{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:42:08Z","timestamp":1791996128080,"version":"4.4.0"},"reference-count":67,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>Hydatidiform moles, including both complete and partial moles, constitute a subset of gestational trophoblastic diseases characterized by abnormal fertilization resulting in villous hydrops and trophoblastic hyperplasia with or without embryonic development. This involves chromosomal abnormalities, where one or two sperms fertilize an empty oocyte (complete hydatidiform mole (CHM); mostly 46,XX) or two sperms fertilize one oocyte (partial hydatidiform mole (PHM); mostly 69,XXY). Notably, recurrent occurrences are associated with abnormal genomic imprinting of maternal effect genes such as NLRP7 (chromosome 19q13.4) and KHDC3L (chromosome 6q1). Ongoing efforts to enhance identification methods have led to the identification of growth-specific markers, including p57 (cyclin-dependent kinase inhibitor 1C; CDKN1C), which shows intact nuclear expression in the villous cytotrophoblast and villous stromal cells in PHMs and loss of expression in CHMs. Treatment of hydatidiform moles includes dilation and curettage for uterine evacuation of the molar pregnancy followed by surveillance of human chorionic gonadotropin (HCG) levels to confirm disease resolution and rule out the development of any gestational trophoblastic neoplasia. In this review, we provide a synopsis of the existing literature on hydatidiform moles, their diagnosis, histopathologic features, and management.<\/jats:p>","DOI":"10.3390\/diseases12070159","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T08:48:29Z","timestamp":1721206109000},"page":"159","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Gestational Trophoblastic Disease: Complete versus Partial Hydatidiform Moles"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3327-1988","authenticated-orcid":false,"given":"Jeffrey","family":"Gonzalez","sequence":"first","affiliation":[{"name":"Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0201-6420","authenticated-orcid":false,"given":"Meagan","family":"Popp","sequence":"additional","affiliation":[{"name":"Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Ocejo","sequence":"additional","affiliation":[{"name":"Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1509-3855","authenticated-orcid":false,"given":"Alvaro","family":"Abreu","sequence":"additional","affiliation":[{"name":"Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3799-2595","authenticated-orcid":false,"given":"Hisham F.","family":"Bahmad","sequence":"additional","affiliation":[{"name":"The Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Poppiti","sequence":"additional","affiliation":[{"name":"The Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL 33140, USA"},{"name":"Department of Pathology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL 33199, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1080\/19336918.2015.1093275","article-title":"The hydatidiform mole","volume":"10","author":"Candelier","year":"2015","journal-title":"Cell Adhes. Migr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1146\/annurev-pathol-052016-100237","article-title":"Hydatidiform Moles: Genetic Basis and Precision Diagnosis","volume":"12","author":"Hui","year":"2017","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1093\/oxfordjournals.aje.a114018","article-title":"Risk Factors for Gestational Trophoblastic Disease in Italy","volume":"121","author":"Vecchia","year":"1985","journal-title":"Am. J. Epidemiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.placenta.2017.12.008","article-title":"New insights in the pathophysiology of complete hydatidiform mole","volume":"62","author":"Jauniaux","year":"2018","journal-title":"Placenta"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.jmoldx.2011.02.002","article-title":"Diagnosis of Hydatidiform Moles by Polymorphic Deletion Probe Fluorescence in Situ Hybridization","volume":"13","author":"Chiang","year":"2011","journal-title":"J. Mol. Diagn."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/modpathol.2013.143","article-title":"Characteristics of hydatidiform moles: Analysis of a prospective series with p57 immunohistochemistry and molecular genotyping","volume":"27","author":"Banet","year":"2014","journal-title":"Mod. Pathol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00428-020-02802-y","article-title":"Germline NLRP7 mutations: Genomic imprinting and hydatidiform mole","volume":"477","author":"Hui","year":"2020","journal-title":"Virchows Arch."},{"key":"ref_8","first-page":"522","article-title":"Comparison of p57, c-erbB-2, CD117, and Bcl-2 expression in the differential diagnosis of hydatidiform mole and hydropic abortion","volume":"37","author":"Erol","year":"2016","journal-title":"Eur. J. Gynaecol. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/ijgo.13877","article-title":"Diagnosis and management of gestational trophoblastic disease: 2021 update","volume":"155","author":"Ngan","year":"2021","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1093\/ajcp\/aqaa163","article-title":"Robbins and Cotran Pathologic Basis of Disease","volume":"154","author":"Hoda","year":"2020","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1093\/humrep\/dev027","article-title":"Trophoblast subtype-specific EGFR\/ERBB4 expression correlates with cell cycle progression and hyperplasia in complete hydatidiform moles","volume":"30","author":"Fock","year":"2015","journal-title":"Hum. Reprod."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.placenta.2016.12.009","article-title":"Genomic profile in gestational and non-gestational choriocarcinomas","volume":"50","author":"Mello","year":"2017","journal-title":"Placenta"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.ygyno.2017.12.008","article-title":"What is the optimal duration of human chorionic gonadotrophin surveillance following evacuation of a molar pregnancy? A retrospective analysis on over 20,000 consecutive patients","volume":"148","author":"Coyle","year":"2018","journal-title":"Gynecol. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"430","DOI":"10.2478\/raon-2022-0038","article-title":"Advances in diagnostics and management of gestational trophoblastic disease","volume":"56","author":"Lukinovic","year":"2022","journal-title":"Radiol. Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1038\/bjc.2011.139","article-title":"Hyperthyroidism and human chorionic gonadotrophin production in gestational trophoblastic disease","volume":"104","author":"Walkington","year":"2011","journal-title":"Br. J. Cancer"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Savage, P., Monk, D., Hernandez Mora, J.R., van der Westhuizen, N., Rauw, J., Tinker, A., Robinson, W., Song, Q., Seckl, M.J., and Fisher, R.A. (2019). A case of intraplacental gestational choriocarcinoma; characterised by the methylation pattern of the early placenta and an absence of driver mutations. BMC Cancer, 19.","DOI":"10.1186\/s12885-019-5906-8"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"S123","DOI":"10.1016\/j.ijgo.2015.06.008","article-title":"Update on the diagnosis and management of gestational trophoblastic disease","volume":"131","author":"Ngan","year":"2015","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1093\/humrep\/deq052","article-title":"The risk of post-molar gestational trophoblastic neoplasia is higher in heterozygous than in homozygous complete hydatidiform moles","volume":"25","author":"Baasanjav","year":"2010","journal-title":"Hum. Reprod."},{"key":"ref_19","first-page":"291","article-title":"Determination of Clinical Process and Response Rate to Treatment in Patients with Gestational Trophoblastic Neoplasia (GTN) with Low and High Risk and Evaluation of Their First Pregnancy Outcome","volume":"12","author":"Aznab","year":"2018","journal-title":"Int. J. Hematol. Oncol. Stem. Cell Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"s110","DOI":"10.1017\/S1751731118000526","article-title":"Review: The epic journey of sperm through the female reproductive tract","volume":"12","author":"Miller","year":"2018","journal-title":"Animal"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-60327-009-0_1","article-title":"Human Embryogenesis: Overview","volume":"550","author":"Vaillancourt","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"ref_22","unstructured":"Betts, J.G., DeSaix, P., Johnson, J.E., Korol, O., Kruse, D.H., Poe, B., Wise, J.A., Womble, M., and Young, K.A. (2013). Anatomy and Physiology, Openstax."},{"key":"ref_23","unstructured":"Khan, Y.S., and Ackerman, K.M. (2023). Embryology, Week 1. StatPearls, StatPearls Publishing."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e6490","DOI":"10.7717\/peerj.6490","article-title":"Incidence of gestational trophoblastic disease in South Korea: A longitudinal, population-based study","volume":"7","author":"Yuk","year":"2019","journal-title":"PeerJ"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0140-6736(10)60280-2","article-title":"Gestational Trophoblastic Disease","volume":"376","author":"Seckl","year":"2010","journal-title":"Lancet"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/AOG.0000000000004240","article-title":"Gestational Trophoblastic Disease","volume":"137","author":"Soper","year":"2021","journal-title":"Obstet. Gynecol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"28","DOI":"10.5306\/wjco.v10.i2.28","article-title":"Challenges in the diagnosis and treatment of gestational trophoblastic neoplasia worldwide","volume":"10","author":"Braga","year":"2019","journal-title":"World J. Clin. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S0025-6196(12)60805-2","article-title":"A Genetic Review of Complete and Partial Hydatidiform Moles and Nonmolar Triploidy","volume":"67","author":"Lindor","year":"1992","journal-title":"Mayo Clin. Proc."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tjog.2017.12.001","article-title":"Clinical and genetic-epignetic aspects of recurrent hydatidiform mole: A review of literature","volume":"57","author":"Fallahi","year":"2018","journal-title":"Taiwan J. Obstet. Gynecol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1007\/s10815-022-02592-z","article-title":"Genetic screening of Chinese patients with hydatidiform mole by whole-exome sequencing and comprehensive analysis","volume":"39","author":"Yang","year":"2022","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/0002-9378(78)90792-5","article-title":"The syndromes of hydatidiform mole","volume":"132","author":"Szulman","year":"1978","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1097\/00001703-199302000-00015","article-title":"Current approaches to diagnosis and treatment of gestational trophoblastic disease","volume":"5","author":"Smith","year":"1993","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/15513810903266138","article-title":"Histopathological diagnosis of hydatidiform mole: Contemporary features and clinical implications","volume":"29","author":"Sebire","year":"2010","journal-title":"Fetal Pediatr. Pathol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1515\/bjmg-2017-0009","article-title":"Molecular and immunohistochemical characteristics of complete hydatidiform moles","volume":"20","author":"Prodanova","year":"2017","journal-title":"Balk. J. Med. Genet."},{"key":"ref_35","first-page":"269","article-title":"Differential expression of p57kip2, a maternally imprinted cdk inhibitor, in normal human placenta and gestational trophoblastic disease","volume":"78","author":"Chilosi","year":"1998","journal-title":"Lab. Investig. A J. Technol. Methods Pathol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1097\/PAS.0b013e318191f309","article-title":"Diagnosis and Subclassification of Hydatidiform Moles Using p57 Immunohistochemistry and Molecular Genotyping: Validation and Prospective Analysis in Routine and Consultation Practice Settings with Development of an Algorithmic Approach","volume":"33","author":"McConnell","year":"2009","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1053\/j.semdp.2014.03.004","article-title":"Immunohistochemistry and other ancillary techniques in the diagnosis of gestational trophoblastic diseases","volume":"31","author":"Buza","year":"2014","journal-title":"Semin. Diagn. Pathol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.prp.2011.06.004","article-title":"The usefulness of p57KIP2 immunohistochemical staining and genotyping test in the diagnosis of the hydatidiform mole","volume":"207","author":"Landolsi","year":"2011","journal-title":"Pathol. Res. Pr."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"133","DOI":"10.4103\/ijmr.IJMR_982_15","article-title":"Utility of p57 immunohistochemistry in differentiating between complete mole, partial mole & non-molar or hydropic abortus","volume":"145","author":"Kar","year":"2017","journal-title":"Indian J. Med. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/PAS.0000000000001749","article-title":"Loss of p57 Expression in Conceptions Other Than Complete Hydatidiform Mole","volume":"46","author":"Xing","year":"2021","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/PGP.0b013e3182630d8c","article-title":"Characterization of androgenetic\/biparental mosaic\/chimeric conceptions, including those with a molar component: Morphology, p57 immnohistochemistry, molecular genotyping, and risk of persistent gestational trophoblastic disease","volume":"32","author":"Lewis","year":"2013","journal-title":"Int. J. Gynecol. Pathol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/ajcp\/aqy012","article-title":"Diagnostic Utility of Twist1, Ki-67, and E-Cadherin in Diagnosing Molar Gestations and Hydropic Abortions","volume":"149","author":"Moussa","year":"2018","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.ygyno.2008.09.005","article-title":"Current management of gestational trophoblastic diseases","volume":"112","author":"Berkowitz","year":"2009","journal-title":"Gynecol. Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1097\/PAS.0b013e31825ea736","article-title":"Diagnostic reproducibility of hydatidiform moles: Ancillary techniques (p57 immunohistochemistry and molecular genotyping) improve morphologic diagnosis for both recently trained and experienced gynecologic pathologists","volume":"36","author":"Gupta","year":"2012","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1111\/apm.12187","article-title":"A survey of zeb1, twist and claudin 1 and 4 expression during placental development and disease","volume":"122","author":"Pirinen","year":"2014","journal-title":"APMIS Acta Pathol. Microbiol. Immunol. Scand."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.placenta.2010.06.017","article-title":"Cadherins in the human placenta\u2014Epithelial\u2013mesenchymal transition (EMT) and placental development","volume":"31","author":"Kokkinos","year":"2010","journal-title":"Placenta"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13000-023-01329-5","article-title":"Pathogenic role of Twist-1 protein in hydatidiform molar pregnancies and investigation of its potential diagnostic utility in complete moles","volume":"18","author":"Jahanbin","year":"2023","journal-title":"Diagn. Pathol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-9","article-title":"The Ki-67 protein: From the known and the unknown","volume":"182","author":"Scholzen","year":"2000","journal-title":"J. Cell. Physiol."},{"key":"ref_49","first-page":"1105","article-title":"Is Ki-67 of Diagnostic Value in Distinguishing Between Partial and Complete Hydatidiform Moles? A Systematic Review and Meta-analysis","volume":"38","author":"Zhao","year":"2018","journal-title":"Anticancer Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"590","DOI":"10.5812\/ircmj.5348","article-title":"Ki-67 Expression in Hydatidiform Moles and Hydropic Abortions","volume":"15","author":"Khooei","year":"2013","journal-title":"Iran. Red Crescent Med. J."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s12253-015-0031-8","article-title":"Immunohistochemical Analysis of E-Cadherin, p53 and Inhibin-\u03b1 Expression in Hydatidiform Mole and Hydropic Abortion","volume":"22","author":"Erol","year":"2016","journal-title":"Pathol. Oncol. Res. POR"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Ozaki, T., and Nakagawara, A. (2011). p53: The attractive tumor suppressor in the cancer research field. J. Biomed. Biotechnol., 2011.","DOI":"10.1155\/2011\/603925"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.prp.2018.12.015","article-title":"Immunohistochemical analysis of c-erbB-2, Bcl-2, p53, p21WAF1\/Cip1, p63 and Ki-67 expression in hydatidiform moles","volume":"215","author":"Nabiha","year":"2019","journal-title":"Pathol. Res. Pract."},{"key":"ref_54","first-page":"694","article-title":"Immunohistochemistry of p57 and p53 protein in differential diagnosis of hydropic abortion, partial and complete hydatidiform mole","volume":"40","author":"Chen","year":"2011","journal-title":"Zhonghua Bing Li Xue Za Zhi Chin. J. Pathol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s11515-017-1462-2","article-title":"Analysis of p53 expression in partial hydatidiform mole and hydropic abortion","volume":"12","author":"Kheradmand","year":"2017","journal-title":"Front. Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.1101\/gad.1463206","article-title":"p63 regulates proliferation and differentiation of developmentally mature keratinocytes","volume":"20","author":"Truong","year":"2006","journal-title":"Genes Dev."},{"key":"ref_57","first-page":"462","article-title":"Diagnostic value of P63 in differentiating normal gestation from molar pregnancy","volume":"18","author":"Heidarpour","year":"2013","journal-title":"J. Res. Med. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.placenta.2005.05.006","article-title":"P63 Expression in Hydropic Abortion and Gestational Trophoblastic Diseases","volume":"27","author":"Ramalho","year":"2006","journal-title":"Placenta"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nrm2308","article-title":"The BCL-2 protein family: Opposing activities that mediate cell death","volume":"9","author":"Youle","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_60","first-page":"148","article-title":"Immunohistochemical expression of BCL-2 in hydatidiform moles: A tissue microarray study","volume":"1","author":"Arafa","year":"2023","journal-title":"Pathologica"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1111\/ajo.13130","article-title":"Pre-operative classification of molar pregnancy: How good is ultrasound?","volume":"60","author":"Stamatopoulos","year":"2020","journal-title":"Aust. N. Z. J. Obstet. Gynaecol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.radi.2022.06.005","article-title":"The diagnostic value and accuracy of ultrasound in diagnosing hydatidiform mole: A systematic review and meta-analysis of the literature","volume":"28","author":"Newhouse","year":"2022","journal-title":"Radiography"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/jcu.22410","article-title":"Sonographic diagnosis of partial versus complete molar pregnancy: A reappraisal","volume":"45","author":"Savage","year":"2016","journal-title":"J. Clin. Ultrasound"},{"key":"ref_64","first-page":"181","article-title":"Molecular genetic studies of complete hydatidiform moles","volume":"4","author":"Carey","year":"2015","journal-title":"Transl Pediatr"},{"key":"ref_65","first-page":"e10319","article-title":"Hydatidiform Mole in a Patient with a Concern for Neoplasia: A Case Report","volume":"12","author":"Prabhu","year":"2020","journal-title":"Cureus"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"548","DOI":"10.5468\/ogs.2016.59.6.548","article-title":"Giant invasive mole presenting as a cause of abdominopelvic mass in a perimenopausal woman: An unusual presentation of a rare pathology","volume":"59","author":"Akyol","year":"2016","journal-title":"Obstet. Gynecol. Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1136\/ijgc-2020-001784","article-title":"Fertility and pregnancy outcome in gestational trophoblastic disease","volume":"31","author":"Joneborg","year":"2021","journal-title":"Int. J. Gynecol. Cancer"}],"container-title":["Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-9721\/12\/7\/159\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:18:02Z","timestamp":1760109482000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-9721\/12\/7\/159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,17]]},"references-count":67,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["diseases12070159"],"URL":"https:\/\/doi.org\/10.3390\/diseases12070159","relation":{},"ISSN":["2079-9721"],"issn-type":[{"value":"2079-9721","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,17]]}}}