{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:33:00Z","timestamp":1782513180585,"version":"3.54.5"},"reference-count":38,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T00:00:00Z","timestamp":1573776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Scientific and Technological Research Council of TurkEY","award":["213S133"],"award-info":[{"award-number":["213S133"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>The objective of this study was to investigate the development of a surface plasmon resonance (SPR) sensor platform equipped with multiple channels for the simultaneous determination of methicillin-resistant S. aureus (MRSA), methicillin-susceptible S. aureus (MSSA) and vancomycin-resistant Enterococcus (VRE), and vancomycin-susceptible Enterococcus (VSE). Drug resistance of S. aureus strains against cefoxitin and Enterococcus strains against vancomycin were investigated both using the minimum inhibitory concentration method (MIC) assay and the SPR system equipped with single and multiple channels. The MIC values of MRSA and MSSA ranged from 32 \u00b5g\/mL to &gt;128 \u00b5g\/mL and from 1 \u00b5g\/mL to 4 \u00b5g\/mL, respectively. The MIC values of VRE and VSE were between 64 to &gt;128 \u00b5g\/mL and 2\u20134 \u00b5g\/mL, respectively. With the multiple-channel system, the angle shifts of MRSA, MSSA, VRE and VSE were found to be \u22120.030\u00b0 and \u22120.260\u00b0, \u22120.010\u00b0 and \u22120.090\u00b0 respectively. The antibiotic-resistant and susceptible strains were distinguished within 3 h for S. aureus strains and within 6 h for Enterococcus strains.<\/jats:p>","DOI":"10.3390\/diagnostics9040191","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T11:25:56Z","timestamp":1573817156000},"page":"191","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Antimicrobial Susceptibility Test for the Determination of Resistant and Susceptible S. aureus and Enterococcus spp. Using a Multi-Channel Surface Plasmon Resonance Device"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4207-6797","authenticated-orcid":false,"given":"Gulsum","family":"Ucak Ozkaya","sequence":"first","affiliation":[{"name":"Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Yildiz Technical University, Istanbul 34210, Turkey"},{"name":"Department of Food Engineering, Faculty of Engineering and Architecture, Bitlis Eren University, Bitlis 13000, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed Zeki","family":"Durak","sequence":"additional","affiliation":[{"name":"Department of Food Engineering, Faculty of Chemical and Metallurgical Engineering, Yildiz Technical University, Istanbul 34210, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isin","family":"Akyar","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, School of Medicine, Acibadem University, Istanbul 34752, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7061-2246","authenticated-orcid":false,"given":"Onur","family":"Karatuna","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, School of Medicine, Acibadem University, Istanbul 34752, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,11,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.mpmed.2013.08.010","article-title":"Nosocomial infections and infection control","volume":"41","author":"Breathnach","year":"2013","journal-title":"Medicine"},{"key":"ref_2","unstructured":"WHO (2019, April 05). 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