{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:13:01Z","timestamp":1793193181681,"version":"4.5.0"},"reference-count":26,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>Background: Recently, chronic lung diseases have been found to be associated with marked inflammation and oxidative stress, which leads to fibrosis in the lungs and chronic respiratory failure. This study aims to determine if hydrogen-rich water (HRW) can enhance oxygen saturation among patients with chronic lung diseases. Methods: Ten patients with chronic lung diseases due to COPD (n = 7), bronchial asthma (n = 2), and tuberculosis of the lung (n = 1) with oxygen saturation of 90\u201395% were provided high-concentration (&gt;5 mM) HRW using H2-producing tablets for 4 weeks. Oxygen saturation was measured via oximeter and blood pressure via digital automatic BP recorder. Results: HRW administration was associated with a significant increase in oxygen saturation (SpO2) and decrease in TBARS, MDA, and diene conjugates, with an increase in vitamin E and nitrite levels, compared to baseline levels. Physical training carried out after HRW therapy appeared to increase exercise tolerance and decrease hypoxia, as well as delay the need for oxygen therapy. Conclusion: Treatment with HRW in patients with hypoxia from chronic lung diseases may decrease oxidative stress and improve oxygen saturation in some patients. HRW therapy may also provide increased exercise tolerance in patients with chronic hypoxia, but further research is needed.<\/jats:p>","DOI":"10.3390\/diseases11040127","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T03:45:23Z","timestamp":1695699923000},"page":"127","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Can Hydrogen Water Enhance Oxygen Saturation in Patients with Chronic Lung Disease? A Non-Randomized, Observational Pilot Study"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4922-0405","authenticated-orcid":false,"given":"Ram B.","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Medicine, Halberg Hospital and Research Institute, Moradabad 244001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0796-5345","authenticated-orcid":false,"given":"Alex","family":"Tarnava","sequence":"additional","affiliation":[{"name":"Natural Wellness Now Health Products Inc., Maple Ridge, BC V4R 2S6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8516-655X","authenticated-orcid":false,"given":"Ghizal","family":"Fatima","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Era\u2019s Lucknow Medical College and Hospital, Lucknow 226003, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4940-0393","authenticated-orcid":false,"given":"Jan","family":"Fedacko","sequence":"additional","affiliation":[{"name":"Centre of Clinical and Preclinical Research-MEDIPARK, Pavol Jozef Safarik University, 040 11 Kosice, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viliam","family":"Mojto","sequence":"additional","affiliation":[{"name":"Third Department of Internal Medicine, Faculty of Medicine, Comenius University, 813 72 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9164-6728","authenticated-orcid":false,"given":"Tyler W.","family":"LeBaron","sequence":"additional","affiliation":[{"name":"Molecular Hydrogen Institute, Cedar City, UT 84720, USA"},{"name":"Department of Kinesiology and Outdoor Recreation, Southern Utah University, Cedar, UT 84720, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,26]]},"reference":[{"key":"ref_1","unstructured":"(2023, January 24). 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