{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:43:09Z","timestamp":1760211789061,"version":"build-2065373602"},"reference-count":12,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2016,8,5]],"date-time":"2016-08-05T00:00:00Z","timestamp":1470355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Sternocostoclavicular hyperostosis (SCCH) is an ill-recognized, rarely diagnosed disease. Today, SCCH is widely considered part of the synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome. SCCH develops over years with intermittent attacks of pain, swelling, and reddening of the sternocostoclavicular region. The disease causes progressive hyperostosis, fusion of the sternocostoclavicular joints, and soft tissue ossification. SCCH is chronic, non-malignant, and occurs predominantly bilaterally in middle-aged women. The incidence of the disease is unknown. We present a case of isolated SCCH, where chest radiographs showed a clear development of bilateral disease over the course of more than a decade. Whole-body bone scintigraphy was performed and was suggestive of SCCH. The diagnosis was established as late as 14 years from the onset of symptoms. During this period, the patient underwent several inconclusive examinations, resulting in a delay of diagnosis and in prolonged and aggravated symptoms. With this case report, we want to draw attention to SCCH and the importance of early diagnosis of the disease.<\/jats:p>","DOI":"10.3390\/diagnostics6030029","type":"journal-article","created":{"date-parts":[[2016,8,5]],"date-time":"2016-08-05T10:10:24Z","timestamp":1470391824000},"page":"29","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Sternocostoclavicular Hyperostosis: An Ill-Recognized Disease"],"prefix":"10.3390","volume":"6","author":[{"given":"Bolette","family":"Roed","sequence":"first","affiliation":[{"name":"Department of Diagnostic Imaging, Nordsj\u00e6llands Hospital Hiller\u00f8d, Copenhagen University Hospital, Dyrehavevej 29, 3400 Hiller\u00f8d, Denmark"},{"name":"Department of Radiology, Rigshospitalet, Copenhagen University Hospital Copenhagen, Blegdamsvej 9, 2100 K\u00f8benhavn \u00d8, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5770-5189","authenticated-orcid":false,"given":"Tatiana","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Nordsj\u00e6llands Hospital Hiller\u00f8d, Copenhagen University Hospital, Dyrehavevej 29, 3400 Hiller\u00f8d, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f8ren","family":"Thorsen","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Infectious Diseases, Nordsj\u00e6llands Hospital Hiller\u00f8d, Copenhagen University Hospital, Dyrehavevej 29, 3400 Hiller\u00f8d, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Poulsen Bloch","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Nordsj\u00e6llands Hospital Hiller\u00f8d, Copenhagen University Hospital, Dyrehavevej 29, 3400 Hiller\u00f8d, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pia","family":"Afzelius","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Nordsj\u00e6llands Hospital Hiller\u00f8d, Copenhagen University Hospital, Dyrehavevej 29, 3400 Hiller\u00f8d, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2016,8,5]]},"reference":[{"key":"ref_1","first-page":"1519","article-title":"Sternocosto-clavicular hyperostosis: A hitherto undescribed entity","volume":"100","author":"Uehlinger","year":"1975","journal-title":"Dtsch. Med. Wochenschr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"192","DOI":"10.7326\/0003-4819-87-2-192","article-title":"Sternocostoclavicular hyperostosis: Painful swelling of the sternum, clavicles, and upper ribs","volume":"87","author":"Uehlinger","year":"1977","journal-title":"Ann. Intern. Med."},{"key":"ref_3","first-page":"187","article-title":"Acne-pustulosis-hyperostosis-osteitis syndrome. Results of a national survey 85 cases","volume":"54","author":"Chamot","year":"1987","journal-title":"Rev. Rhum. Mal. Ost\u00e9oartic."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s00393-014-1460-6","article-title":"SAPHO syndrome","volume":"73","author":"Heldmann","year":"2014","journal-title":"Z. Rheum."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.crad.2011.08.014","article-title":"SAPHO: What radiologists should know","volume":"67","author":"Depasquale","year":"2012","journal-title":"Clin. 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Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/acr.20075","article-title":"Diagnostic delay in sternocostoclavicular hyperostosis: Impact on various aspects of quality of life","volume":"62","author":"Kloot","year":"2010","journal-title":"Arthritis Care Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.semarthrit.2012.05.006","article-title":"The SAPHO Syndrome","volume":"42","author":"Nguyen","year":"2012","journal-title":"Semin. Arthritis Rheum."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/6\/3\/29\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:27:45Z","timestamp":1760210865000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/6\/3\/29"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,5]]},"references-count":12,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,9]]}},"alternative-id":["diagnostics6030029"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics6030029","relation":{},"ISSN":["2075-4418"],"issn-type":[{"type":"electronic","value":"2075-4418"}],"subject":[],"published":{"date-parts":[[2016,8,5]]}}}