{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T12:48:44Z","timestamp":1768913324857,"version":"3.49.0"},"reference-count":28,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2014,6,26]],"date-time":"2014-06-26T00:00:00Z","timestamp":1403740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Gastric varices that arise secondary to the splenic vein occlusion can result in gastrointestinal hemorrhaging. Endoscopic color Doppler ultrasonography (ECDUS) was performed in 16 patients with gastric varices secondary to splenic vein occlusion.  This study retrospectively evaluated the role of ECDUS in the diagnosis of gastric varices secondary to splenic vein occlusion. Thirteen patients had co-existing pancreatic diseases: 8 with chronic pancreatitis, 4 with cancer of the pancreatic body or tail and 1 with severe acute pancreatitis. Of the remaining 3 patients, 1 had myeloproliferative disease, 1 had advanced gastric cancer, and the third had splenic vein occlusion due to an obscure cause. The endoscopic findings of gastric varices were: variceal form (F) classified as enlarged tortuous (F2) in 12 cases and large, coil-shaped (F3) in 4 cases, and positive for erosion or red color sign of the variceal surface in 4 cases and negative in 12 cases. ECDUS color flow images of gastric variceal flow clearly depicted a round fundal region at the center, with varices expanding to the curvatura ventriculi major of the gastric body in all 16 cases. The velocities of F3 type gastric varices were significantly higher than those of the F2 type. The wall thickness of varices positive for erosion or red color sign was significantly less than the negative cases. I conclude that ECDUS color flow images of gastric variceal flow depicted specific findings of gastric varices secondary to splenic vein occlusion at the round fundal region at the center, with varices expanding to the curvatura ventriculi major of the gastric body.<\/jats:p>","DOI":"10.3390\/diagnostics4030094","type":"journal-article","created":{"date-parts":[[2014,6,26]],"date-time":"2014-06-26T11:03:52Z","timestamp":1403780632000},"page":"94-103","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Endoscopic Color Doppler Ultrasonographic Evaluation of Gastric Varices Secondary to Left-Sided Portal Hypertension"],"prefix":"10.3390","volume":"4","author":[{"given":"Takahiro","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Sapporo Kosei General Hospital, Kita 3 Higashi 8, Chuo-ku,  Sapporo 060-0033, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsu","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Sapporo Kosei General Hospital, Kita 3 Higashi 8, Chuo-ku,  Sapporo 060-0033, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mutsuumi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Sapporo Kosei General Hospital, Kita 3 Higashi 8, Chuo-ku,  Sapporo 060-0033, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jouji","family":"Toyota","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Sapporo Kosei General Hospital, Kita 3 Higashi 8, Chuo-ku,  Sapporo 060-0033, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyasu","family":"Karino","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Sapporo Kosei General Hospital, Kita 3 Higashi 8, Chuo-ku,  Sapporo 060-0033, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2014,6,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S0016-5107(86)71843-9","article-title":"Endoscopic injection sclerosis in bleeding gastric varices","volume":"32","author":"Trudeau","year":"1986","journal-title":"Gastrointest. Endosc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1148\/radiographics.15.3.7624566","article-title":"Varices in portal hypertension: Evaluation with CT","volume":"15","author":"Cho","year":"1995","journal-title":"Radiographics"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s005350050268","article-title":"Evaluation of magnetic resonance angiography in detection of gastric varices","volume":"34","author":"Sato","year":"1999","journal-title":"J. Gastroenterol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1136\/gut.52.6.886","article-title":"Detection of submucosal gastric fundal varices with multi-detector row CT angiography","volume":"52","author":"Willmann","year":"2003","journal-title":"Gut"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.7326\/0003-4819-37-5-1077","article-title":"Carcinoma of the tail of the pancreas associated with bleeding gastric varices and hypersplenism","volume":"37","author":"Marks","year":"1952","journal-title":"Ann. Intern. Med."},{"key":"ref_6","first-page":"319","article-title":"Splenic vein thrombosis causing gastric varices and bleeding","volume":"58","author":"Goldstein","year":"1972","journal-title":"Am. J. Gastroenterol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/BF01655272","article-title":"Isolated splenic vein thrombosis","volume":"9","author":"Moossa","year":"1985","journal-title":"World J. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/00000658-198607000-00010","article-title":"Segmental portal hypertension","volume":"204","author":"Madsen","year":"1986","journal-title":"Ann. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1001\/archsurg.1970.01340230089024","article-title":"Isolated splenic vein occlusion","volume":"100","author":"Sutton","year":"1970","journal-title":"Arch. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1007\/BF01072140","article-title":"Splenic vein obstruction: A curable cause of variceal bleeding","volume":"21","author":"Babb","year":"1976","journal-title":"Am. J. Dig. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1148\/132.3.593","article-title":"Gastric varices secondary to splenic vein occlusion: Radiographic diagnosis and clinical significance","volume":"132","author":"Muhletaler","year":"1979","journal-title":"Radiology"},{"key":"ref_12","first-page":"17","article-title":"Hemodynamic study of occlusion of the splenic vein caused by carcinoma of the pancreas","volume":"168","author":"Ku","year":"1989","journal-title":"Surg. Gynecol. Obstet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0002-9610(00)00250-6","article-title":"The significance of sinistral portal hypertension complicating chronic pancreatitis","volume":"179","author":"Sakorafas","year":"2000","journal-title":"Am. J. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1007\/s10620-005-2674-x","article-title":"Report of 24 left-sided portal hypertension cases: A single-center prospective cohort study","volume":"50","author":"Arhan","year":"2005","journal-title":"Dig. Dis. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Paramythiotis, D., Papavramidis, T.S., Giavroglou, K., Potsi, S., Girtovitis, F., Michalopoulos, A., Papadopoulos, V.N., and Prousalidis, J. (2010). Massive variceal bleeding secondary to splenic vein thrombosis successfully treated with splenic artery embolization: A case report. J. Med. Case Rep., 4.","DOI":"10.1186\/1752-1947-4-139"},{"key":"ref_16","unstructured":"Sato, T., Kitagawa, S., Kimura, M., Ohmura, T., and Karino, Y. (2013). Gastric Varices Secondary to Splenic Vein Occlusion due to Pancreatic Diseases. Pancreatic Dis. Ther. S, 3."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0002-9610(81)90029-5","article-title":"Gastrointestinal hemorrhage from left-sided portal hypertension. An unappreciated complication of pancreatitis","volume":"141","author":"Little","year":"1981","journal-title":"Am. J. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1002\/hep.1840160607","article-title":"Prevalence, classification and natural history of gastric varices: A long-term follow-up study in 568 portal hypertensive patients","volume":"16","author":"Sarin","year":"1992","journal-title":"Hepatology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1111\/j.1872-034X.2008.00376.x","article-title":"Clinical and endoscopic features of gastric varices secondary to splenic vein occlusion","volume":"38","author":"Sato","year":"2007","journal-title":"Hepatol. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1097\/00004424-197703000-00010","article-title":"Splenic vein thrombosis in patients with a normal size spleen","volume":"12","author":"Itzchak","year":"1977","journal-title":"Investig. Radiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1097\/01.sla.0000128685.74686.1e","article-title":"The natural history of pancreatitis-induced splenic vein thrombosis","volume":"239","author":"Heider","year":"2004","journal-title":"Ann. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/j.1477-2574.2011.00375.x","article-title":"Natural history of pancreatitis-induced splenic vein thrombosis: A systematic review and meta-analysis of its incidence and rate of gastrointestinal bleeding","volume":"13","author":"Butler","year":"2011","journal-title":"HPB (Oxf.)"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1007\/BF00299178","article-title":"General rules for recording endoscopic findings of esophagogastric varices","volume":"19","author":"Idezuki","year":"1995","journal-title":"World J. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0016-5107(81)73224-3","article-title":"Prediction of variceal hemorrhage by esophageal endoscopy","volume":"27","author":"Beppu","year":"1981","journal-title":"Gastrointest. Endosc."},{"key":"ref_25","first-page":"268","article-title":"Endoscopic ultrasonography classification of gastric varices in patients with cirrhosis. Comparison with endoscopic findings","volume":"19","author":"Boustiere","year":"1993","journal-title":"J. Hapatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1055\/s-2007-1010496","article-title":"Value of endoscopic ultrasonography in the management of portal hypertension","volume":"24","author":"Caletti","year":"1992","journal-title":"Endoscopy"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1067\/mge.2000.108483","article-title":"The value of EUS in the management of portal hypertension","volume":"52","author":"Sanyal","year":"2000","journal-title":"Gastrointest. Endosc."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1572-0241.2007.01644.x","article-title":"Observation of gastric variceal flow characteristics by endoscopic ultrasonography using color Doppler","volume":"103","author":"Sato","year":"2008","journal-title":"Am. J. Gastroenterol."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/4\/3\/94\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:12:58Z","timestamp":1760217178000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/4\/3\/94"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,26]]},"references-count":28,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,9]]}},"alternative-id":["diagnostics4030094"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics4030094","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,26]]}}}