{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:01:11Z","timestamp":1792789271672,"version":"4.5.0"},"reference-count":71,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Oradea","award":["10347"],"award-info":[{"award-number":["10347"]}],"id":[{"id":"https:\/\/ror.org\/00wzhv093","id-type":"ROR","asserted-by":"crossref"}]},{"award":["10347"],"award-info":[{"award-number":["10347"]}],"id":[{"id":"https:\/\/ror.org\/00wzhv093","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Grover disease (GD), or transient acantholytic dermatosis, is an acquired acantholytic dermatosis that classically affects the trunk of older men, although persistent, recurrent and atypically distributed forms are increasingly recognised. We report a 29-year-old man with chronic-recurrent, intensely pruritic GD, with an estimated onset approximately six months before his first documented dermatologic assessment. The eruption predominantly involved the upper and lower limbs, with limited truncal involvement. Because of the atypical age and distribution, and because acantholysis was focal and minimal in individual specimens, the diagnosis rested on clinicopathological correlation across serial biopsies obtained during separate disease episodes, which showed spongiotic and acanthotic changes, focal parakeratosis, lichenoid and perivascular inflammation, and focal acantholysis with dyskeratosis. Direct immunofluorescence, performed during topical corticosteroid treatment, was nonspecific and did not support an autoimmune blistering disorder, although this result must be interpreted with caution. Laboratory investigations were unremarkable apart from a moderately elevated total serum immunoglobulin E (IgE) (223.2 IU\/mL), a nonspecific finding that does not establish a type 2 immune phenotype in this patient. A combined regimen of acitretin, an oral antihistamine, a topical corticosteroid and barrier-directed care was temporally associated with marked improvement, the Dermatology Life Quality Index falling from 17\/30 to 5\/30 over three months. We briefly review the histopathological patterns, differential diagnosis and management of GD and its emerging molecular and immunological context. This case illustrates the breadth of the clinical spectrum of GD, the diagnostic pitfalls of focal acantholysis and of immunofluorescence performed under treatment, and the need to consider GD in young patients with chronic-recurrent, predominantly extra-truncal eruptions.<\/jats:p>","DOI":"10.3390\/diagnostics16193176","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:17:27Z","timestamp":1790756247000},"page":"3176","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chronic-Recurrent, Limb-Predominant Grover Disease in a Young Adult: A Clinicopathological Diagnostic Challenge"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8901-8271","authenticated-orcid":false,"given":"Laura","family":"Maghiar","sequence":"first","affiliation":[{"name":"Department of Psycho-Neurosciences and Rehabilitation, Faculty of Medicine and Pharmacy, University of Oradea, Universit\u0103\u021bii Street, No. 1, 410087 Oradea, Romania"},{"name":"Faculty of Medicine and Pharmacy, University of Oradea, 1st December Square, No. 10, 410028 Oradea, Romania"},{"name":"Bihor County Emergency Clinical Hospital, 410169 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5219-5466","authenticated-orcid":false,"given":"Andreea-Adriana","family":"Neam\u021bu","sequence":"additional","affiliation":[{"name":"Department of Toxicology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timi\u0219oara, Romania"},{"name":"Research Centre for Pharmaco-Toxicological Evaluation, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timi\u0219oara, Romania"},{"name":"Department of Pathology, Clinical County Emergency Hospital of Arad, Andrenyi Karoly Street, No. 2\u20134, 310037 Arad, Romania"},{"name":"Department of Pathology, \u201cPius Br\u00eenzeu\u201d Clinical County Emergency Hospital Timi\u0219oara, Liviu Rebreanu Boulevard, No. 156, 300723 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1099-6350","authenticated-orcid":false,"given":"Teodor-Andrei","family":"Maghiar","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, University of Oradea, 1st December Square, No. 10, 410028 Oradea, Romania"},{"name":"Department of Surgery, Faculty of Medicine and Pharmacy, University of Oradea, Universit\u0103\u021bii Street, No. 1, 410087 Oradea, Romania"},{"name":"Department of Surgery, Pelican Hospital, Corneliu Coposu Street, No. 2, 410450 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4643-2151","authenticated-orcid":false,"given":"Mariana","family":"Ganea","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, University of Oradea, 1st December Square, No. 10, 410028 Oradea, Romania"},{"name":"Pharmacy Department, Faculty of Medicine and Pharmacy, University of Oradea, 1st December Square, No. 10, 410028 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1405-6836","authenticated-orcid":false,"given":"Ovidiu","family":"\u021aic\u0103","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, University of Oradea, 1st December Square, No. 10, 410028 Oradea, Romania"},{"name":"Bihor County Emergency Clinical Hospital, 410169 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruxandra Florina","family":"Bodog","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, University of Oradea, 1st December Square, No. 10, 410028 Oradea, Romania"},{"name":"Bihor County Emergency Clinical Hospital, 410169 Oradea, Romania"},{"name":"Department of Surgery, Faculty of Medicine and Pharmacy, University of Oradea, Universit\u0103\u021bii Street, No. 1, 410087 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4811-2744","authenticated-orcid":false,"given":"Teodora Maria","family":"Bodog","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, University of Oradea, 1st December Square, No. 10, 410028 Oradea, Romania"},{"name":"Bihor County Emergency Clinical Hospital, 410169 Oradea, Romania"},{"name":"Department of Surgery, Faculty of Medicine and Pharmacy, University of Oradea, Universit\u0103\u021bii Street, No. 1, 410087 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6672-1535","authenticated-orcid":false,"given":"Octavia","family":"Gligor","sequence":"additional","affiliation":[{"name":"Department of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, 1st December Square, No. 10, 410028 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5328-333X","authenticated-orcid":false,"given":"Laura Gra\u021biela","family":"Vica\u0219","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Faculty of Medicine and Pharmacy, University of Oradea, 1st December Square, No. 10, 410028 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u0103d\u0103lin Florin","family":"Ganea","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, University of Oradea, 1st December Square, No. 10, 410028 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2375-9884","authenticated-orcid":false,"given":"Csaba","family":"Nagy","sequence":"additional","affiliation":[{"name":"Doctoral School of Biomedical Sciences, University of Oradea, Universit\u0103\u021bii Street, No. 1, 410087 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilarie","family":"Brihan","sequence":"additional","affiliation":[{"name":"Department of Psycho-Neurosciences and Rehabilitation, Faculty of Medicine and Pharmacy, University of Oradea, Universit\u0103\u021bii Street, No. 1, 410087 Oradea, Romania"},{"name":"Faculty of Medicine and Pharmacy, University of Oradea, 1st December Square, No. 10, 410028 Oradea, Romania"},{"name":"Bihor County Emergency Clinical Hospital, 410169 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jaad.2026.02.074","article-title":"Acantholytic disorders: Update on pathophysiology, diagnosis, and management","volume":"95","author":"Zhou","year":"2026","journal-title":"J. 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