{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T12:25:01Z","timestamp":1793881501720,"version":"4.7.0"},"reference-count":37,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cVictor Babes\u201d University of Medicine and Pharmacy, Timisoara, Romania"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>This cross-sectional analysis aimed to assess the quality of life (QoL) among hospitalized patients with alcohol use disorder (AUD) in Romania, utilizing the WHOQOL survey. Conducted from January to December 2023 in the Psychiatry Clinic of the \u201cPius Brinzeu\u201d Emergency Clinical Hospital in Timisoara, this study engaged 70 participants, adhering to ethical standards outlined in the Declaration of Helsinki. Employing the WHOQOL-BREF instrument, the research hypothesized that AUD patients would show significantly lower QoL scores across its domains compared to general population norms. The study focused on identifying the QoL domains most impacted by AUD, exploring correlations between QoL scores and AUD background characteristics, and pinpointing intervention areas for patient care improvement. Participants were predominantly males (88.57%) with a middle-aged average of 55.51 years. Educational backgrounds varied, with a notable percentage having attended college (44.29%) or university (17.14%). Regarding marital status, 41.43% were married. Comorbidities were present in 52.86% of the sample, with hypertension being the most common (34.29%). Results showed mean QoL scores in the physical (61.84 \u00b1 16.05), psychological (64.11 \u00b1 17.16), social (60.48 \u00b1 24.85), and environmental (68.44 \u00b1 17.34) domains, revealing a significant diversity in satisfaction levels across these areas. Statistical analyses highlighted marital status as significantly associated with a better QoL in the physical domain, with married, co-habiting, and divorced participants reporting higher scores compared to single ones. In conclusion, while AUD significantly affects the QoL of hospitalized patients in Romania, marital status emerges as a critical factor in mitigating these effects, particularly in the physical domain of QoL. These findings underscore the complexity of AUD\u2019s impact on QoL and the importance of considering sociodemographic factors in patient care practices and interventions. The study contributes valuable insights into the nuanced relationship between AUD and QoL, proposing a foundation for enhancing care outcomes for AUD patients in Romania.<\/jats:p>","DOI":"10.3390\/diseases12070158","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T15:05:51Z","timestamp":1721142351000},"page":"158","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Quality of Life Assessment Using the WHOQOL-BREF Survey in Hospitalized Patients with Alcohol Use Disorder from Romania"],"prefix":"10.3390","volume":"12","author":[{"given":"Melania Lavinia","family":"Bratu","sequence":"first","affiliation":[{"name":"Center for Neuropsychology and Behavioral Medicine, Department of Psychology, Faculty of General Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania"},{"name":"Doctoral School, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania"},{"name":"Center for Cognitive Research in Neuropsychiatric Pathology, Department of Neurosciences, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorel","family":"Sandesc","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teodora","family":"Anghel","sequence":"additional","affiliation":[{"name":"Department of Neurosciences-Psychiatry, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania"},{"name":"Methodological and Infectious Diseases Research Center, Department of Infectious Diseases, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liana","family":"Dehelean","sequence":"additional","affiliation":[{"name":"Center for Cognitive Research in Neuropsychiatric Pathology, Department of Neurosciences, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania"},{"name":"Department of Neurosciences-Psychiatry, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0852-3503","authenticated-orcid":false,"given":"Mariana","family":"Bondrescu","sequence":"additional","affiliation":[{"name":"Center for Cognitive Research in Neuropsychiatric Pathology, Department of Neurosciences, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania"},{"name":"Department of Neurosciences-Psychiatry, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4711-4315","authenticated-orcid":false,"given":"Felix","family":"Bratosin","sequence":"additional","affiliation":[{"name":"Methodological and Infectious Diseases Research Center, Department of Infectious Diseases, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1971-6901","authenticated-orcid":false,"given":"Raluca","family":"Tudor","sequence":"additional","affiliation":[{"name":"Second Discipline of Neurology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2147\/SAR.S409943","article-title":"Neurobiology and the Treatment of Alcohol Use Disorder: A Review of the Evidence Base","volume":"14","author":"Donato","year":"2023","journal-title":"Subst. Abuse Rehabil."},{"key":"ref_2","unstructured":"Nehring, S.M., Chen, R.J., and Freeman, A.M. (2024). Alcohol Use Disorder. StatPearls, StatPearls Publishing."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1176\/appi.ajp.2020.20050610","article-title":"The World Health Organization Risk Drinking Levels Measure of Alcohol Consumption: Prevalence and Health Correlates in Nationally Representative Surveys of U.S. Adults, 2001\u20132002 and 2012\u20132013","volume":"178","author":"Shmulewitz","year":"2021","journal-title":"Am. J. Psychiatry"},{"key":"ref_4","first-page":"135","article-title":"The risks associated with alcohol use and alcoholism","volume":"34","author":"Rehm","year":"2011","journal-title":"Alcohol Res. Health"},{"key":"ref_5","first-page":"5","article-title":"Classification of alcohol use disorders","volume":"27","author":"Hasin","year":"2003","journal-title":"Alcohol Res. Health"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"91","DOI":"10.5114\/jhi.2021.113167","article-title":"Alcohol and health in Central and Eastern European Union countries\u2014Status quo and alcohol policy options","volume":"7","author":"Rehm","year":"2021","journal-title":"J. Health Inequal."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Jakovljevic, M.B., Jovanovic, M., and Lesch, O.M. (2015). Accessibility and affordability of alcohol dependency medical care in serbia. Front. Psychiatry, 5.","DOI":"10.3389\/fpsyt.2014.00192"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"ckac130.190","DOI":"10.1093\/eurpub\/ckac130.190","article-title":"Burden of alcohol use disorder in Balkan countries","volume":"32","author":"Todorovic","year":"2022","journal-title":"Eur. J. Public. Health"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4103\/0972-6748.123617","article-title":"Quality of life as an outcome measure in the treatment of alcohol dependence","volume":"22","author":"Srivastava","year":"2013","journal-title":"Ind. Psychiatry J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1037\/ccp0000750","article-title":"Mechanisms of quality-of-life improvement in treatment for alcohol use disorder","volume":"90","author":"Carlon","year":"2022","journal-title":"J. Consult. Clin. Psychol."},{"key":"ref_11","first-page":"140","article-title":"World Health Organization Quality-of-Life Scale (WHOQOL-BREF): Analyses of Their Item Response Theory Properties Based on the Graded Responses Model","volume":"5","author":"Vahedi","year":"2010","journal-title":"Iran. J. Psychiatry"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s11136-020-02661-9","article-title":"Enhancing the multi-dimensional assessment of quality of life: Introducing the WHOQOL-Combi","volume":"30","author":"Skevington","year":"2021","journal-title":"Qual. Life Res."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Ramji, R., R\u00e4mg\u00e5rd, M., and Kottorp, A. (2023). Psychometric properties of the WHOQOL-BREF in citizens from a disadvantaged neighborhood in Southern Sweden. Front. Psychol., 14.","DOI":"10.3389\/fpsyg.2023.1118575"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s12955-022-02012-x","article-title":"Health-related quality of life and influencing factors in drug addicts based on the scale QLICD-DA: A cross-sectional study","volume":"20","author":"Ma","year":"2022","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e29699","DOI":"10.1097\/MD.0000000000029699","article-title":"Characteristics and quality of life of substance users and their caregivers","volume":"101","author":"Maksimovic","year":"2022","journal-title":"Medicine"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Tarekegn, G.E., Nenko, G., Tilahun, S.Y., Kassew, T., Demilew, D., Oumer, M., Alemu, K., Yesuf, Y.M., Getnet, B., and Melkam, M. (2022). Quality of life and associated factors among the youth with substance use in Northwest Ethiopia: Using structural equation modeling. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0274768"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"N\u0103sui, B.A., Ungur, R.A., Talaba, P., Varlas, V.N., Ciuciuc, N., Silaghi, C.A., Silaghi, H., Opre, D., and Pop, A.L. (2021). Is Alcohol Consumption Related to Lifestyle Factors in Romanian University Students?. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18041835"},{"key":"ref_18","unstructured":"GBD 2016 Alcohol Collaborators (2018). Alcohol use and burden for 195 countries and territories, 1990\u20132016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet, 392, 1015\u20131035."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Ivanova, D., and Giannouli, V. (2024, March 07). Lesch Type III Alcoholism in Bulgarian Women: Impli Cations and Recommendations for Psychotherapy. Available online: https:\/\/www.internationaljournalofcaringsciences.org\/docs\/51_ivanova_original_10_3.pdf.","DOI":"10.33920\/pro-01-2404-09"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Marquez-Arrico, J.E., Navarro, J.F., and Adan, A. (2020). Health-Related Quality of Life in Male Patients under Treatment for Substance Use Disorders with and without Major Depressive Disorder: Influence in Clinical Course at One-Year Follow-Up. J. Clin. Med., 9.","DOI":"10.3390\/jcm9103110"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1037\/per0000563","article-title":"The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, alternative model conceptualization of borderline personality disorder: A review of the evidence","volume":"13","author":"Vanwoerden","year":"2022","journal-title":"Personal. Disord."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Wong, F.Y., Yang, L., Yuen, J.W.M., Chang, K.K.P., and Wong, F.K.Y. (2018). Assessing quality of life using WHOQOL-BREF: A cross-sectional study on the association between quality of life and neighborhood environmental satisfaction, and the mediating effect of health-related behaviors. BMC Public Health, 18.","DOI":"10.1186\/s12889-018-5942-3"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1007\/s11136-020-02463-z","article-title":"The WHOQOL-BREF: A modern psychometric evaluation of its internal construct validity in people with multiple sclerosis","volume":"29","author":"Pomeroy","year":"2020","journal-title":"Qual. Life Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4265","DOI":"10.2147\/JMDH.S440764","article-title":"Evaluating the Aspects of Quality of Life in Individuals with Substance Use Disorder: A Systematic Review Based on the WHOQOL Questionnaire","volume":"16","author":"Bratu","year":"2023","journal-title":"J. Multidiscip. Healthc."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"108122","DOI":"10.1016\/j.jsat.2020.108122","article-title":"Inside Alcohol Behavioral Couple Therapy (ABCT): In-session speech trajectories and drinking outcomes","volume":"118","author":"Fokas","year":"2020","journal-title":"J. Subst. Abuse Treat."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/famp.12231","article-title":"Alcohol-Focused Behavioral Couple Therapy","volume":"55","author":"McCrady","year":"2016","journal-title":"Fam. Process."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3390\/psychiatryint5010008","article-title":"Quality of Life in Alcohol Use Disorder: Exploration of Predictive Factors in a Cross-Sectional Study","volume":"5","author":"Dayal","year":"2024","journal-title":"Psychiatry Int."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"196","DOI":"10.4103\/jehp.jehp_248_23","article-title":"Quality of life in patients with alcohol use disorders admitted to de-addiction centers using WHOQOL-BREF scale-A cross-sectional study","volume":"12","author":"Colaco","year":"2023","journal-title":"J. Educ. Health Promot."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"262","DOI":"10.4103\/ipj.ipj_47_19","article-title":"Quality of life and disability in males with alcohol dependence syndrome","volume":"28","author":"Patkar","year":"2019","journal-title":"Ind. Psychiatry J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"40","DOI":"10.4103\/0253-7176.198941","article-title":"A Cross-sectional Study to Assess Disability and Its Correlates among Treatment Seeking Individuals with Alcohol Use Disorders","volume":"39","author":"Balhara","year":"2017","journal-title":"Indian J. Psychol. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s11136-004-5327-1","article-title":"Psychometric properties of the World Health Organization quality of life instrument (WHOQoL-BREF) in alcoholic males: A pilot study","volume":"14","author":"Fleck","year":"2005","journal-title":"Qual. Life Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.jsps.2020.06.014","article-title":"Assessing quality of life using WHOQOL-BREF: A cross-sectional insight among patients on warfarin in Malaysia","volume":"28","author":"Iqbal","year":"2020","journal-title":"Saudi Pharm. J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s11136-023-03522-x","article-title":"Alcohol consumption and health-related quality of life in regional, rural and metropolitan Australia: Analysis of cross-sectional data from the Community Health and Rural\/Regional Medicine (CHARM) study","volume":"33","author":"Redwood","year":"2024","journal-title":"Qual. Life Res."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Bara\u0144ski, K., Szemik, S., Kaleta-Pilarska, A., and Kowalska, M. (2023). General health and its relation to the quality of life and alcohol consumption in a Polish cohort of medical students\u2014Preliminary results of POLLEK survey. Front. Public Health, 11.","DOI":"10.3389\/fpubh.2023.1178124"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Hashemzadeh, I., Navarro, J.F., and Adan, A. (2023). Circadian functioning and quality of life in substance use disorder patients with and without comorbid schizophrenia. Prog. Neuropsychopharmacol. Biol. Psychiatry, 120.","DOI":"10.1016\/j.pnpbp.2022.110623"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Hashemzadeh, I., Marquez-Arrico, J.E., Hashemzadeh, K., Navarro, J.F., and Adan, A. (2021). Circadian Functioning and Quality of Life in Substance Use Disorder Patients with and without Comorbid Major Depressive Disorder. Front. Psychiatry, 12.","DOI":"10.3389\/fpsyt.2021.750500"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1177\/1039856217715999","article-title":"Violence in severe mental illness: Is cognition missing in the associations with ethnicity, cannabis and alcohol?","volume":"25","author":"Giannouli","year":"2017","journal-title":"Australas. Psychiatry"}],"container-title":["Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-9721\/12\/7\/158\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:17:37Z","timestamp":1760109457000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-9721\/12\/7\/158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,16]]},"references-count":37,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["diseases12070158"],"URL":"https:\/\/doi.org\/10.3390\/diseases12070158","relation":{},"ISSN":["2079-9721"],"issn-type":[{"value":"2079-9721","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,16]]}}}