{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:04:06Z","timestamp":1790759046354,"version":"4.1.0"},"reference-count":39,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background and Objective: D-dimer results differ across analytical platforms, which may affect their clinical interpretation. This study aimed to compare the analytical agreement and threshold-based classification of three routinely used D-dimer analyzers. Methods: Of 150 consecutive residual citrated plasma specimens, 81 patient specimens with valid results on the Sysmex CS-2500, Tokra Novae MTI, and VIDAS 3 analyzers were included. Agreement was assessed using the intraclass correlation coefficient, Passing\u2013Bablok regression, Bland\u2013Altman analysis, and classification concordance at the fixed (500 ng\/mL FEU) and age-adjusted thresholds. VIDAS 3 served solely as the comparator method. Results: Overall agreement was moderate to good; however, the platforms were not fully interchangeable. Sysmex CS-2500 and VIDAS 3 showed the closest agreement, with no significant constant or proportional bias, whereas Tokra Novae MTI exhibited significant proportional bias. Mixed classification across the three analyzers occurred in 21\/81 patients (25.9%) at the fixed threshold and in 18\/81 patients (22.2%) at the age-adjusted thresholds. Conclusions: Clinically relevant inter-platform differences persisted despite acceptable average agreement. Therefore, D-dimer results should not be regarded as interchangeable across analyzers, particularly near clinical decision thresholds, and platform-specific verification remains essential.<\/jats:p>","DOI":"10.3390\/diagnostics16193119","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:36:34Z","timestamp":1790346994000},"page":"3119","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Method Comparison of Three Automated D-Dimer Assays"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1052-5911","authenticated-orcid":false,"given":"Ba\u011fnu","family":"D\u00fcndar","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Medicine, Atlas University, 34408 Istanbul, 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