{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T14:09:03Z","timestamp":1787580543247,"version":"build-2736575974"},"reference-count":16,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T00:00:00Z","timestamp":1571356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"This study was funded by grants of Taipei Tzu Chi Hospital (TCRD-TPE-108-5).","award":["TCRD-TPE-108-5"],"award-info":[{"award-number":["TCRD-TPE-108-5"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>A spontaneous rupture of the spleen is a rare but critical diagnosis of an acute abdomen, which may accompany unspecific symptoms mimicking acute pancreatitis, rupture of aortic aneurism, or acute coronary syndrome, delaying diagnosis and treatment. In patients that have experienced a severe spleen rupture, hypovolemic shock may cause catastrophic clinical outcomes. Therefore, early diagnosis is very important in order for physicians to declare the etiology for prevention and timely correction of the shock status. Several causes of spontaneous splenic rupture have been reported, including infection, vasculitis, pancreatitis, or hematological malignancies. Acute lymphoblastic leukemia (ALL) remains a rare but important cause of non-traumatic splenic rupture that physicians are required to assess for. Here, we describe a case presenting an acute abdomen due to spontaneous spleen rupture as the first manifestation. The purpose of this case report was to highlight the importance of considering spontaneous ruptures of the spleen as a rare but critical differential diagnosis of an acute abdomen, especially in patients with acute lymphoblastic leukemia.<\/jats:p>","DOI":"10.3390\/diagnostics9040152","type":"journal-article","created":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T04:12:59Z","timestamp":1571371979000},"page":"152","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Spontaneous Splenic Rupture as a Rare Initial Presentation in an Acute Lymphoblastic Leukemia Patient"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8773-1847","authenticated-orcid":false,"given":"Meng-Yu","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei 231, Taiwan"},{"name":"Department of Emergency Medicine, School of Medicine, Tzu Chi University, Hualien 970, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woei-Yau","family":"Kao","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taipei 231, Taiwan"},{"name":"Department of Medicine, School of Medicine, Tzu Chi University, Hualien 970, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Yi","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Taipei Tzu Chi Hospital, the Buddhist Tzu Chi Medical Foundation, New Taipei 231 Taiwan"},{"name":"Department of Medical Imaging, School of Medicine, Tzu Chi University, Hualien 970, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8473-3591","authenticated-orcid":false,"given":"Giou-Teng","family":"Yiang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei 231, Taiwan"},{"name":"Department of Emergency Medicine, School of Medicine, Tzu Chi University, Hualien 970, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Ting","family":"Liao","sequence":"additional","affiliation":[{"name":"Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan"},{"name":"Chinese Medicine Department, Show Chwan Memorial Hospital, Changhua 500, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Sheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei 231, Taiwan"},{"name":"Department of Emergency Medicine, School of Medicine, Tzu Chi University, Hualien 970, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"733.e735","DOI":"10.1016\/j.ajem.2007.11.003","article-title":"Spontaneous rupture of the spleen: A rare but important differential of an acute abdomen","volume":"26","author":"Rhee","year":"2008","journal-title":"Am. J. Emerg. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1191\/096120301701548535","article-title":"Spontaneous rupture of the spleen: An unusual complication of systemic lupus erythematosus","volume":"10","author":"Karassa","year":"2001","journal-title":"Lupus"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1159\/000327215","article-title":"Spontaneous splenic rupture: A rare complication of acute pancreatitis in a patient with Crohn\u2019s disease","volume":"5","author":"Mujtaba","year":"2011","journal-title":"Case Rep. Gastroenterol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/S0022-3468(99)90512-2","article-title":"Spontaneous rupture of splenic hamartoma: A case report","volume":"34","author":"Yoshizawa","year":"1999","journal-title":"J. Pediatric Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ijscr.2011.08.012","article-title":"Spontaneous splenic rupture resulted from infectious mononucleosis","volume":"3","author":"Won","year":"2012","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/jso.2930410312","article-title":"Splenic rupture in leukemia","volume":"41","author":"Canady","year":"1989","journal-title":"J. Surg. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Shiber, J., Fontane, E., and Prisk, D. (2016). ATraumatic Splenic Rupture: Dreaded Complication of Splenomegaly. Trop. Med. Surg., 2.","DOI":"10.4172\/2329-9088.1000162"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1002\/bjs.6737","article-title":"Systematic review of atraumatic splenic rupture","volume":"96","author":"Renzulli","year":"2009","journal-title":"Br. J. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s002770050245","article-title":"Pathologic rupture of the spleen in hematologic malignancies: Two additional cases","volume":"73","author":"Giagounidis","year":"1996","journal-title":"Ann. Hematol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/MAJ.0000000000000374","article-title":"Malignant cause of abdominal pain in leukemia: Spontaneous splenic rupture","volume":"349","author":"Modi","year":"2015","journal-title":"Am. J. Med. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1002\/1097-0142(19811215)48:12<2729::AID-CNCR2820481229>3.0.CO;2-K","article-title":"Splenic rupture in patients with hematologic malignancies","volume":"48","author":"Bauer","year":"1981","journal-title":"Cancer"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Jafferbhoy, S., Chantry, A., Atkey, N., Turner, D., and Wyld, L. (2011). Spontaneous splenic rupture: An unusual presentation of CML. Bmj Case Rep., 2011.","DOI":"10.1136\/bcr.02.2011.3879"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/s13238-010-0016-z","article-title":"Molecular and cellular bases of chronic myeloid leukemia","volume":"1","author":"Chen","year":"2010","journal-title":"Protein Cell"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Wu, M.-Y., Lin, C.-H., Hou, Y.-T., Lin, P.-C., Yiang, G.-T., Tien, Y.-C., and Yeh, H.-C. (2019). Syncope as Initial Presentation in an Undifferentiated Type Acute Myeloid Leukemia Patient with Acute Intracranial Hemorrhage. Brain Sci., 9.","DOI":"10.3390\/brainsci9080207"},{"key":"ref_15","first-page":"201","article-title":"Spontaneous Splenic Rupture in Acute Lymphoblastic Leukemia: Successful Nonoperative Management","volume":"134","author":"SOORYA","year":"1980","journal-title":"Jama Pediatrics"},{"key":"ref_16","first-page":"760","article-title":"Pathologic rupture of the spleen as the initial manifestation in acute lymphoblastic leukemia","volume":"83","author":"Bernat","year":"1998","journal-title":"Haematologica"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/9\/4\/152\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:27:26Z","timestamp":1760189246000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/9\/4\/152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,18]]},"references-count":16,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,12]]}},"alternative-id":["diagnostics9040152"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics9040152","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,18]]}}}