ocular ultrasound assess vitritis in patients with axial spondyloarthritis and psoriatic arthritis?","volume":"82","author":"Pedri","year":"2023","journal-title":"Ann. Rheum. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e81955","DOI":"10.34117\/bjdv11n9-020","article-title":"Ultrasound evaluation of uveitis in patients with psoriatic arthritis","volume":"11","author":"Pedri","year":"2025","journal-title":"Braz. J. Dev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.7150\/thno.18650","article-title":"Ultrasound elastography: Review of techniques and clinical applications","volume":"7","author":"Sigrist","year":"2017","journal-title":"Theranostics"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"813.e1","DOI":"10.1016\/j.crad.2019.06.008","article-title":"Evaluation of the optic nerve using strain and shear-wave elastography in pre-eclampsia","volume":"74","author":"Asal","year":"2019","journal-title":"Clin. Radiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"14311","DOI":"10.1364\/OE.456065","article-title":"Elasticity measurements of ocular anterior and posterior segments using optical coherence elastography","volume":"30","author":"Zhang","year":"2022","journal-title":"Opt. Express"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/18\/2924\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T09:32:49Z","timestamp":1789032769000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/18\/2924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,10]]},"references-count":11,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["diagnostics16182924"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics16182924","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,10]]}}}