{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:04:27Z","timestamp":1790240667373,"version":"4.1.0"},"reference-count":9,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Recognizable radiographic signs aid in the differential diagnosis of skeletal dysplasias. Spondyloepiphyseal dysplasia congenita (SEDC), a COL2A1-related disorder, presents with characteristic but sometimes subtle pelvic changes in early childhood. To propose a novel pelvic radiographic sign observed in children with SEDC, we reviewed pelvic radiographs of a cohort of molecularly confirmed SEDC patients and noticed that the inferior contour of the ilium forms a continuous line resembling a flying dove, composed of the inner spur (resembling the dove\u2019s beak), formed by the inferior contour of the iliac part of the sciatic notch, sharply angled to the most medial contour of the iliac part of triradiate cartilage, convex line (resembling the dove\u2019s breast) composed of the lateral segment of the triradiate cartilage and medial segment of the acetabulum, and outer spur (resembling the junction between the body and wing) corresponding to the lateral part of the acetabulum and acetabular edge. The \u201cdove drawing\u201d sign may serve as an additional diagnostic clue for recognition of SEDC on pelvic radiographs, especially in children.<\/jats:p>","DOI":"10.3390\/diagnostics16193094","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:06:37Z","timestamp":1790237197000},"page":"3094","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The \u201cDove Drawing\u201d Appearance of the Ilium in Spondyloepiphyseal Dysplasia Congenita: A Proposed Radiographic Sign"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7651-8485","authenticated-orcid":false,"given":"Vladimir","family":"Kenis","sequence":"first","affiliation":[{"name":"H. Turner National Medical Research Center for Children\u2019s Orthopedics and Trauma Surgery, Parkovaya 64\u201368, Pushkin, 196603 St. Petersburg, Russia"},{"name":"North-Western State Medical University Named After I.I. Mechnikov, 191015 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1373-8277","authenticated-orcid":false,"given":"Yuko","family":"Tsujioka","sequence":"additional","affiliation":[{"name":"Department of Radiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku 160-8583, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Radiology, Musashino-Yowakai Hospital, 2-1-33 Midoricho, Musashino 180-0012, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2672-6294","authenticated-orcid":false,"given":"Tatiana","family":"Markova","sequence":"additional","affiliation":[{"name":"Department of Radiology, Musashino-Yowakai Hospital, 2-1-33 Midoricho, Musashino 180-0012, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeniy","family":"Melchenko","sequence":"additional","affiliation":[{"name":"H. Turner National Medical Research Center for Children\u2019s Orthopedics and Trauma Surgery, Parkovaya 64\u201368, Pushkin, 196603 St. Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Gorodilova","sequence":"additional","affiliation":[{"name":"Research Centre for Medical Genetics, Moskvorechye St., 1, 115522 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.5334\/jbr-btr.1389","article-title":"Helpful Signs in the Imaging Diagnosis of Hereditary Musculoskeletal Disease","volume":"101","author":"Vanhoenacker","year":"2017","journal-title":"J. Belg. Soc. Radiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s12098-015-1919-8","article-title":"The Radiograph of the Pelvis as a Window to Skeletal Dysplasias","volume":"83","author":"Gajarajulu","year":"2016","journal-title":"Indian J. Pediatr."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Markova, T., Kenis, V., Melchenko, E., Osipova, D., Nagornova, T., Orlova, A., Zakharova, E., Dadali, E., and Kutsev, S. (2022). Clinical and Genetic Characteristics of COL2A1-Associated Skeletal Dysplasias in 60 Russian Patients: Part I. Genes, 13.","DOI":"10.3390\/genes13010137"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Spranger, J.W., Brill, P.W., Hall, C., Nishimura, G., Superti-Furga, A., and Unger, S. (2018). Bone Dysplasias: An Atlas of Genetic Disorders of Skeletal Development, Oxford University Press. [4th ed.].","DOI":"10.1093\/med\/9780190626655.001.0001"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Kenis, V., Markova, T., Melchenko, E., and Gorodilova, D. (2026). Multiple Ossification Centers of the Pubic Bone as a Supportive Radiographic Feature for COL2A1-Related Congenital Spondyloepiphyseal Dysplasia. Diagnostics, 16.","DOI":"10.3390\/diagnostics16131955"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/ajmg.a.31516","article-title":"COL2A1-related skeletal dysplasias with predominant metaphyseal involvement","volume":"143A","author":"Walter","year":"2007","journal-title":"Am. J. Med. Genet. Part A"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1148\/rg.2021200075","article-title":"Radiologic Features of Type II and Type XI Collagenopathies","volume":"41","author":"Handa","year":"2021","journal-title":"Radiographics"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"17","DOI":"10.17816\/PTORS114730","article-title":"Principles of the differential diagnosis of achondroplasia and pseudoachondroplasia","volume":"11","author":"Markova","year":"2023","journal-title":"Pediatr. Traumatol. Orthop. Reconstr. Surg."},{"key":"ref_9","first-page":"45","article-title":"Broad spectrum of skeletal malformation complex in patients with cleidocranial dysplasia syndrome: Radiographic and tomographic study","volume":"6","author":"Kenis","year":"2013","journal-title":"Clin. Med. Insights Arthritis Musculoskelet. Disord."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/19\/3094\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T08:25:01Z","timestamp":1790238301000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/16\/19\/3094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,24]]},"references-count":9,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["diagnostics16193094"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics16193094","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,24]]}}}