{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T12:07:00Z","timestamp":1770466020717,"version":"3.49.0"},"reference-count":75,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T00:00:00Z","timestamp":1707436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001350","name":"Singapore National Medical Research Council","doi-asserted-by":"publisher","award":["MOH-CSAINV21jun-0001"],"award-info":[{"award-number":["MOH-CSAINV21jun-0001"]}],"id":[{"id":"10.13039\/501100001350","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>Introduction: This is a case report of a patient with neuropathic corneal pain after coronavirus disease 2019 (COVID-19) infection. Methods: A previously healthy 27-year-old female presented with bilateral eye pain accompanied by increased light sensitivity 5 months after COVID-19 infection. She was diagnosed with neuropathic corneal pain based on clear corneas without fluorescein staining, alongside the presence of microneuromas, dendritic cells, and activated stromal keratocytes identified bilaterally on in vivo confocal microscopy. Results: The patient\u2019s tear nerve growth factor, substance P, and calcitonin gene-related peptide levels were 5.9 pg\/mL, 2978.7 pg\/mL, and 1.1 ng\/mL, respectively, for the right eye and 23.1 pg\/mL, 4798.7 pg\/mL, and 1.2 ng\/mL, respectively, for the left eye, suggesting corneal neuroinflammatory status. After 6 weeks of topical 0.1% flurometholone treatment, decreased microneuroma size, less extensive dendritic cells, and reduced tear nerve growth factor and substance P levels were observed. The scores on the Ocular Pain Assessment Survey showed an improvement in burning sensation and light sensitivity, decreasing from 80% and 70% to 50% for both. Conclusions: Neuropathic corneal pain is a potential post-COVID-19 complication that warrants ophthalmologists\u2019 and neurologists\u2019 attention.<\/jats:p>","DOI":"10.3390\/diseases12020037","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T08:12:03Z","timestamp":1707466323000},"page":"37","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Neuropathic Corneal Pain after Coronavirus Disease 2019 (COVID-19) Infection"],"prefix":"10.3390","volume":"12","author":[{"given":"Natalie Shi Qi","family":"Wong","sequence":"first","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute, Singapore 169856, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Molly Tzu-Yu","family":"Lin","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute, Singapore 169856, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle Xin Yu","family":"Lee","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute, Singapore 169856, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis","family":"Tong","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute, Singapore 169856, Singapore"},{"name":"Department of Cornea and External Eye Disease, Singapore National Eye Centre, Singapore 168751, Singapore"},{"name":"Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore 169857, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5408-0382","authenticated-orcid":false,"given":"Yu-Chi","family":"Liu","sequence":"additional","affiliation":[{"name":"Singapore Eye Research Institute, Singapore 169856, Singapore"},{"name":"Department of Cornea and External Eye Disease, Singapore National Eye Centre, Singapore 168751, Singapore"},{"name":"Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore 169857, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,9]]},"reference":[{"key":"ref_1","unstructured":"(2022, November 15). 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