{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:30:22Z","timestamp":1760146222706,"version":"build-2065373602"},"reference-count":33,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T00:00:00Z","timestamp":1727827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>Background. Incidentalomas have an increasing incidence all over the world due to a larger access to imaging assessments, and endocrine incidentalomas make no exception in this matter, including pituitary incidentalomas (PIs). Objective. Our objective was to analyse the dynamic changes amid a second computed tomography (CT) scan after adult patients were initially confirmed with a PI (non-functioning micro-adenoma). Methods. This was a multi-centric, longitudinal, retrospective study in adults (aged between 20 and 70 y) amid real-world data collection. We excluded patients who experienced baseline pituitary hormonal excess or deficiency or those with tumours larger than 1 cm. Results. A total of 117 adults were included (94.02% females) with a mean age of 43.86 \u00b1 11.99 years, followed between 6 and 156 months with a median (M) of 40 months (Q1 Q3: 13.50, 72.00). At the time of PI diagnosis, the transverse diameter had a mean value of 0.53 \u00b1 0.16 cm, the longitudinal mean diameter was 0.41 \u00b1 0.13 cm, and the largest diameter was 0.55 \u00b1 0.16 cm. No PI became functioning during follow-up, neither associated hypopituitarism nor increased &gt;1 cm diameter. A total of 46\/117 (39.32%) patients had a larger diameter during follow-up (increase group = IG) versus a non-increase group (non-IG; N = 71, 60.68%) that included the subjects with stationary or decreased diameters. IG had lower initial transverse, longitudinal, and largest diameter versus non-IG: 0.45 \u00b1 0.12 versus 0.57 \u00b1 0.17 (p &lt; 0.0001), 0.36 \u00b1 0.11 versus 0.43 \u00b1 0.13 (p = 0.004), respectively, 0.46 \u00b1 0.12 versus 0.6 \u00b1 0.16 (p &lt; 0.0001). IG versus non-IG had a larger period of surveillance: M (Q1, Q3) of 48 (24, 84) versus 32.5 (12, 72) months (p = 0.045) and showed similar age, pituitary hormone profile, and tumour lateralisation at baseline and displayed a median diameter change of +0.14 cm versus \u22120.03 cm (p &lt; 0.0001). To conclude, a rather high percent of patients might experience PI diameter increase during a longer period of follow-up, including those with a smaller initial size, while the age at diagnosis does not predict the tumour growth. This might help practitioners with further long-term surveillance protocols.<\/jats:p>","DOI":"10.3390\/diseases12100240","type":"journal-article","created":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T11:29:24Z","timestamp":1727868564000},"page":"240","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Real-World Longitudinal Study in Non-Functioning Pituitary Incidentalomas: A PRECES Micro-Adenomas Sub-Analysis"],"prefix":"10.3390","volume":"12","author":[{"given":"Mihai","family":"Costachescu","sequence":"first","affiliation":[{"name":"Department of Radiology and Medical Imaging, Fundeni Clinical Institute, 022328 Bucharest, Romania"},{"name":"PhD Doctoral School, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 010825 Bucharest, Romania"},{"name":"Thoracic Surgery Department, \u201cDr. Carol Davila\u201d Central Emergency University Military Hospital, 010825 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2274-5666","authenticated-orcid":false,"given":"Claudiu","family":"Nistor","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Department, \u201cDr. Carol Davila\u201d Central Emergency University Military Hospital, 010825 Bucharest, Romania"},{"name":"Department 4\u2014Cardio-Thoracic Pathology, Thoracic Surgery II Discipline, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 0505474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Valea","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"},{"name":"Department of Endocrinology, County Emergency Clinical Hospital, 400347 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oana-Claudia","family":"Sima","sequence":"additional","affiliation":[{"name":"PhD Doctoral School, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 010825 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Ciuche","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Department, \u201cDr. Carol Davila\u201d Central Emergency University Military Hospital, 010825 Bucharest, Romania"},{"name":"Department 4\u2014Cardio-Thoracic Pathology, Thoracic Surgery II Discipline, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 0505474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihaela","family":"Stanciu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, \u201cLucian Blaga\u201d University of Sibiu, Victoriei Blvd., 550024 Sibiu, Romania"},{"name":"Department of Endocrinology, Clinical County Emergency Hospital, 550245 Sibiu, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8585-3835","authenticated-orcid":false,"given":"Mara","family":"Carsote","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Clinical Endocrinology V, C.I. Parhon National Institute of Endocrinology, 011863 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4402-7194","authenticated-orcid":false,"given":"Mihai-Lucian","family":"Ciobica","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Gastroenterology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Department of Internal Medicine I and Rheumatology, \u201cDr. Carol Davila\u201d Central Military University Emergency Hospital, 010825 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/ejendo\/lvad070","article-title":"Natural history of non-functioning pituitary microadenomas: Results from the UK non-functioning pituitary adenoma consortium","volume":"189","author":"Hamblin","year":"2023","journal-title":"Eur. J. Endocrinol."},{"key":"ref_2","first-page":"25","article-title":"Contrast-enhanced ultrasound-clinical applications","volume":"114","author":"Anghel","year":"2011","journal-title":"Rom. J. Mil. Med."},{"key":"ref_3","first-page":"9","article-title":"The role of contrast-enhanced ultrasound in risk assessment of carotid atheroma","volume":"119","author":"Stanciu","year":"2016","journal-title":"Rom. J. Mil. Med."},{"key":"ref_4","first-page":"370","article-title":"Emergency surgical tracheal decompression in a huge retrosternal goiter","volume":"13","author":"Nistor","year":"2017","journal-title":"Acta Endocrinol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/s00432-024-05891-3","article-title":"Nuclear medicine imaging modalities to detect incidentalomas and their impact on patient management: A systematic review","volume":"150","author":"Costanzo","year":"2024","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_6","first-page":"672","article-title":"Clinically active pituitary tumors","volume":"65","author":"Unger","year":"2024","journal-title":"Inn. Med."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Nistor, C.E., G\u0103van, C.S., Ciritel, A.A., Nemes, A.F., and Ciuche, A. (2022). The Association of Minimally Invasive Surgical Approaches and Mortality in Patients with Malignant Pleuropericarditis-A 10 Year Retrospective Observational Study. Medicina, 58.","DOI":"10.3390\/medicina58060718"},{"key":"ref_8","first-page":"476","article-title":"Metastases in daily endocrine practice","volume":"51","author":"Carsote","year":"2016","journal-title":"Arch. Balk. Med. Union"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Nistor, C.E., Ciuche, A., Cucu, A.P., Serban, B., Cursaru, A., Cretu, B., and Cirstoiu, C. (2022). Clavicular Malignancies: A Borderline Surgical Management. Medicina, 58.","DOI":"10.3390\/medicina58070910"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s10140-023-02138-5","article-title":"Expecting the unexpected: Incidental findings at a level 1 trauma center","volume":"30","author":"Kolbeinsson","year":"2023","journal-title":"Emerg. Radiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"36","DOI":"10.53738\/REVMED.2024.20.856-7.36","article-title":"Endocrinology: What\u2019s new in 2023","volume":"20","author":"Ameti","year":"2024","journal-title":"Rev. Medicale Suisse"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.eprac.2022.10.004","article-title":"Pituitary Incidentalomas: Best Practices and Looking Ahead","volume":"29","author":"Giraldi","year":"2023","journal-title":"Endocr. Pract."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Tahara, S., Hattori, Y., Suzuki, K., Ishisaka, E., Teramoto, S., and Morita, A. (2022). An Overview of Pituitary Incidentalomas: Diagnosis, Clinical Features, and Management. Cancers, 14.","DOI":"10.3390\/cancers14174324"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.mcna.2021.05.015","article-title":"What to Do with Incidentally Discovered Pituitary Abnormalities?","volume":"105","author":"Langlois","year":"2021","journal-title":"Med. Clin. N. Am."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1507\/endocrj.EJ20-0335","article-title":"A survey of surgically resected pituitary incidentalomas and a comparison of the clinical features and surgical outcomes of non-functioning pituitary adenomas discovered incidentally versus symptomatically","volume":"68","author":"Ono","year":"2021","journal-title":"Endocr. J."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Kageyama, K., and Nishiyama, M. (2023). Pituitary Tumors: Molecular Insights, Diagnosis, and Targeted Therapy. Cancers, 15.","DOI":"10.3390\/cancers15235526"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"104081","DOI":"10.1016\/j.lpm.2021.104081","article-title":"Pituitary incidentaloma","volume":"50","author":"Constantinescu","year":"2021","journal-title":"Presse Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"R171","DOI":"10.1530\/EJE-15-1272","article-title":"Management of endocrine disease: Pituitary \u2018incidentaloma\u2019: Neuroradiological assessment and differential diagnosis","volume":"175","author":"Vasilev","year":"2016","journal-title":"Eur. J. Endocrinol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1530\/eje.0.1490123","article-title":"A survey of pituitary incidentaloma in Japan","volume":"149","author":"Sanno","year":"2003","journal-title":"Eur. J. Endocrinol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1038\/s41433-024-03187-x","article-title":"Neuro-ophthalmic evaluation and management of pituitary disease","volume":"38","author":"Wang","year":"2024","journal-title":"Eye"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1001\/archinte.1995.00430020067008","article-title":"The natural history of the pituitary incidentaloma","volume":"155","author":"Donovan","year":"1995","journal-title":"Arch. Intern. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"129","DOI":"10.7861\/clinmed.2023-0020","article-title":"Management of pituitary incidentalomas","volume":"23","author":"Westall","year":"2023","journal-title":"Clin. Med"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s11102-022-01290-4","article-title":"UK practice on incidentally detected non-functioning pituitary microadenomas: Analysis of two national surveys during a 12-year interval","volume":"26","author":"Hamblin","year":"2023","journal-title":"Pituitary"},{"key":"ref_24","first-page":"946","article-title":"Clinical aspects of pituitary incidentalomas","volume":"62","author":"Sanno","year":"2004","journal-title":"Nihon Rinsho"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1053\/j.sult.2004.10.001","article-title":"Management of pituitary incidentalomas: According to a survey of pituitary incidentalomas in Japan","volume":"Volume 26","author":"Oyama","year":"2005","journal-title":"Seminars in Ultrasound, CT and MRI"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1080\/00015458.2012.11680835","article-title":"Pituitary incidentaloma: To operate or not to operate?","volume":"112","author":"Donckier","year":"2012","journal-title":"Acta Chir. Belg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"40","DOI":"10.14791\/btrt.2023.0046","article-title":"Suggestion of Follow-Up Period in Nonfunctioning Pituitary Incidentaloma Based on MRI Characteristics","volume":"12","author":"Jung","year":"2024","journal-title":"Brain Tumor Res. Treat."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Baldo, F., Marin, M., Murru, F.M., Barbi, E., and Tornese, G. (2022). Dealing With Brain MRI Findings in Pediatric Patients With Endocrinological Conditions: Less Is More?. Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.780763"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e22713","DOI":"10.1097\/MD.0000000000022713","article-title":"Characteristics and clinical outcomes in pituitary incidentalomas and non-incidental pituitary tumors treated with endoscopic transsphenoidal surgery","volume":"99","author":"Morinaga","year":"2020","journal-title":"Medicine"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1007\/s11102-019-00940-4","article-title":"Pituitary incidentalomas in paediatric age are different from those described in adulthood","volume":"22","author":"Souteiro","year":"2019","journal-title":"Pituitary"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1007\/s11604-023-01407-0","article-title":"Imaging of pituitary tumors: An update with the 5th WHO Classifications-part 2. Neoplasms other than PitNET and tumor-mimicking lesions","volume":"41","author":"Tsukamoto","year":"2023","journal-title":"Jpn. J. Radiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2478\/bjmg-2023-0003","article-title":"The Predisposition for Type 2 Diabetes Mellitus and Metabolic Syndrome","volume":"26","author":"Berca","year":"2023","journal-title":"Balk. J. Med. Genet."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Gontarz-Nowak, K., Szklarz, M., Szychli\u0144ska, M., Matuszewski, W., and Bandurska-Stankiewicz, E. (2023). A Brief Look at Hashimoto\u2019s Disease, Adrenal Incidentalomas, Obesity and Insulin Resistance-Could Endocrine Disruptors Be the Other Side of the Same Coin?. Medicina, 59.","DOI":"10.3390\/medicina59071234"}],"container-title":["Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-9721\/12\/10\/240\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:09:33Z","timestamp":1760112573000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-9721\/12\/10\/240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,2]]},"references-count":33,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["diseases12100240"],"URL":"https:\/\/doi.org\/10.3390\/diseases12100240","relation":{},"ISSN":["2079-9721"],"issn-type":[{"type":"electronic","value":"2079-9721"}],"subject":[],"published":{"date-parts":[[2024,10,2]]}}}