{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T23:22:22Z","timestamp":1785280942424,"version":"3.55.0"},"reference-count":26,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T00:00:00Z","timestamp":1576022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Acute cardiac events are a significant contributor to mortality in systemic sclerosis (SSc). However, echocardiographic evaluation may be deceptively normal during an acute presentation. We hypothesized that in diffuse SSc patients presenting with acute cardiac events and a normal echocardiogram, cardiovascular magnetic resonance (CMR) would have incremental diagnostic\/prognostic value. Methods. 50 consecutive diffuse SSc patients with normal echocardiograms were evaluated using a 1.5T system. A total of 27 (63%) had experienced an acute cardiac event three to tendays before CMR evaluation (rhythm disturbances, angina pectoris, shortness of breath). Left\/right ventricular (LV\/RV) volumes and ejection fractions (EF), as well as LV mass, the T2-signal ratio, early\/late gadolinium enhancement (EGE\/LGE), native\/post-contrast T1-mapping, T2-mapping and extracellular volume fraction (ECV) were compared between the event and no-event groups. Results: No differences were identified in LV\/RV volumes\/EF\/mass. In logistic regression analyses, independent predictors of belonging to the event group were EGE (odds ratio (95% CI): 1.55 (1.06\u20132.26), p = 0.024), LGE (1.81 (1.23\u20132.67), p = 0.003), T2 mapping (1.20 (1.06\u20131.36), p = 0.004) and native\/post-contrast T1 mapping (1.17 (1.04\u20131.32), p = 0.007 and 0.86 (0.75\u20130.98), p = 0.025). At a median follow-up of ~1.2 years, 42% vs. 11% of the event\/no-event group respectively reached a combined endpoint of event occurrence\/recurrence or cardiovascular mortality. Of the independent predictors resulting from logistic regression analyses, only LGE (hazard ratio (95% CI): 1.20 (1.11\u20131.30), p &lt; 0.001), T2-mapping (1.07 (1.01\u20131.14), p = 0.025) and native T1-mapping (1.08 (1.01\u20131.15), p = 0.017) independently predicted the combined endpoint. Conclusions: A normal echocardiogram does not preclude myocardial lesions in diffuse SSc patients, which can be detected by CMR especially in symptomatic patients.<\/jats:p>","DOI":"10.3390\/diagnostics9040220","type":"journal-article","created":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T03:20:16Z","timestamp":1576120816000},"page":"220","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Cardiovascular Magnetic Resonance Identifies High-Risk Systemic Sclerosis Patients with Normal Echocardiograms and Provides Incremental Prognostic Value"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8192-6670","authenticated-orcid":false,"given":"George","family":"Markousis-Mavrogenis","sequence":"first","affiliation":[{"name":"Department of Cardiology, Onassis Cardiac Surgery Center, 17674 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasiliki-Kalliopi","family":"Bournia","sequence":"additional","affiliation":[{"name":"Joint Rheumatology Programme, National and Kapodistrian University of Athens Medical School, 15772 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stylianos","family":"Panopoulos","sequence":"additional","affiliation":[{"name":"Joint Rheumatology Programme, National and Kapodistrian University of Athens Medical School, 15772 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loukia","family":"Koutsogeorgopoulou","sequence":"additional","affiliation":[{"name":"Pathophysiology Department, Laikon Hospital, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Kanoupakis","sequence":"additional","affiliation":[{"name":"MRI Unit, Mediterraneo Hospital, 16675 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Apostolou","sequence":"additional","affiliation":[{"name":"MRI Unit, Mediterraneo Hospital, 16675 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gikas","family":"Katsifis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Naval Hospital, 11521 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michail","family":"Polychroniadis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Evangelismos Hospital, 10676 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0364-1642","authenticated-orcid":false,"given":"Theodoros","family":"Dimitroulas","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genovefa","family":"Kolovou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Onassis Cardiac Surgery Center, 17674 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George D.","family":"Kitas","sequence":"additional","affiliation":[{"name":"Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester M139PL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie I.","family":"Mavrogeni","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Onassis Cardiac Surgery Center, 17674 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros P.","family":"Sfikakis","sequence":"additional","affiliation":[{"name":"Joint Rheumatology Programme, National and Kapodistrian University of Athens Medical School, 15772 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e267","DOI":"10.1016\/j.lpm.2014.08.001","article-title":"Pathophysiology of systemic sclerosis: State of the art in 2014","volume":"43","author":"Dumoitier","year":"2014","journal-title":"Presse Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1007\/s10067-014-2666-3","article-title":"Heart involvement in systemic sclerosis: A combined echocardiographic and scintigraphic study","volume":"33","author":"Papagoras","year":"2014","journal-title":"Clin. 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Imaging, 20.","DOI":"10.1093\/ehjci\/jez117"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/9\/4\/220\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:41:22Z","timestamp":1760190082000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/9\/4\/220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,11]]},"references-count":26,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,12]]}},"alternative-id":["diagnostics9040220"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics9040220","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,11]]}}}