{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T02:02:26Z","timestamp":1785549746393,"version":"3.56.0"},"reference-count":56,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,22]],"date-time":"2023-01-22T00:00:00Z","timestamp":1674345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>Background: Hashimoto\u2019s thyroiditis (HT) is a chronic autoimmune thyroiditis that causes systemic inflammation in the body, leading to hypothyroidism and an enlargement of the thyroid gland. Objectives: This study aims to reveal whether there is a relationship between Hashimoto\u2019s thyroiditis and the platelet-count-to-lymphocyte-count ratio (PLR), which is used as a new inflammatory marker. Methods: In this retrospective study, we compared the PLR of the euthyroid HT group and the hypothyroid-thyrotoxic HT group to the controls. We also evaluated the values of thyroid-stimulating hormone (TSH), free T4 (fT4), C-reactive protein (CRP), aspartate transaminase (AST), alanine transaminase (ALT), white blood cell count, lymphocyte count, hemoglobin, hematocrit, and platelet count in each group. Results: The PLR of the subjects with Hashimoto\u2019s thyroiditis was found to be significantly different from the control group (p &lt; 0.001), with the rankings as follows: hypothyroid-thyrotoxic HT 177% (72\u2013417) &gt; euthyroid HT 137% (69\u2013272) &gt; control group 103% (44\u2013243). In addition to the increased PLR values, an increase in CRP values was also observed, revealing a strong positive correlation between the PLR and CRP in the HT patients. Conclusion: In this study, we found out that the PLR was higher in the hypothyroid-thyrotoxic HT and euthyroid HT patients than in a healthy control group.<\/jats:p>","DOI":"10.3390\/diseases11010015","type":"journal-article","created":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T02:01:02Z","timestamp":1674439262000},"page":"15","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["A Novel Inflammatory Marker for the Diagnosis of Hashimoto\u2019s Thyroiditis: Platelet-Count-to-Lymphocyte-Count Ratio"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8017-469X","authenticated-orcid":false,"given":"Eray","family":"Erge","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Abant Izzet Baysal University Hospital, 14200 Bolu, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cagri","family":"Kiziltunc","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Abant Izzet Baysal University Hospital, 14200 Bolu, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumeyye Buse","family":"Balci","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Abant Izzet Baysal University Hospital, 14200 Bolu, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burcin Meryem","family":"Atak Tel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Abant Izzet Baysal University Hospital, 14200 Bolu, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2811-0052","authenticated-orcid":false,"given":"Satilmis","family":"Bilgin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Abant Izzet Baysal University Hospital, 14200 Bolu, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuba Taslamacioglu","family":"Duman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Abant Izzet Baysal University Hospital, 14200 Bolu, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7306-5233","authenticated-orcid":false,"given":"Gulali","family":"Aktas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Abant Izzet Baysal University Hospital, 14200 Bolu, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1055\/s-2004-820913","article-title":"Factors Associated with Bone Metabolism in Acromegalic Patients: Hypogonadism and Female Gender","volume":"112","year":"2004","journal-title":"Exp. 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