{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:55:55Z","timestamp":1760241355876,"version":"build-2065373602"},"reference-count":14,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2018,2,10]],"date-time":"2018-02-10T00:00:00Z","timestamp":1518220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Isolated congenital vomer agenesis is a very rare and poorly understood condition. In the context of dental work-up by cone-beam computed tomography (CBCT), the explored volume of the facial bones occasionally reveals incidental abnormalities. We report the case of a 13-year old Caucasian female who underwent CBCT for the pre-treatment evaluation of primary failure of tooth eruption affecting the permanent right upper and inferior molars. CBCT depicted a large defect of the postero-inferior part of the nasal septum without associated soft tissue abnormality and without cranio-facial malformation or cleft palate. In the absence of a history of trauma, chronic inflammatory sinonasal disease, neoplasia and drug abuse, a posterior nasal septum defect warrants the diagnosis of vomer agenesis. A discussion of this condition and of salient CBCT features is provided.<\/jats:p>","DOI":"10.3390\/diagnostics8010015","type":"journal-article","created":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T10:50:38Z","timestamp":1518432638000},"page":"15","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Congenital Vomer Agenesis: A Rare and Poorly Understood Condition Revealed by Cone Beam CT"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1983-4801","authenticated-orcid":false,"given":"David","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Imaging and Informatics Sciences, Division of Radiology, University Hospital Geneva, University of Geneva, 1211 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8140-8010","authenticated-orcid":false,"given":"Vincent","family":"Lenoir","sequence":"additional","affiliation":[{"name":"Department of Imaging and Informatics Sciences, Division of Radiology, University Hospital Geneva, University of Geneva, 1211 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sibylle","family":"Chatelain","sequence":"additional","affiliation":[{"name":"Division of Oral Surgery and Implantology, School of Dental Medicine, University of Geneva, 1211 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8203-6140","authenticated-orcid":false,"given":"Salvatore","family":"Stefanelli","sequence":"additional","affiliation":[{"name":"Department of Imaging and Informatics Sciences, Division of Radiology, University Hospital Geneva, University of Geneva, 1211 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minerva","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of Imaging and Informatics Sciences, Division of Radiology, University Hospital Geneva, University of Geneva, 1211 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,2,10]]},"reference":[{"key":"ref_1","unstructured":"Lund, V. (1997). Anatomy of the Nose and Sinuses, Butterworth Heinemann."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0169-409X(01)00172-7","article-title":"The nose and paranasal sinuses physiology and anatomy","volume":"51","author":"Jones","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S1081-1206(10)60373-0","article-title":"Pathophysiology and progression of nasal septal perforation","volume":"99","author":"Lanier","year":"2007","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1177\/000348940010900510","article-title":"Congenital defects of the vomer","volume":"109","author":"Mohri","year":"2000","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.amjoto.2004.06.016","article-title":"Congenital vomeral bone defect","volume":"26","author":"Yilmaz","year":"2005","journal-title":"Am. J. Otolaryngol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s00405-003-0619-6","article-title":"Congenital vomeral bone defect in two thalassemia trait cases","volume":"261","author":"Dogru","year":"2004","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1080\/00016480500504218","article-title":"Congenital vomeral bone defect: Report of two cases and a review of the literature","volume":"126","author":"Lee","year":"2006","journal-title":"Acta Otolaryngol."},{"key":"ref_8","first-page":"124","article-title":"The prenatal development of the human nasal and vomeral bones","volume":"14","author":"Sandikcioglu","year":"1994","journal-title":"J. Craniofac. Genet. Dev. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"182","DOI":"10.5606\/kbbihtisas.2015.37108","article-title":"Congenital vomer agenesis","volume":"25","author":"Ucar","year":"2015","journal-title":"Kulak Burun Bogaz Ihtis Derg"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1177\/014556131209100408","article-title":"Congenital os vomer agenesis: Case report and literature review","volume":"91","author":"Yorgancilar","year":"2012","journal-title":"Ear Nose Throat J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e392","DOI":"10.1016\/j.jcms.2012.02.009","article-title":"Hereditary characteristic of isolated congenital vomer aplasia","volume":"40","author":"Verim","year":"2012","journal-title":"J. Cranio-Maxillofac. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1054\/jcms.2001.0199","article-title":"Malformation of the vomer in submucous cleft palate","volume":"29","author":"Grzonka","year":"2001","journal-title":"J. Cranio-Maxillofac. Surg."},{"key":"ref_13","first-page":"1","article-title":"The formation of the nasal septum and the etiology of septal deformity. The concept of evolutionary paradox","volume":"443","author":"Takahashi","year":"1987","journal-title":"Acta Oto-Laryngol. Suppl."},{"key":"ref_14","first-page":"102","article-title":"Surgical treatment of nasal septal perforations. Our experience","volume":"26","author":"Re","year":"2006","journal-title":"Acta Otorhinolaryngol. Ital."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/8\/1\/15\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T14:54:33Z","timestamp":1760194473000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/8\/1\/15"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,10]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,3]]}},"alternative-id":["diagnostics8010015"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics8010015","relation":{},"ISSN":["2075-4418"],"issn-type":[{"type":"electronic","value":"2075-4418"}],"subject":[],"published":{"date-parts":[[2018,2,10]]}}}