{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:16:08Z","timestamp":1790000168425,"version":"4.0.1"},"reference-count":25,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: To compare the lesion detection rates of fluid-attenuated inversion recovery with fat saturation (FLAIR-FS) versus T2-weighted short tau inversion recovery (T2WI-STIR) and contrast-enhanced T1-weighted imaging (CE-T1WI) in detecting lesions across antibody-defined subtypes (AQP4-ON, MOG-ON, seronegative ON) and anatomic segments of optic neuritis (ON). Methods: Forty-two patients (56 eyes) aged 5\u201357 years with acute\/subacute optic neuritis underwent orbital MRI (T2WI-STIR, FLAIR-FS, and CE-T1WI). Two blinded neuroradiologists independently reviewed the images to assess lesion detectability and inter-observer reliability (kappa statistics). Generalized estimating equations (GEE) were used to account for within-patient correlation, with Bonferroni correction for pairwise comparisons. Results: FLAIR-FS demonstrated the highest detection rate (96.4%, 54\/56 eyes), numerically higher than T2WI-STIR (80.4%, 45\/56 eyes; corrected p = 0.051) and significantly higher than CE-T1WI (76.8%, 43\/56 eyes; corrected p = 0.006). Inter-observer agreement was highest for FLAIR-FS (\u03ba = 0.791), followed by CE-T1WI (\u03ba = 0.729) and T2WI-STIR (\u03ba = 0.681). In the posterior visual pathway, FLAIR-FS detected significantly more lesions than T2WI-STIR (corrected p = 0.024) and CE-T1WI (corrected p = 0.024). The Sequence \u00d7 ON subtype interaction was not significant (p = 0.158); descriptively, FLAIR-FS showed the highest detection rate across all subtypes. Conclusions: FLAIR-FS demonstrated the highest lesion detection rate among the three sequences, particularly in the posterior visual pathway. FLAIR-FS should be regarded as a useful complementary non-contrast sequence, particularly when gadolinium cannot be administered.<\/jats:p>","DOI":"10.3390\/diagnostics16183061","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:50:03Z","timestamp":1789995003000},"page":"3061","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Non-Contrast Fat-Saturated FLAIR MRI: Utility for Detecting Posterior and Seronegative-Associated Lesions in Optic Neuritis"],"prefix":"10.3390","volume":"16","author":[{"given":"Buhuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Radiology, 3rd Medical Center of Chinese PLA General Hospital, No. 69, Yongding Road, Haidian District, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuru","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Radiology, 3rd Medical Center of Chinese PLA General Hospital, No. 69, Yongding Road, Haidian District, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, 3rd Medical Center of Chinese PLA General Hospital, No. 69, Yongding Road, Haidian District, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuetao","family":"Mu","sequence":"additional","affiliation":[{"name":"Department of Radiology, 3rd Medical Center of Chinese PLA General Hospital, No. 69, Yongding Road, Haidian District, Beijing 100039, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1080\/08820538.2020.1866027","article-title":"MRI Characteristics of NMO, MOG and MS Related Optic Neuritis","volume":"35","author":"Winter","year":"2020","journal-title":"Semin. 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