{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T12:41:46Z","timestamp":1778503306415,"version":"3.51.4"},"reference-count":36,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>Background: The aim of this single-center combined prospective\/retrospective cohort study was to analyze Gadolinium (Gd)-enhanced MRA (magnetic resonance angiography) and MRV (MR venography) for the diagnosis of pulmonary artery embolism and deep venous thrombosis. The gold standard methods result in major exposure to radiation and a high amount of nephrotoxic iodinated contrast media. This is the first larger contrast-enhanced MR imaging study of acute and chronic venous thromboembolic disease of various stages. Methods: We prospectively examined 88 patients presenting clinical signs of deep vein thrombosis and\/or pulmonary artery embolism. A single-session, one-stop shop Gd-enhanced MRA\/MRV at 1.5 Tesla, using gradient echo sequences with very short repetition and echo times as well as low flip angles with subtraction and three-dimensional reconstruction, was performed. A diagnosis was made with the consensus of two experienced radiologists. Results: We observed excellent MRA image quality in 87% and even higher diagnostic image quality of MRV in 90% of our examinations. Pulmonary artery embolism occurred with deep vein thrombosis in 22%. Conclusions: Gd-enhanced MRA\/MRV provided excellent image quality for the diagnosis of venous thromboembolic disease in the majority of cases. It may be particularly useful to plan and follow-up filter implantation and retrieval in the inferior caval vein.<\/jats:p>","DOI":"10.3390\/diseases10040122","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T03:38:38Z","timestamp":1670211518000},"page":"122","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Gadofosveset-Trinatrium-Enhanced MR Angiography and MR Venography in the Diagnosis of Venous Thromboembolic Disease: A Single-Center Cohort Study"],"prefix":"10.3390","volume":"10","author":[{"given":"Manuela A.","family":"Aschauer","sequence":"first","affiliation":[{"name":"Department of Radiology, Medical University of Graz, 8036 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2971-8422","authenticated-orcid":false,"given":"Ingeborg M.","family":"Keeling","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Medical University of Graz, 8036 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen V.","family":"Salvan-Schaschl","sequence":"additional","affiliation":[{"name":"Department of Radiology, Medical University of Graz, 8036 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor","family":"Knez","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Medical University of Graz, 8036 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Binder","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Medical University of Graz, 8036 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard B.","family":"Raggam","sequence":"additional","affiliation":[{"name":"Department of Angiology, Medical University of Graz, 8036 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ameli E.","family":"Trantina-Yates","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Medical University of Graz, 8036 Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1161\/ATVBAHA.113.302931","article-title":"Fibrin-targeted magnetic resonance imaging allows in vivo quantification of thrombus fibrin content and identifies thrombi amenable for thrombolysis","volume":"34","author":"Andia","year":"2014","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1161\/CIR.0b013e318214914f","article-title":"Management of massive and submassive pulmonary embolism, iliofemoral deep vein thrombosis, and chronic thromboembolic pulmonary hypertension: A scientific statement from the American Heart Association","volume":"123","author":"Jaff","year":"2011","journal-title":"Circulation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1259\/bjr\/26121475","article-title":"Magnetic resonance imaging findings in acute pulmonary embolism","volume":"84","author":"Hochegger","year":"2011","journal-title":"Br. J. Radiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1177\/000331970505600410","article-title":"Three-dimensional gadolinium-enhanced magnetic resonance angiography used as a \u201cone-stop shop\u201d imaging procedure for venous thromboembolism: A pilot study","volume":"56","author":"Obernosterer","year":"2005","journal-title":"Angiology"},{"key":"ref_5","first-page":"2100412","article-title":"Randomised controlled trial of a prognostic assessment and management pathway to reduce the length of hospital stay in normotensive patients with acute pulmonary embolism","volume":"59","author":"Otero","year":"2021","journal-title":"Eur. Respir. J."},{"key":"ref_6","unstructured":"Gurney, J.W. (2006). Pulmonary Emboli. Diagnostic Imaging Chest, Part II, Section 4: Pulmonary Vasculature, Amyrsys. [1st ed.]."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1161\/STROKEAHA.114.005539","article-title":"Diagnostic yield of pelvic magnetic resonance venography in patients with cryptogenic stroke and patent foramen ovale","volume":"45","author":"Liberman","year":"2014","journal-title":"Stroke"},{"key":"ref_8","first-page":"1","article-title":"Bein- und Beckenvenenthrombose (TVT)","volume":"78","author":"Gerlach","year":"2010","journal-title":"Vasa Suppl."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1148\/radiology.211.1.r99ap1859","article-title":"Stepping-table gadolinium-enhanced digital subtraction MR angiography of the aorta and lower extremity arteries: Preliminary experience","volume":"211","author":"Meany","year":"1992","journal-title":"Radiology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1007\/s00330-010-1918-0","article-title":"Combined magnetic resonance imaging of deep venous thrombosis and pulmonary arteries after a single injection of a blood pool contrast agent","volume":"21","author":"Hansch","year":"2011","journal-title":"Eur. Radiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"52","DOI":"10.4329\/wjr.v10.i6.52","article-title":"Magnetic resonance angiograpy for the primary diagnosis of pulmonary embolism: A review from the international workshop for pulmonary functional imaging","volume":"10","author":"Tsuchiya","year":"2018","journal-title":"World J. Radiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1093\/eurheartj\/ehz405","article-title":"2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS)","volume":"41","author":"Konstantinides","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/RLI.0000000000000307","article-title":"Gadobutrol in renally impaired patients\u2014Results of the GRIP study","volume":"52","author":"Michaely","year":"2017","journal-title":"Investig. Radiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"434","DOI":"10.7326\/0003-4819-152-7-201004060-00008","article-title":"Gadolinium-enhanced magnetic resonance angiography for pulmonary embolism: A multicenter prospective study (PIOPED III)","volume":"152","author":"Stein","year":"2010","journal-title":"Ann. Intern. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s11596-020-2164-6","article-title":"Combined MR imaging for pulmonary embolism and deep venous thrombosis by contrast-enhanced MR volume interpolated body examination","volume":"40","author":"Fu","year":"2020","journal-title":"Curr. Med. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Schneider, G., Prince, M.R., Meaney, J.F.M., and Ho, V.B. (2005). MR Venography. Magnetic Resonance Angiography, Springer.","DOI":"10.1007\/b138651"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/BF02733959","article-title":"Use of Wallstent in the venous system including hemodialysis-related stenoses","volume":"15","author":"Zollikofer","year":"1992","journal-title":"Cardiovasc. Interv. Radiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1148\/radiol.2352040089","article-title":"Peripheral arterial disease: Comparison of color duplex US and contrast-enhanced MR angiography for diagnosis","volume":"235","author":"Leiner","year":"2005","journal-title":"Radiology"},{"key":"ref_19","first-page":"2276","article-title":"Guidelines on the diagnosis and management of acute pulmonary embolism. The task force for diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC)","volume":"29","author":"Torbicki","year":"2008","journal-title":"Eur. Heart J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s10554-011-9820-7","article-title":"Factors in the technical quality of gadolinium enhanced magnetic resonance angiography for pulmonary embolism in PIOPED III","volume":"28","author":"Sostman","year":"2012","journal-title":"Int. J. Cardiovasc. Imag."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s10554-011-9821-6","article-title":"Signal quality of single dose gadobenate dimeglumine pulmonary MRA examinations exceeds quality of MRA performed with double dose gadopentetate dimeglumine","volume":"28","author":"Woodard","year":"2012","journal-title":"Int. J. Cardiovasc. Imag."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ejrad.2009.04.052","article-title":"Gadofosveset trisodium-enhanced magnetic resonance angiography of the left atrium\u2014A feasibility study","volume":"75","author":"Wagner","year":"2010","journal-title":"Eur. J. Radiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/VHRM.S1968","article-title":"Gadofosveset-enhanced magnetic resonance angiography","volume":"4","author":"Goyen","year":"2008","journal-title":"Vasc. Health Risk Manag."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.ejrad.2007.03.018","article-title":"A multi-center, comparative, phase 3 study to determine the efficacy of gadofosveset-enhanced magnetic resonance angiography for evaluation of renal artery disease","volume":"65","author":"McGregor","year":"2008","journal-title":"Eur. J. Radiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"476","DOI":"10.2214\/AJR.09.3868","article-title":"Gadobenate Dimenglumine and Gadofosveset Trisodium for MR Angiography of the renal arteries: Multicenter intraindividual crossover comparison","volume":"195","author":"Schneider","year":"2010","journal-title":"AJR Am. J. Roentgenol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1055\/s-2006-927371","article-title":"Diagnostic performance of contrast-enhanced angiography of the aortoiliac arteries with the blood pool agent Vasovist: Initial results in comparison to arterial DAS","volume":"179","author":"Vogt","year":"2007","journal-title":"Rofo"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.mric.2009.01.001","article-title":"Pulmonary MR angiography techniques and applications","volume":"17","author":"Hecht","year":"2009","journal-title":"Magn. Reson. Imaging Clin. N. Am."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s00330-011-2290-4","article-title":"Diagnostic performance of state-of-the-art imaging techniques for morphology assessment of vascular abnormalities in patients with chronic thromboembolic pulmonary hypertension (CTEPH)","volume":"22","author":"Ley","year":"2011","journal-title":"Eur. Radiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1007\/s00330-002-1615-8","article-title":"Nontraumatic vascular emergencies: Imaging and intervention in acute venous occlusion","volume":"12","author":"Haage","year":"2002","journal-title":"Eur. Radiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1002\/jmri.22046","article-title":"Visualization of deep veins and detection of deep vein thrombosis (DVT) with balancec turbo field echo (b-TFE) and contrast-enhanced T1 fast field echo (CE-FFE) using a blood pool agent (BPA)","volume":"31","author":"Enden","year":"2010","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"D37","DOI":"10.1007\/s10406-005-0144-3","article-title":"MDCT for the diagnosis of acute pulmonary embolism","volume":"15","author":"Prokop","year":"2005","journal-title":"Eur. Radiol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Kauczor, H.U. (2009). MR Angiography of the Pulmonary Vasculature. MRI of the Lung, Springer.","DOI":"10.1002\/9780470745007.ch9"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1002\/mrm.10607","article-title":"Value of a blood pool contrast agent in MR venography of the lower extremities and pelvis: Preliminary results in 12 patients","volume":"50","author":"Aschauer","year":"2003","journal-title":"Magn. Reson. Med."},{"key":"ref_34","first-page":"587","article-title":"CardioPulse: Interventional treatment of venous thromboembolism: A review and update of treatments in 2014","volume":"36","author":"Kucher","year":"2015","journal-title":"Eur. Heart J."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1148\/radiol.2263021476","article-title":"MR Venography: Unsung and Underutilized","volume":"226","author":"Prince","year":"2003","journal-title":"Radiology"},{"key":"ref_36","unstructured":"Yuan, C., and Li, D. (2022, January 23\u201326). Evaluation of aortic stent endoleaks using ferumoxytol enhanced MR angiography. Proceedings of the 34th Annual International Conference of SMRA, Los Angeles, CA, USA. Available online: https:\/\/society4mra.org\/index.php\/smra-2022-annual-meeting."}],"container-title":["Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-9721\/10\/4\/122\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:34:05Z","timestamp":1760146445000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-9721\/10\/4\/122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,5]]},"references-count":36,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["diseases10040122"],"URL":"https:\/\/doi.org\/10.3390\/diseases10040122","relation":{},"ISSN":["2079-9721"],"issn-type":[{"value":"2079-9721","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,5]]}}}