{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T10:53:00Z","timestamp":1772103180663,"version":"3.50.1"},"reference-count":48,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>A desmoid tumor (DT) is a rare benign neoplasm arising from muscle aponeurosis, associated mostly with trauma or pregnancy. DT has an infiltrative and locally aggressive growth pattern and usually does not metastasize. However, it has a high recurrence and complication rate. When it occurs in pregnancy, the pregnancy and delivery is taken as an individual case for optimal management by physicians and midwifes, who need to be cautious in finding the optimal delivery mode for the patient, which depends on the tumor size, location, behavior, and past history. The authors report a case of 29-year-old pregnant woman who previously underwent systemic oncological treatment for a large abdominal wall desmoid tumor and became pregnant afterwards. The history of DT presented a follow-up and delivery challenge. Observational management was chosen with an elective cesarean section at week 38 + 4 of pregnancy with uncomplicated postpartum follow-up. The authors detail the clinical management and chosen therapeutic approach; chemotherapy can be a choice in the treatment options for patients with DTs, although the majority of DTs are treated surgically with subsequent mesh plastic. Moreover, the authors provide a systematic review of the literature focused on the treatment management of DTs in pregnant women during pregnancy and the postpartum period, as pregnancy-associated desmoid tumors are a specific condition, where the optimal management is not well established, despite some guidelines for non-pregnant patients.<\/jats:p>","DOI":"10.3390\/diseases12010027","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T04:16:56Z","timestamp":1705465016000},"page":"27","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Desmoid Fibromatosis of the Anterior Abdominal Wall in Pregnancy: A Case Report and Review of the Literature"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1423-5556","authenticated-orcid":false,"given":"Pavol","family":"Zubor","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Nordland Hospital, 8450 Stokmarknes, Norway"},{"name":"OBGY Health & Care Ltd., 01001 Zilina, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline Marie","family":"Henriksen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Nordland Hospital, 8450 Stokmarknes, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maren Elvenes","family":"\u00d8kstad","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Nordland Hospital, 8450 Stokmarknes, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Cerskuviene","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Nordland Hospital, 8450 Stokmarknes, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jozef","family":"Visnovsky","sequence":"additional","affiliation":[{"name":"Faculty of Health Care, Catholic University, 03401 Ruzomberok, Slovakia"},{"name":"VISNOVSKI Ltd., 03601 Martin, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karol","family":"Kajo","sequence":"additional","affiliation":[{"name":"Department of Pathology, St. Elisabeth Cancer Institute, 81250 Bratislava, Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey","family":"Valkov","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, University Hospital of Northern Norway, 9019 Troms\u00f8, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen Olav","family":"Lind","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Nordland Hospital, 8450 Stokmarknes, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.suronc.2007.07.009","article-title":"Abdominal desmoid tumors","volume":"16","author":"Sakorafas","year":"2007","journal-title":"Surg. Oncol."},{"key":"ref_2","unstructured":"Hornick, J.L., Fritchle, K.J., and van de Rijn, M. (2020). Soft Tissue and Bone Tumours, International Agency for Research on Cancer. [5th ed.]. Available online: https:\/\/tumourclassification.iarc.who.int\/chapters\/33."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ejca.2016.02.008","article-title":"Management of desmoid tumours: A nationwide survey of labelled reference centre networks in France","volume":"58","author":"Penel","year":"2016","journal-title":"Eur. J. Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/ajcp\/77.6.665","article-title":"The desmoid tumor. I.: Incidence, sex-, age- and anatomical distribution in the Finnish population","volume":"77","author":"Reitamo","year":"1982","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"102114","DOI":"10.1016\/j.canep.2022.102114","article-title":"The epidemiology of desmoid tumors in Denmark","volume":"77","author":"Anneberg","year":"2022","journal-title":"Cancer Epidemiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"339","DOI":"10.21873\/cdp.10045","article-title":"The Clinical Features of Multicentric Extra-abdominal Desmoid Tumors","volume":"1","author":"Minami","year":"2021","journal-title":"Cancer Diagn. Progn."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s00266-017-0948-2","article-title":"Desmoid Tumor and Silicone Breast Implant Surgery: Is There Really a Connection? A Literature Review","volume":"42","author":"Tzur","year":"2017","journal-title":"Aesthetic Plast. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"M\u00fcller, J. (1835). Handbuch der Physiologie des Menschen, Biodiversity Heritage Library.","DOI":"10.5962\/bhl.title.128395"},{"key":"ref_9","unstructured":"(2022, October 27). Available online: https:\/\/www.wikidoc.org\/index.php\/Desmoid_tumor_historical_perspective."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"381","DOI":"10.21873\/anticanres.15496","article-title":"A Case of Mesenteric Desmoid Tumor Causing Bowel Obstruction After Laparoscopic Surgery","volume":"42","author":"Arima","year":"2022","journal-title":"Anticancer Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s40792-019-0587-8","article-title":"A case with mesenteric desmoid tumor after laparoscopic resection of stage I sigmoid colon cancer","volume":"5","author":"Takada","year":"2019","journal-title":"Surg. Case Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"rjab529","DOI":"10.1093\/jscr\/rjab529","article-title":"Mesenteric desmoid tumor after robot-assisted laparoscopic cystectomy with bladder replacement: A case report","volume":"2022","author":"Fukuhara","year":"2022","journal-title":"J. Surg. Case Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1477-7819-9-35","article-title":"A massive abdominal wall desmoid tumor occurring in a laparotomy scar: A case report","volume":"9","author":"Wanjeri","year":"2011","journal-title":"World J. Surg. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s40487-016-0017-z","article-title":"Intra-Abdominal and Abdominal Wall Desmoid Fibromatosis","volume":"4","author":"Howard","year":"2016","journal-title":"Oncol. Ther."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Garcia-Ortega, D.Y., Mart\u00edn-Tellez, K.S., Cuellar-Hubbe, M., Mart\u00ednez-Said, H., \u00c1lvarez-Cano, A., Brener-Chaoul, M., Alegr\u00eda-Ba\u00f1os, J.A., and Mart\u00ednez-Tlahuel, J.L. (2020). Desmoid-Type Fibromatosis. Cancers, 12.","DOI":"10.3390\/cancers12071851"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Napolitano, A., Mazzocca, A., Ceruso, M.S., Minelli, A., Baldo, F., Badalamenti, G., Silletta, M., Santini, D., Tonini, G., and Incorvaia, L. (2020). Recent Advances in Desmoid Tumor Therapy. Cancers, 12.","DOI":"10.3390\/cancers12082135"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1002\/1097-0142(197608)38:2<888::AID-CNCR2820380236>3.0.CO;2-R","article-title":"Tumors of fibrous tissue origin in childhood.A clinicopathologic study of cutaneous and soft tissue neoplasms in 66 children","volume":"38","author":"Dehner","year":"1976","journal-title":"Cancer"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1177\/000348949410300413","article-title":"Extra-abdominal desmoid fibromatosis","volume":"103","author":"Batsakis","year":"1994","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/ijc.25664","article-title":"A nation-wide study comparing sporadic and familial adenomatous polyposis-related desmoid-type fibromatoses","volume":"129","author":"Nieuwenhuis","year":"2011","journal-title":"Int. J. Cancer"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.bulcan.2019.10.011","article-title":"Familial adenomatous polyposis, desmoid tumors and Gardner syndrome","volume":"107","author":"Tayeb","year":"2020","journal-title":"Bull. Cancer"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1245\/s10434-016-5380-3","article-title":"Risk Factors for the Development of Desmoid Tumor After Colectomy in Patients with Familial Adenomatous Polyposis: Multicenter Retrospective Cohort Study in Japan","volume":"23","author":"Saito","year":"2016","journal-title":"Ann. Surg. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/cncr.22689","article-title":"Deep fibromatosis (desmoid tumor): Cytopathologic characteristics, clinicoradiologic features, and immunohistochemical findings on fine-needle aspiration","volume":"111","author":"Owens","year":"2007","journal-title":"Cancer"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3688","DOI":"10.4081\/ejh.2023.3688","article-title":"Clinicopathological assessment of PD-1\/PD-L1 immune checkpoint expression in desmoid tumors","volume":"67","author":"Hashimoto","year":"2023","journal-title":"Eur. J. Histochem."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Simonetti, I., Bruno, F., Fusco, R., Cutolo, C., Setola, S.V., Patrone, R., Masciocchi, C., Palumbo, P., Arrigoni, F., and Picone, C. (2022). Multimodality Imaging Assessment of Desmoid Tumors: The Great Mime in the Era of Multidisciplinary Teams. J. Pers. Med., 12.","DOI":"10.3390\/jpm12071153"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.hoc.2013.07.008","article-title":"Desmoid tumors: A comprehensive review of the evolving biology, unpredictable behavior, and myriad of management options","volume":"27","author":"Devata","year":"2013","journal-title":"Hematol. Oncol. Clin. N. Am."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e249966","DOI":"10.1136\/bcr-2022-249966","article-title":"Abdominal wall desmoid tumour in pregnancy","volume":"15","author":"Sulaiman","year":"2022","journal-title":"BMJ Case Rep."},{"key":"ref_27","first-page":"100","article-title":"Desmoid Tumor of the Rectus Abdominis with Urinary Bladder Involvement: A Case Report and Review of Literature","volume":"1","author":"Alfentoukh","year":"2023","journal-title":"Gulf J. Oncolog."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"880","DOI":"10.4103\/jcrt.JCRT_582_20","article-title":"Desmoid tumor of Meckel\u2019s diverticulum presenting as intestinal obstruction: A rare case report with literature review","volume":"18","author":"Mundada","year":"2022","journal-title":"J. Cancer Res. Ther."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1097\/SLA.0000000000000224","article-title":"Desmoid-type fibromatosis and pregnancy: A multi-institutional analysis of recurrence and obstetric risk","volume":"259","author":"Fiore","year":"2014","journal-title":"Ann. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"75","DOI":"10.14740\/wjon963w","article-title":"A Case of Spontaneous Regression of Recurrent Desmoid Tumor Originating From the Internal Obturator Muscle After Delivery","volume":"7","author":"Sueishi","year":"2016","journal-title":"World J. Oncol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Schut, A.-R.W., Lidington, E., Timbergen, M.J.M., Younger, E., van der Graaf, W.T.A., van Houdt, W.J., Bonenkamp, J.J., Jones, R.L., Gr\u00fcnhagen, D.J., and Sleijfer, S. (2022). Unraveling Desmoid-Type Fibromatosis-Specific Health-Related Quality of Life: Who Is at Risk for Poor Outcomes. Cancers, 14.","DOI":"10.3390\/cancers14122979"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/jso.21033","article-title":"Multimodality management of desmoid tumors: How important is a negative surgical margin?","volume":"98","author":"Melis","year":"2008","journal-title":"J. Surg. Oncol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1093\/annonc\/mdx323","article-title":"An update on the management of sporadic desmoid-type fibromatosis: A European Consensus Initiative between Sarcoma PAtients EuroNet (SPAEN) and European Organization for Research and Treatment of Cancer (EORTC)\/Soft Tissue and Bone Sarcoma Group (STBSG)","volume":"28","author":"Kasper","year":"2017","journal-title":"Ann. Oncol."},{"key":"ref_34","unstructured":"Desmoid Tumor Working Group (2020). The management of desmoid tumours: A joint global consensus-based guideline approach for adult and paediatric patients. Eur. J. Cancer, 127, 96\u2013107."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Testa, S., Bui, N.Q., Charville, G.W., Avedian, R.S., Steffner, R., Ghanouni, P., Mohler, D.G., and Ganjoo, K.N. (2022). Management of Patients with Newly Diagnosed Desmoid Tumors in a First-Line Setting. Cancers, 14.","DOI":"10.3390\/cancers14163907"},{"key":"ref_36","first-page":"100901","article-title":"Pregnancy-associated large pelvic desmoid tumor: A case report of fetal-protective strategies and fertility preservation","volume":"39","author":"Veerapong","year":"2021","journal-title":"Gynecol. Oncol. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Jin, L., Tan, Y., Su, Z., Huang, S., Pokhrel, S., Shi, H., and Chen, Y. (2020). Gardner syndrome with giant abdominal desmoid tumor during pregnancy: A case report. BMC Surg., 20.","DOI":"10.1186\/s12893-020-00944-z"},{"key":"ref_38","first-page":"339","article-title":"Case report: Rapidly growing abdominal wall giant desmoid tumour during pregnancy","volume":"85","year":"2017","journal-title":"Cir. Cir."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ijscr.2016.10.056","article-title":"Rapid progression of a pregnancy-associated intra-abdominal desmoid tumor in the post-partum period: A case report","volume":"29","author":"Hanna","year":"2016","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref_40","first-page":"350894","article-title":"Abdominal Wall Desmoid during Pregnancy: Diagnostic Challenges","volume":"2013","author":"Awwad","year":"2013","journal-title":"Case Rep. Obstet. Gynecol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"439","DOI":"10.5999\/aps.2012.39.4.439","article-title":"Desmoid tumor of the rectus abdominis muscle in a postpartum patient","volume":"39","author":"Choi","year":"2012","journal-title":"Arch. Plast. Surg."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/jso.20189","article-title":"Full-term gestation and transvaginal delivery after wide resection of an abdominal desmoid tumor during pregnancy","volume":"89","author":"Durkin","year":"2005","journal-title":"J. Surg. Oncol."},{"key":"ref_43","first-page":"153","article-title":"Management of a large abdominal wall desmoid tumor during pregnancy","volume":"81","author":"Michopoulou","year":"2010","journal-title":"Case Report. Ann. Ital. Chir."},{"key":"ref_44","first-page":"S72","article-title":"A large abdominal desmoid tumor associated with pregnancy","volume":"92","author":"Viriyaroj","year":"2009","journal-title":"J. Med. Assoc. Thai."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4137\/CCRep.S13593","article-title":"Desmoid tumor in puerperium period: A case report","volume":"7","author":"Gurluler","year":"2014","journal-title":"Clin. Med. Insights Case Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"253","DOI":"10.12891\/ceog1832.2015","article-title":"Abdominal wall desmoid tumor during pregnancy: Case report and literature review","volume":"42","author":"Zhou","year":"2015","journal-title":"Clin. Exp. Obstet. Gynecol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"100578","DOI":"10.1016\/j.esmoop.2022.100578","article-title":"Association between recent pregnancy or hormonal contraceptive exposure and outcome of desmoid-type fibromatosis","volume":"7","author":"Debaudringhien","year":"2022","journal-title":"ESMO Open"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s10147-014-0743-x","article-title":"Pregnancy does not increase the local recurrence rate after surgical resection of desmoid-type fibromatosis","volume":"20","author":"Cates","year":"2014","journal-title":"Int. J. Clin. Oncol."}],"container-title":["Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-9721\/12\/1\/27\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:48:24Z","timestamp":1760104104000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-9721\/12\/1\/27"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,17]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["diseases12010027"],"URL":"https:\/\/doi.org\/10.3390\/diseases12010027","relation":{},"ISSN":["2079-9721"],"issn-type":[{"value":"2079-9721","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,17]]}}}