{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:18:58Z","timestamp":1792145938253,"version":"4.4.0"},"reference-count":266,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T00:00:00Z","timestamp":1687651200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Institution of Eminence Incentive Grant Scheme"},{"name":"Institute of Medical Sciences intramural grant, Banaras Hindu University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>Wnt\/\u03b2-catenin (W\u03b2C) signaling pathway is an important signaling pathway for the maintenance of cellular homeostasis from the embryonic developmental stages to adulthood. The canonical pathway of W\u03b2C signaling is essential for neurogenesis, cell proliferation, and neurogenesis, whereas the noncanonical pathway (WNT\/Ca2+ and WNT\/PCP) is responsible for cell polarity, calcium maintenance, and cell migration. Abnormal regulation of W\u03b2C signaling is involved in the pathogenesis of several neurodegenerative diseases such as Alzheimer\u2019s disease (AD), Parkinson\u2019s disease (PD), Huntington\u2019s disease (HD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and spinal muscular atrophy (SMA). Hence, the alteration of W\u03b2C signaling is considered a potential therapeutic target for the treatment of neurodegenerative disease. In the present review, we have used the bibliographical information from PubMed, Google Scholar, and Scopus to address the current prospects of W\u03b2C signaling role in the abovementioned neurodegenerative diseases.<\/jats:p>","DOI":"10.3390\/diseases11030089","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T05:39:13Z","timestamp":1687757953000},"page":"89","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":186,"title":["WNT-\u03b2 Catenin Signaling as a Potential Therapeutic Target for Neurodegenerative Diseases: Current Status and Future Perspective"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2067-1410","authenticated-orcid":false,"given":"Kakarla","family":"Ramakrishna","sequence":"first","affiliation":[{"name":"KL College of Pharmacy, Koneru Lakshmaiah Education Foundation Deemed to be University (KLU), Green Fields, Vaddeswaram, Guntur 522502, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6077-1099","authenticated-orcid":false,"given":"Lakshmi Vineela","family":"Nalla","sequence":"additional","affiliation":[{"name":"KL College of Pharmacy, Koneru Lakshmaiah Education Foundation Deemed to be University (KLU), Green Fields, Vaddeswaram, Guntur 522502, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dumala","family":"Naresh","sequence":"additional","affiliation":[{"name":"KL College of Pharmacy, Koneru Lakshmaiah Education Foundation Deemed to be University (KLU), Green Fields, Vaddeswaram, Guntur 522502, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4657-0481","authenticated-orcid":false,"given":"Kojja","family":"Venkateswarlu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology, IIT BHU, Varanasi 221005, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matte Kasi","family":"Viswanadh","sequence":"additional","affiliation":[{"name":"KL College of Pharmacy, Koneru Lakshmaiah Education Foundation Deemed to be University (KLU), Green Fields, Vaddeswaram, Guntur 522502, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buchi N.","family":"Nalluri","sequence":"additional","affiliation":[{"name":"KL College of Pharmacy, Koneru Lakshmaiah Education Foundation Deemed to be University (KLU), Green Fields, Vaddeswaram, Guntur 522502, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guntupalli","family":"Chakravarthy","sequence":"additional","affiliation":[{"name":"KL College of Pharmacy, Koneru Lakshmaiah Education Foundation Deemed to be University (KLU), Green Fields, Vaddeswaram, Guntur 522502, 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