{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:56:23Z","timestamp":1789419383841,"version":"build-2803163510"},"reference-count":19,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cVICTOR BABES\u201d UNIVERSITY OF MEDICINE AND PHARMACY TIMISOARA"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>Pancreaticolithiasis represents a rare phenomenon, being superimposed most of the time on a form of chronic pancreatitis of multifactorial etiology. Pancreaticolithiasis is a late complication of the phenomenon of chronic pancreatitis. The reverberant inflammatory process, followed by the fibrotic degeneration of the pancreatic parenchyma, and pancreatic fluid stasis at the ductal level are factors that contribute to the phenomenon of calcium precipitation. This article describes the case of a patient with a diagnosis of pancreaticolithiasis (Wirsung duct lithiasis), a phenomenon superimposed on chronic pancreatitis of ethanolic cause (Rosemont classification). It was decided to perform surgery via the classical approach with the perfection of corporeo-caudal pancreatectomy and preservation of the splenic vessels (Kimura procedure) with pancreatico-jejunal anastomosis on the Roux-en-Y loop. The aim of this study is to identify the best method of treatment for pancreaticolithiasis. To enhance the case and provide a basis for standardization, a literature review was carried out, which included a total of six articles. The results of this study highlight that, currently, the management of symptomatic pancreaticolithiasis encompasses medical therapy (enzyme replacement therapy), interventional therapy (ESWL (extracorporeal shock wave lithotripsy) \u00b1 ERCP (endoscopic retrograde cholangiopancreatography), ERCP + sphincterotomy + stent insertion, and POP (oral pancreatoscopy)), and surgical treatment. In conclusion, based on the analysis conducted in this study, the size of the calculi present determines which is the suitable therapeutic care. Unlike stones over 0.5 cm, when surgery is explicitly advised for therapeutic purposes in the absence of endoscopic techniques, stones under 0.5 cm should be treated using endoscopic procedures.<\/jats:p>","DOI":"10.3390\/diseases12050086","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T08:42:57Z","timestamp":1714639377000},"page":"86","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Surgical Treatment of Lithiasis of the Main Pancreatic Duct: A Challenging Case and a Literature Review"],"prefix":"10.3390","volume":"12","author":[{"given":"Dan","family":"Brebu","sequence":"first","affiliation":[{"name":"2nd Surgery Clinic, Timi\u0219oara Emergency County Hospital, 300723 Timisoara, Romania"},{"name":"X Department of General Surgery, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4348-5469","authenticated-orcid":false,"given":"C\u0103t\u0103lin","family":"Prodan-B\u0103rbulescu","sequence":"additional","affiliation":[{"name":"2nd Surgery Clinic, Timi\u0219oara Emergency County Hospital, 300723 Timisoara, Romania"},{"name":"Department I, Discipline of Anatomy and Embriology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041, Timisoara, Romania"},{"name":"Doctoral School, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vlad","family":"Braicu","sequence":"additional","affiliation":[{"name":"2nd Surgery Clinic, Timi\u0219oara Emergency County Hospital, 300723 Timisoara, Romania"},{"name":"X Department of General Surgery, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"},{"name":"Doctoral School, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Pa\u0219ca","sequence":"additional","affiliation":[{"name":"2nd Surgery Clinic, Timi\u0219oara Emergency County Hospital, 300723 Timisoara, Romania"},{"name":"X Department of General Surgery, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"},{"name":"Doctoral School, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Borcean","sequence":"additional","affiliation":[{"name":"2nd Surgery Clinic, Timi\u0219oara Emergency County Hospital, 300723 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Florea","sequence":"additional","affiliation":[{"name":"Department of Medical\u2014Clinical Disciplines, Faculty of Medicine, \u201cTitu Maiorescu\u201d University of Bucharest, 031593 Bucharest, Romania"},{"name":"Medicine Doctoral School, \u201cTitu Maiorescu\u201d University of Bucharest, 031593 Bucharest, Romania"},{"name":"Department of General Surgery, Monza Clinical Hospital, 021967 Bucharest, Romania"},{"name":"Department of General Surgery, Sanador Clinical Hospital, 010991 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarisa","family":"B\u00eerlog","sequence":"additional","affiliation":[{"name":"Department of Surgery, Ponderas Academic Hospital, 021188 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5736-572X","authenticated-orcid":false,"given":"Amadeus","family":"Dobrescu","sequence":"additional","affiliation":[{"name":"2nd Surgery Clinic, Timi\u0219oara Emergency County Hospital, 300723 Timisoara, Romania"},{"name":"X Department of General Surgery, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u0103rioara","family":"Cornianu","sequence":"additional","affiliation":[{"name":"Department of Microscopic Morphology-Morphopatology, ANAPATMOL Research Center, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"},{"name":"Department of Pathology, \u201cPius Brinzeu\u201d County Clinical Emergency Hospital, 300723 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulger","family":"Laz\u0103r","sequence":"additional","affiliation":[{"name":"2nd Surgery Clinic, Timi\u0219oara Emergency County Hospital, 300723 Timisoara, Romania"},{"name":"X Department of General Surgery, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan","family":"Totolici","sequence":"additional","affiliation":[{"name":"1st Clinic of General Surgery, Arad County Emergency Clinical Hospital, 310158 Arad, Romania"},{"name":"Department of General Surgery, Faculty of Medicine, \u201cVasile Goldis\u201d Western University of Arad, 310025 Arad, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciprian","family":"Du\u021b\u0103","sequence":"additional","affiliation":[{"name":"2nd Surgery Clinic, Timi\u0219oara Emergency County Hospital, 300723 Timisoara, Romania"},{"name":"X Department of General Surgery, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6451-7461","authenticated-orcid":false,"given":"Flaviu Ionu\u021b","family":"Faur","sequence":"additional","affiliation":[{"name":"2nd Surgery Clinic, Timi\u0219oara Emergency County Hospital, 300723 Timisoara, Romania"},{"name":"X Department of General Surgery, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"},{"name":"Multidisciplinary Doctoral School \u201cVasile Goldis\u201d, Western University of Arad, 310025 Arad, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,30]]},"reference":[{"key":"ref_1","unstructured":"Mukherjee, S. 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