{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T23:26:01Z","timestamp":1788564361946,"version":"build-2803163510"},"reference-count":64,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>Cellular metabolism, apoptosis, fertilization, and proliferation of granulosa cells belong to a battery of processes where microRNAs can be detected and associated with infertility. The aim of the present review is to focus on mammalian oocyte maturation events and the association between oocyte growth and miRNA expression. PubMed\/Medline, Google Scholar and Scopus databases were searched, and 33 studies were included. Regarding the correlation among miRNA expression and the regulation of granulosa cells and cumulus cells, the most important miRNAs were let-7b, let-7c and miR-21. Additionally, the loss of Dicer, an enzyme involved in miRNA biogenesis, is probably a crucial factor in oogenesis, oocyte maturation and embryogenesis. Furthermore, miRNAs interfere with different cellular mechanisms like apoptosis, steroidogenesis, genome integrity, angiogenesis, antioxidative response and, consequently, oocyte maturation. Hence, it is of major importance to clarify the role and mechanism of each miRNA as understanding its action may develop new tools and establish new diagnostic and treatment approaches for infertility and ovarian disorders.<\/jats:p>","DOI":"10.3390\/diseases12060121","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T08:43:54Z","timestamp":1717577034000},"page":"121","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Oocyte Maturation and miRNAs: Studying a Complicate Interaction to Reveal Possible Biomarkers for Female Infertility"],"prefix":"10.3390","volume":"12","author":[{"given":"Eleni","family":"Nazou","sequence":"first","affiliation":[{"name":"Third Department of Obstetrics and Gynecology, University General Hospital \u201cATTIKON\u201d, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7716-1521","authenticated-orcid":false,"given":"Anastasios","family":"Potiris","sequence":"additional","affiliation":[{"name":"Third Department of Obstetrics and Gynecology, University General Hospital \u201cATTIKON\u201d, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Despoina","family":"Mavrogianni","sequence":"additional","affiliation":[{"name":"First Department of Obstetrics and Gynecology, Alexandra Hospital, Medical School, National and Kapodistrian University of Athens, 115 28 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eirini","family":"Drakaki","sequence":"additional","affiliation":[{"name":"First Department of Obstetrics and Gynecology, Alexandra Hospital, Medical School, National and Kapodistrian University of Athens, 115 28 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aris-Anargyros","family":"Vogiatzis","sequence":"additional","affiliation":[{"name":"Third Department of Obstetrics and Gynecology, University General Hospital \u201cATTIKON\u201d, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaia","family":"Sarli","sequence":"additional","affiliation":[{"name":"Third Department of Obstetrics and Gynecology, University General Hospital \u201cATTIKON\u201d, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tereza","family":"Vrantza","sequence":"additional","affiliation":[{"name":"Third Department of Obstetrics and Gynecology, University General Hospital \u201cATTIKON\u201d, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Zikopoulos","sequence":"additional","affiliation":[{"name":"Third Department of Obstetrics and Gynecology, University General Hospital \u201cATTIKON\u201d, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8391-0850","authenticated-orcid":false,"given":"Konstantinos","family":"Louis","sequence":"additional","affiliation":[{"name":"Third Department of Obstetrics and Gynecology, University General Hospital \u201cATTIKON\u201d, Medical School, National and Kapodistrian University of Athens, 124 62 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chara","family":"Skentou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Medical School, University of Ioannina, 45110 Ioannina, 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Endocrinol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/humupd\/dmi006","article-title":"Fertility and ageing","volume":"11","author":"Baird","year":"2005","journal-title":"Hum. Reprod. Update"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1210\/edrv-17-2-121","article-title":"Regulation of ovarian follicular development in primates: Facts and hypotheses","volume":"17","author":"Gougeon","year":"1996","journal-title":"Endocr. Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1095\/biolreprod.104.037069","article-title":"Identification of novel and known oocyte-specific genes using complementary DNA subtraction and microarray analysis in three different species","volume":"73","author":"Vallee","year":"2005","journal-title":"Biol. Reprod."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1095\/biolreprod.102.007872","article-title":"Use of heterologous complementary DNA array screening to analyze bovine oocyte transcriptome and its evolution during in vitro maturation","volume":"68","author":"Mermillod","year":"2003","journal-title":"Biol. Reprod."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0303-7207(01)00699-2","article-title":"The initiation of follicle growth: The oocyte or the somatic cells?","volume":"187","year":"2002","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1007\/s10815-018-1180-y","article-title":"Biomechanics and mechanical signaling in the ovary: A systematic review","volume":"35","author":"Shah","year":"2018","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/978-1-4684-5395-9_14","article-title":"Estrogen-producing ovarian granulosa cells: Use of the granulosa cell aromatase bioassay (GAB) to monitor FSH levels in body fluids","volume":"219","author":"Dahl","year":"1987","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/jez.1402080112","article-title":"Gonadotropin stimulation of the expansion of cumulus oophori isolated from mice: General conditions for expansion in vitro","volume":"208","author":"Eppig","year":"1979","journal-title":"J. Exp. Zool."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.1016\/j.jmb.2013.03.007","article-title":"The role of miRNAs in regulating gene expression networks","volume":"425","author":"Gurtan","year":"2013","journal-title":"J. Mol. Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"D140","DOI":"10.1093\/nar\/gkj112","article-title":"miRBase: MicroRNA sequences, targets and gene nomenclature","volume":"34","author":"Grocock","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1126\/science.1080372","article-title":"Vertebrate microRNA genes","volume":"299","author":"Lim","year":"2003","journal-title":"Science"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1126\/science.1062961","article-title":"A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA","volume":"293","author":"Hutvagner","year":"2001","journal-title":"Science"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature01957","article-title":"The nuclear RNase III Drosha initiates microRNA processing","volume":"425","author":"Lee","year":"2003","journal-title":"Nature"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"5726","DOI":"10.1093\/nar\/gky248","article-title":"Microprocessor depends on hemin to recognize the apical loop of primary microRNA","volume":"46","author":"Nguyen","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1017\/S0967199411000566","article-title":"Expression analysis of regulatory microRNAs in bovine cumulus oocyte complex and preimplantation embryos","volume":"21","author":"Hagos","year":"2013","journal-title":"Zygote"},{"key":"ref_17","first-page":"161","article-title":"The Role of MicroRNAs in Human Diseases","volume":"2","author":"Ardekani","year":"2010","journal-title":"Avicenna J. Med. Biotechnol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1093\/humrep\/deaa364","article-title":"Age-related miRNome landscape of cumulus oophorus cells during controlled ovarian stimulation protocols in IVF cycles","volume":"36","author":"Cuomo","year":"2021","journal-title":"Hum. Reprod."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Gonella-Diaza, A.M., Lopes, E., Ribeiro da Silva, K., Perecin Nociti, R., Mamede Andrade, G., Atuesta-Bustos, J.E., Coelho da Silveira, J., Vieira Meirelles, F., and Binelli, M. (2021). Steroidal Regulation of Oviductal microRNAs Is Associated with microRNA-Processing in Beef Cows. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22020953"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nrg1379","article-title":"MicroRNAs: Small RNAs with a big role in gene regulation","volume":"5","author":"He","year":"2004","journal-title":"Nat. Rev. Genet."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.fertnstert.2013.10.042","article-title":"MicroRNA: Key gene expression regulators","volume":"101","author":"Vilella","year":"2014","journal-title":"Fertil. Steril."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1038\/sj.mt.6300311","article-title":"MicroRNAs in disease and potential therapeutic applications","volume":"15","author":"Soifer","year":"2007","journal-title":"Mol. Ther."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1016\/j.fertnstert.2014.04.030","article-title":"Introduction: MicroRNAs in human reproduction: Small molecules with crucial regulatory roles","volume":"101","author":"Imbar","year":"2014","journal-title":"Fertil. Steril."},{"key":"ref_24","first-page":"275","article-title":"Advance on Dicer gene and its role in female reproduction","volume":"28","author":"Li","year":"2011","journal-title":"Chin. J. Med. Genet."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1095\/biolreprod63.3.805","article-title":"Protection of porcine oocytes against apoptotic cell death caused by oxidative stress during In vitro maturation: Role of cumulus cells","volume":"63","author":"Tatemoto","year":"2000","journal-title":"Biol. Reprod."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Dompe, C., Kulus, M., Stefanska, K., Kranc, W., Chermula, B., Bryl, R., Pienkowski, W., Nawrocki, M.J., Petitte, J.N., and Stelmach, B. (2021). Human Granulosa Cells-Stemness Properties, Molecular Cross-Talk and Follicular Angiogenesis. Cells, 10.","DOI":"10.3390\/cells10061396"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.mce.2011.07.049","article-title":"Oogenesis: Transcriptional regulators and mouse models","volume":"356","author":"Jagarlamudi","year":"2012","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"da Silveira, J.C., Veeramachaneni, D.N., Winger, Q.A., Carnevale, E.M., and Bouma, G.J. (2012). Cell-secreted vesicles in equine ovarian follicular fluid contain miRNAs and proteins: A possible new form of cell communication within the ovarian follicle. Biol. Reprod., 86.","DOI":"10.1095\/biolreprod.111.093252"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/jcp.21999","article-title":"Identification of microRNAs controlling human ovarian cell proliferation and apoptosis","volume":"223","author":"Sirotkin","year":"2010","journal-title":"J. Cell. Physiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.fertnstert.2015.07.001","article-title":"Follicular fluid and mural granulosa cells microRNA profiles vary in in vitro fertilization patients depending on their age and oocyte maturation stage","volume":"104","author":"Moreno","year":"2015","journal-title":"Fertil. Steril."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1751\u20131761.e1","DOI":"10.1016\/j.fertnstert.2014.08.005","article-title":"Molecular characterization of exosomes and their microRNA cargo in human follicular fluid: Bioinformatic analysis reveals that exosomal microRNAs control pathways involved in follicular maturation","volume":"102","author":"Santonocito","year":"2014","journal-title":"Fertil. Steril."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s11783-013-0490-7","article-title":"MiRNA-451 is a potential biomarker for estrogenicity in mouse uterus","volume":"8","author":"Hou","year":"2014","journal-title":"Front. Environ. Sci. Eng."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1530\/REP-11-0371","article-title":"Differentially expressed plasma microRNAs in premature ovarian failure patients and the potential regulatory function of mir-23a in granulosa cell apoptosis","volume":"144","author":"Yang","year":"2012","journal-title":"Reproduction"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1093\/humrep\/det321","article-title":"MicroRNAs: New candidates for the regulation of the human cumulus-oocyte complex","volume":"28","author":"Assou","year":"2013","journal-title":"Hum. Reprod."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2174\/2211536607666180912152618","article-title":"Differential miRNA Expression Profiles in Cumulus and Mural Granulosa Cells from Human Pre-ovulatory Follicles","volume":"8","author":"Andrei","year":"2019","journal-title":"Microrna"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1038\/s41598-023-28686-x","article-title":"Evaluation of the potential of miR-21 as a diagnostic marker for oocyte maturity and embryo quality in women undergoing ICSI","volume":"13","author":"Jenabi","year":"2023","journal-title":"Sci. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1002\/cbin.11036","article-title":"Clinical correlation of apoptosis in human granulosa cells-A review","volume":"42","author":"Almeida","year":"2018","journal-title":"Cell Biol. Int."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1095\/biolreprod.109.081448","article-title":"MicroRNA 21 blocks apoptosis in mouse periovulatory granulosa cells","volume":"83","author":"Carletti","year":"2010","journal-title":"Biol. Reprod."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1093\/biolre\/iox044","article-title":"MicroRNA-21 plays a pivotal role in the oocyte-secreted factor-induced suppression of cumulus cell apoptosis","volume":"96","author":"Han","year":"2017","journal-title":"Biol. Reprod."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1093\/biolre\/ioaa058","article-title":"MicroRNA-21 as a regulator of human cumulus cell viability and its potential influence on the developmental potential of the oocyte","volume":"103","author":"Bartolucci","year":"2020","journal-title":"Biol. Reprod."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3892\/etm.2021.9674","article-title":"Ovarian endometriosis, a precursor of ovarian cancer: Histological aspects, gene expression and microRNA alterations (Review)","volume":"21","author":"Braicu","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.bbrc.2020.11.058","article-title":"Association of exosomal microRNAs in human ovarian follicular fluid with oocyte quality","volume":"534","author":"Zhang","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1093\/carcin\/bgx126","article-title":"MiRNA-513a-5p inhibits progesterone receptor expression and constitutes a risk factor for breast cancer: The hOrmone and Diet in the ETiology of breast cancer prospective study","volume":"39","author":"Muti","year":"2018","journal-title":"Carcinogenesis"},{"key":"ref_44","first-page":"279","article-title":"miR-505-3p is a repressor of the puberty onset in female mice","volume":"240","author":"Zhou","year":"2018","journal-title":"J. Endocrinol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1093\/molehr\/gax033","article-title":"The transcriptome of human oocytes is related to age and ovarian reserve","volume":"23","author":"Barragan","year":"2017","journal-title":"Mol. Hum. Reprod."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"8689","DOI":"10.1038\/srep08689","article-title":"MiRNA-320 in the human follicular fluid is associated with embryo quality in vivo and affects mouse embryonic development in vitro","volume":"5","author":"Feng","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s10815-017-0876-8","article-title":"Extracellular microRNAs in follicular fluid and their potential association with oocyte fertilization and embryo quality: An exploratory study","volume":"34","author":"Machtinger","year":"2017","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1210\/jc.2013-1715","article-title":"Identification of microRNAs in human follicular fluid: Characterization of microRNAs that govern steroidogenesis in vitro and are associated with polycystic ovary syndrome in vivo","volume":"98","author":"Sang","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.mce.2011.11.002","article-title":"Novel signaling mechanisms in the ovary during oocyte maturation and ovulation","volume":"356","author":"Conti","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Al-Edani, T., Assou, S., Ferrieres, A., Bringer Deutsch, S., Gala, A., Lecellier, C.H., Ait-Ahmed, O., and Hamamah, S. (2014). Female aging alters expression of human cumulus cells genes that are essential for oocyte quality. Biomed. Res. Int., 2014.","DOI":"10.1155\/2014\/964614"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/mrd.23698","article-title":"The expression levels of NOS2, HMOX1, and VEGFC in cumulus cells are markers of oocyte maturation and fertilization rate","volume":"90","author":"Barragan","year":"2023","journal-title":"Mol. Reprod. Dev."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1016\/j.febslet.2012.06.048","article-title":"MicroRNA-145 suppresses mouse granulosa cell proliferation by targeting activin receptor IB","volume":"586","author":"Yan","year":"2012","journal-title":"FEBS Lett."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"4497","DOI":"10.1016\/j.febslet.2014.10.021","article-title":"MiR-92a inhibits porcine ovarian granulosa cell apoptosis by targeting Smad7 gene","volume":"588","author":"Liu","year":"2014","journal-title":"FEBS Lett."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13048-017-0336-1","article-title":"MicroRNA-130b is involved in bovine granulosa and cumulus cells function, oocyte maturation and blastocyst formation","volume":"10","author":"Sinha","year":"2017","journal-title":"J. Ovarian Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.biocel.2015.08.011","article-title":"Let-7g induces granulosa cell apoptosis by targeting MAP3K1 in the porcine ovary","volume":"68","author":"Cao","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.7150\/ijbs.68028","article-title":"Mir-484 contributes to diminished ovarian reserve by regulating granulosa cell function via YAP1-mediated mitochondrial function and apoptosis","volume":"18","author":"Li","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1071\/RD9960485","article-title":"Coordination of nuclear and cytoplasmic oocyte maturation in eutherian mammals","volume":"8","author":"Eppig","year":"1996","journal-title":"Reprod. Fertil. Dev."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1242\/dev.039487","article-title":"Maternal control of early mouse development","volume":"137","author":"Li","year":"2010","journal-title":"Development"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1172\/JCI33680","article-title":"Impaired microRNA processing causes corpus luteum insufficiency and infertility in mice","volume":"118","author":"Otsuka","year":"2008","journal-title":"J. Clin. Investig."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/ng1253","article-title":"Dicer is essential for mouse development","volume":"35","author":"Bernstein","year":"2003","journal-title":"Nat. Genet."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"9330","DOI":"10.1074\/jbc.M413394200","article-title":"Dicer is required for embryonic angiogenesis during mouse development","volume":"280","author":"Yang","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1101\/gad.1521307","article-title":"Critical roles for Dicer in the female germline","volume":"21","author":"Murchison","year":"2007","journal-title":"Genes Dev."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1101\/gad.418707","article-title":"Maternal microRNAs are essential for mouse zygotic development","volume":"21","author":"Tang","year":"2007","journal-title":"Genes Dev."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s10815-010-9456-x","article-title":"Dicer is a key player in oocyte maturation","volume":"27","author":"Liu","year":"2010","journal-title":"J. Assist. Reprod. Genet."}],"container-title":["Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-9721\/12\/6\/121\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:53:19Z","timestamp":1760107999000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-9721\/12\/6\/121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,4]]},"references-count":64,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["diseases12060121"],"URL":"https:\/\/doi.org\/10.3390\/diseases12060121","relation":{},"ISSN":["2079-9721"],"issn-type":[{"value":"2079-9721","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,4]]}}}