{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T17:48:08Z","timestamp":1769881688292,"version":"3.49.0"},"reference-count":56,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T00:00:00Z","timestamp":1657238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>In recent years, it has been shown that gastrointestinal microflora has a substantial impact on the development of a large number of chronic diseases. The imbalance in the number or type of microbes in the gastrointestinal tract can lead to diseases and conditions, including autism spectrum disorder, celiac disease, Crohn\u2019s disease, diabetes, and small bowel cancers. This can occur as a result of genetics, alcohol, tobacco, chemotherapeutics, cytostatics, as well as antibiotic overuse. Due to this, essential taxa can be lost, and the host\u2019s metabolism can be severely affected. A less known condition called small intestine bacterial overgrowth (SIBO) can be seen in patients who suffer from hypochlorhydria and small intestine cancers. It is characterized as a state in which the bacterial population in the small intestine exceeds 105\u2013106 organisms\/mL. The latest examination methods such as double-balloon enteroscopy and wireless capsule endoscopy have the potential to increase the accuracy and precision of diagnosis and provide better patient care. This review paper aims to summarize the effect of the gastrointestinal environment on chronic disease severity and the development of cancers.<\/jats:p>","DOI":"10.3390\/diseases10030045","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T11:37:08Z","timestamp":1657280228000},"page":"45","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Gastrointestinal Tract Microbiome Effect and Role in Disease Development"],"prefix":"10.3390","volume":"10","author":[{"given":"Neira","family":"Crn\u010devi\u0107","sequence":"first","affiliation":[{"name":"Department of Genetics and Bioengineering, International Burch University, Francuske revolucije bb, Ilid\u017ea, 71210 Sarajevo, Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirsada","family":"Huki\u0107","sequence":"additional","affiliation":[{"name":"Academy of Sciences and Arts of Bosnia and Herzegovina, Center for Disease Control and Geohealth Studies, Bistrik 7, 71000 Sarajevo, Bosnia and Herzegovina"},{"name":"Institute for Biomedical Diagnostics and Research Nalaz, \u010cekalu\u0161a 69, 71000 Sarajevo, Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Deumi\u0107","sequence":"additional","affiliation":[{"name":"Department of Genetics and Bioengineering, International Burch University, Francuske revolucije bb, Ilid\u017ea, 71210 Sarajevo, Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0601-2355","authenticated-orcid":false,"given":"Amir","family":"Selimagi\u0107","sequence":"additional","affiliation":[{"name":"Department of Gastroenterohepatology, General Hospital \u201cPrim. dr. 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