{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:01:52Z","timestamp":1790226112590,"version":"4.1.0"},"reference-count":20,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background\/Objectives: This study evaluates whether saline infiltration during coaxial needle withdrawal reduces the incidence of pneumothorax (PTX) in CT-guided lung biopsies, potentially enhancing procedural safety. Methods: A retrospective analysis of 200 consecutive CT-guided core needle biopsies (18G) was conducted using our hospital\u2019s Radiology Department database. All procedures were performed between February 2022 and December 2024 by a single operator with 20 years of experience. Patients were divided into two groups: Group A (100 patients), receiving 10 mL of 0.9% saline solution during coaxial needle withdrawal, and Group B (100 patients), in whom no saline was infiltrated. Descriptive and inferential statistical analyses were used to assess the relationship between saline infiltration and the incidence of PTX. Results: PTX occurred in 24% of Group B patients versus 7% in Group A (p = 0.001). Multivariate analysis identified saline infiltration as a significant protective factor, even in high-risk patients (e.g., those with emphysema or in lateral decubitus). The odds ratio (OR = 0.18; 95% CI: 0.07\u20130.48) indicates that saline infiltration significantly reduces the risk of PTX. Conclusions: Infiltration of 10 mL of saline during coaxial needle withdrawal significantly reduces the incidence of PTX in CT-guided lung biopsies, offering a simple and effective strategy to enhance patient safety.<\/jats:p>","DOI":"10.3390\/diagnostics16193080","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:14:59Z","timestamp":1790097299000},"page":"3080","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["How Effective Is Saline Solution Infiltration During Coaxial Needle Withdrawal in Reducing the Incidence of Pneumothorax in CT-Guided Lung Biopsies?"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2974-4958","authenticated-orcid":false,"given":"Giulia","family":"Viviano","sequence":"first","affiliation":[{"name":"University Hospital of Parma, Via Gramsci 14, 43126 Parma, PR, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganyat Adenike Ralitsa","family":"Adebanjo","sequence":"additional","affiliation":[{"name":"University Hospital of Parma, Via Gramsci 14, 43126 Parma, PR, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Concari","sequence":"additional","affiliation":[{"name":"University Hospital of Parma, Via Gramsci 14, 43126 Parma, PR, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0877-4954","authenticated-orcid":false,"given":"Chiara","family":"Martini","sequence":"additional","affiliation":[{"name":"University Hospital of Parma, Via Gramsci 14, 43126 Parma, PR, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5971-2040","authenticated-orcid":false,"given":"Giuseppe","family":"Pedrazzi","sequence":"additional","affiliation":[{"name":"University Hospital of Parma, Via Gramsci 14, 43126 Parma, PR, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2191-240X","authenticated-orcid":false,"given":"Miltos","family":"Krokidis","sequence":"additional","affiliation":[{"name":"Areteion Hospital, National and Kapodistrian University of Athens, 76, Vas. Sophias Ave, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3531-8858","authenticated-orcid":false,"given":"Massimo","family":"De Filippo","sequence":"additional","affiliation":[{"name":"University Hospital of Parma, Via Gramsci 14, 43126 Parma, PR, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1001\/jama.2021.24287","article-title":"Evaluating the Patient with a Pulmonary Nodule: A Review","volume":"327","author":"Mazzone","year":"2022","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1097\/JTO.0000000000000630","article-title":"The 2015 World Health Organization classification of lung tumors","volume":"10","author":"Travis","year":"2015","journal-title":"J. Thorac. 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