{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T21:27:04Z","timestamp":1770413224390,"version":"3.49.0"},"reference-count":5,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2016,8,17]],"date-time":"2016-08-17T00:00:00Z","timestamp":1471392000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Preoperative localisation of the diseased parathyroid gland(s) in primary hyperparathyroidism (PHP) is a prerequisite for subsequent minimally invasive surgery. Recently, as alternatives to conventional sestamibi parathyroid scintigraphy, the 11C-based positron emission tomography (PET) tracers methionine and choline have shown promise for this purpose. We evaluated the feasibility of using the 18F-based PET tracer fluoroethyl-l-tyrosine (FET), as the longer half-life of 18F makes it logistically more favourable. As a proof-of-concept study, we included two patients with PHP in which dual-isotope parathyroid subtraction single photon emission computed tomography had determined the exact location of the parathyroid adenoma. A dynamic FET PET\/CT scan was performed with subsequent visual evaluation and calculation of target-to-background (TBR; parathyroid vs. thyroid). The maximum TBR in the two patients under study was achieved approximately 30 min after the injection of the tracer and was 1.5 and 1.7, respectively. This ratio was too small to allow for confident visualisation of the adenomas. FET PET\/CT seems not feasible as a preoperative imaging modality in PHP.<\/jats:p>","DOI":"10.3390\/diagnostics6030030","type":"journal-article","created":{"date-parts":[[2016,8,17]],"date-time":"2016-08-17T10:23:21Z","timestamp":1471429401000},"page":"30","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["18F-FET-PET in Primary Hyperparathyroidism: A Pilot Study"],"prefix":"10.3390","volume":"6","author":[{"given":"Martin","family":"Krakauer","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Gentofte Hospital, DK-2900 Hellerup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2706-5547","authenticated-orcid":false,"given":"Andreas","family":"Kjaer","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Nuclear Medicine &amp; PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, DK-2100 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Finn","family":"Bennedb\u00e6k","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Herlev Hospital, DK-2730 Herlev, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2016,8,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.nucmedbio.2006.01.002","article-title":"O-2-(18F)fluoroethyl-l-Tyrosine: uptake mechanisms and clinical applications","volume":"33","author":"Langen","year":"2006","journal-title":"Nucl. Med. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s11060-010-0117-9","article-title":"Correlation of l-methyl-11C-methionine (MET) uptake with l-type amino acid transporter 1 in human gliomas","volume":"99","author":"Okubo","year":"2010","journal-title":"J. Neurooncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1210\/jcem-64-1-43","article-title":"Binding of monoclonal antibody (4F2) to its cell surface antigen on dispersed adenomatous parathyroid cells raises cytosolic calcium and inhibits parathyroid hormone secretion","volume":"64","author":"Posillico","year":"1987","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/MNM.0000000000000216","article-title":"A comparison between 11C-methionine PET\/CT and MIBI SPECT\/CT for localization of parathyroid adenomas\/hyperplasia","volume":"36","author":"Hayakawa","year":"2015","journal-title":"Nucl. Med. Commun."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/RLU.0000000000000988","article-title":"A prospective comparative study of parathyroid dual-phase scintigraphy, dual-isotope subtraction scintigraphy, 4D-CT, and ultrasonography in primary hyperparathyroidism","volume":"41","author":"Krakauer","year":"2016","journal-title":"Clin. Nucl. Med."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/6\/3\/30\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:28:33Z","timestamp":1760210913000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/6\/3\/30"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,17]]},"references-count":5,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,9]]}},"alternative-id":["diagnostics6030030"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics6030030","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,17]]}}}