{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:39:59Z","timestamp":1760240399126,"version":"build-2065373602"},"reference-count":23,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Technetium (Tc)-99m-methoxyisobutylisonitrile (MIBI) single photon-emission computed tomography\/computed tomography (SPECT\/CT) is now being used increasingly for preoperative localization of parathyroid adenomas. Tc-99m-MIBI scintigraphy in a 52-year-old man with a diagnosis of primary hyperparathyroidism revealed two focal areas with retention of radioactivity in the left lobe of the thyroid gland on the delayed phase of MIBI SPECT\/CT but no significant focal radioactive uptake on MIBI planar images. The patient subsequently underwent left partial parathyroidectomy. Histological analysis identified one lesion to be thyroid hyperplasia and the other to be parathyroid adenoma. This case demonstrates the value of MIBI SPECT\/CT for localization of a parathyroid lesion when compared with planar images and that false-positive findings can lead to misdiagnosis in a patient with coexisting thyroid disease. An appropriate diagnostic work-up that includes Tc-99m MIBI SPECT\/CT in addition to ultrasonography is helpful for an accurate diagnosis in patients with concomitant thyroid disease.<\/jats:p>","DOI":"10.3390\/diagnostics9020057","type":"journal-article","created":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T02:08:40Z","timestamp":1559527720000},"page":"57","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Detecting Synchronous Parathyroid Adenoma and False-Positive Findings on Technetium-99m MIBI Single Photon-Emission Computed Tomography\/Computed Tomography"],"prefix":"10.3390","volume":"9","author":[{"given":"Ji","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Jeju National University Hospital, Jeju National University School of Medicine, Jeju-si 63241, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3891-8848","authenticated-orcid":false,"given":"Hee-Sung","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Jeju National University Hospital, Jeju National University School of Medicine, Jeju-si 63241, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Jeju National University Hospital, Jeju National University School of Medicine, Jeju-si 63241, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang","family":"Hyun","sequence":"additional","affiliation":[{"name":"Department of Pathology, Jeju National University Hospital, Jeju National University School of Medicine, Jeju-si 63241, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Jeju National University Hospital, Jeju National University School of Medicine, Jeju-si 63241, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joon-Hyouk","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Jeju National University Hospital, Jeju National University School of Medicine, Jeju-si 63241, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seokjae","family":"Lee","sequence":"additional","affiliation":[{"name":"Jeju National University College of Medicine and Graduate School of Medicine, Jeju-si 63241, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1007\/s00259-007-0388-3","article-title":"Scintigraphic techniques in primary hyperparathyroidism: From pre-operative localisation to intra-operative imaging","volume":"34","author":"Rubello","year":"2007","journal-title":"Eur. 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