{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:38:03Z","timestamp":1760146683796,"version":"build-2065373602"},"reference-count":30,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T00:00:00Z","timestamp":1732924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Victor Babes University of Medicine and Pharmacy Timisoara"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>Background: Pulmonary lobe resection is a common surgical intervention for various benign lung diseases, including tuberculosis (TB), bronchiectasis, and benign lung nodules. While immediate clinical outcomes are well documented, the impact on patients\u2019 quality of life (QoL) remains less explored. This study aims to evaluate QoL before and after pulmonary lobe resection over a 6-month period among patients with benign lung diseases. Objectives: To assess and compare changes in QoL among patients undergoing pulmonary lobe resection for TB, bronchiectasis, and benign lung nodules, and to identify factors influencing QoL outcomes. Methods: This prospective study included 84 patients who underwent pulmonary lobe resection for benign lung diseases, divided into three groups: TB (n = 22), bronchiectasis (n = 31), and benign lung nodules (n = 31). QoL was assessed using the SF-36 and WHOQOL-BREF questionnaires preoperatively and at 6 months postoperatively. Anxiety and depression were evaluated using the Hospital Anxiety and Depression Scale (HADS), and perceived stress was measured using the Perceived Stress Scale (PSS-10). Statistical analyses included paired t-tests, ANOVA, and Pearson\u2019s correlation, with p-values &lt; 0.05 considered significant. Results: At 6 months postoperatively, all groups showed significant improvements in physical and mental QoL scores (p &lt; 0.05). The TB group exhibited the greatest improvement in physical health domains, while the bronchiectasis group showed significant enhancement in social functioning. Anxiety and depression scores decreased significantly in all groups, with the TB group showing the most substantial reduction (p &lt; 0.01). Perceived stress levels also decreased across all groups. Comparisons revealed that the TB group had significantly higher QoL improvement compared to the other groups (p &lt; 0.05). Conclusions: Pulmonary lobe resection for benign diseases significantly improves QoL over a 6-month period, particularly in patients with TB. The findings suggest that surgical intervention not only alleviates physical symptoms but also enhances psychological well-being. These results underscore the importance of considering QoL outcomes in the management of benign lung diseases requiring surgical intervention.<\/jats:p>","DOI":"10.3390\/diseases12120307","type":"journal-article","created":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T09:00:10Z","timestamp":1733130010000},"page":"307","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quality of Life Evaluation Before and After Pulmonary Lobe Resection for Benign Diseases: A Comparative Study Among Patients with Tuberculosis, Bronchiectasis, and Benign Lung Nodules"],"prefix":"10.3390","volume":"12","author":[{"given":"Alin","family":"Nicola","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania"},{"name":"Doctoral School, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8302-8003","authenticated-orcid":false,"given":"Tamara Mirela","family":"Porosnicu","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5436-5158","authenticated-orcid":false,"given":"Sorina Maria Denisa","family":"Laitin","sequence":"additional","affiliation":[{"name":"Discipline of Epidemiology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2083-0581","authenticated-orcid":false,"given":"Cristian","family":"Oancea","sequence":"additional","affiliation":[{"name":"Center for Research and Innovation in Precision Medicine of Respiratory Diseases, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6667-3185","authenticated-orcid":false,"given":"Emanuela","family":"Tudorache","sequence":"additional","affiliation":[{"name":"Center for Research and Innovation in Precision Medicine of Respiratory Diseases, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,30]]},"reference":[{"key":"ref_1","first-page":"S138","article-title":"Quality of life after lung resection for lung cancer","volume":"7","author":"Pompili","year":"2015","journal-title":"J. Thorac. Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"220166","DOI":"10.1183\/20734735.0166-2022","article-title":"Tuberculosis: Current challenges and beyond","volume":"19","author":"Ghodousi","year":"2023","journal-title":"Breathe"},{"key":"ref_3","first-page":"186","article-title":"The medical and surgical treatment of drug-resistant tuberculosis","volume":"6","author":"Calligaro","year":"2014","journal-title":"J. Thorac. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e3511","DOI":"10.1097\/MD.0000000000003511","article-title":"The Role of Video-Assisted Thoracoscopic Therapeutic Resection for Medically Failed Pulmonary Tuberculosis","volume":"95","author":"Tseng","year":"2016","journal-title":"Medicine"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"411","DOI":"10.2147\/COPD.S6133","article-title":"The pathophysiology of bronchiectasis","volume":"4","author":"King","year":"2009","journal-title":"Int. J. Chronic Obstruct Pulm. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s12931-022-02023-8","article-title":"Increasing prevalence and burden of bronchiectasis in urban Chinese adults, 2013-2017: A nationwide population-based cohort study","volume":"23","author":"Feng","year":"2022","journal-title":"Respir. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"629","DOI":"10.5606\/tgkdc.dergisi.2020.19389","article-title":"Surgical treatment of bronchiectasis: Our 23 years of experience","volume":"28","author":"Acar","year":"2020","journal-title":"Turk. Gogus Kalp Damar Cerrahisi Derg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1159\/000526818","article-title":"Incidental Pulmonary Nodules\u2014What Do We Know in 2022","volume":"101","author":"Fink","year":"2022","journal-title":"Respiration"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"226","DOI":"10.4103\/atm.ATM_110_19","article-title":"Lung nodules: A comprehensive review on current approach and management","volume":"14","author":"Loverdos","year":"2019","journal-title":"Ann. Thorac. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1002\/pon.5990","article-title":"Psychological distress, understanding of cancer and illness uncertainty in patients with Cancer of Unknown Primary","volume":"31","author":"Wolyniec","year":"2022","journal-title":"Psychooncology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1097\/SLA.0000000000000854","article-title":"Infectious postoperative complications decrease long-term survival in patients undergoing curative surgery for colorectal cancer: A study of 12,075 patients","volume":"261","author":"Artinyan","year":"2015","journal-title":"Ann. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1111\/1759-7714.12782","article-title":"Survival rates after lobectomy versus sublobar resection for early-stage right middle lobe non-small cell lung cancer","volume":"9","author":"Lv","year":"2018","journal-title":"Thorac. Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1111\/1759-7714.14197","article-title":"Risk factors for surgical complications after anatomic lung resections in the era of VATS and ERAS","volume":"12","author":"Galata","year":"2021","journal-title":"Thorac. Cancer"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Nicola, A., Oancea, C., Barata, P.I., Adelina, M., Mateescu, T., Manolescu, D., Bratosin, F., Fericean, R.M., Pingilati, R.A., and Paleru, C. (2023). Health-Related Quality of Life and Stress-Related Disorders in Patients with Bronchiectasis after Pulmonary Resection. J. Pers. Med., 13.","DOI":"10.3390\/jpm13091310"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1186\/s12955-021-01892-9","article-title":"How different domains of quality of life are associated with latent dimensions of mental health measured by GHQ-12","volume":"19","author":"Nouri","year":"2021","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"855","DOI":"10.2165\/00019053-200119080-00007","article-title":"Quality of life and utility in patients with non-small cell lung cancer. Quality-of-life Study Group of the Master 2 Project in Pharmacoeconomics","volume":"19","author":"Trippoli","year":"2001","journal-title":"Pharmacoeconomics"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s11136-008-9326-5","article-title":"An empirical comparison of the WHOQOL-BREF and the SGRQ among patients with COPD","volume":"17","author":"Liang","year":"2008","journal-title":"Qual. Life Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1093\/icvts\/ivab030","article-title":"European Society of Thoracic Surgeons electronic quality of life application after lung resection: Field testing in a clinical setting","volume":"32","author":"Pompili","year":"2021","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"548","DOI":"10.33314\/jnhrc.v17i4.1042","article-title":"The Declaration of Helsinki on Medical Research involving Human Subjects: A Review of Seventh Revision","volume":"17","author":"Shrestha","year":"2020","journal-title":"J. Nepal Health Res. Counc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1744-859X-7-4","article-title":"Hospital Anxiety and Depression Scale (HADS): Validation in a Greek general hospital sample","volume":"7","author":"Michopoulos","year":"2008","journal-title":"Ann. Gen. Psychiatry"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e076372","DOI":"10.1136\/bmjopen-2023-076372","article-title":"Psychometric validation of the Perceived Stress Scale (PSS-10) among family caregivers of people with schizophrenia in China","volume":"13","author":"Xiao","year":"2023","journal-title":"BMJ Open"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ijid.2019.02.039","article-title":"Pulmonary function and respiratory health after successful treatment of drug-resistant tuberculosis","volume":"82","author":"Vashakidze","year":"2019","journal-title":"Int. J. Infect. Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1159\/000485382","article-title":"Current Indications and Outcome of Pulmonary Resections for Tuberculosis Complications in Ibadan, Nigeria","volume":"27","author":"Salami","year":"2018","journal-title":"Med. Princ. Pract."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Hasan, E.M., Calma, C.L., Tudor, A., Oancea, C., Tudorache, V., Petrache, I.A., Tudorache, E., and Papava, I. (2021). Coping, Anxiety, and Pain Intensity in Patients Requiring Thoracic Surgery. J. Pers. Med., 11.","DOI":"10.3390\/jpm11111221"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.athoracsur.2014.04.049","article-title":"Lung resection improves the quality of life of patients with symptomatic bronchiectasis","volume":"98","author":"Vallilo","year":"2014","journal-title":"Ann. Thorac. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"334","DOI":"10.21037\/atm.2019.06.62","article-title":"Quality of life in patients with bronchiectasis: A 2-year longitudinal study","volume":"7","author":"Magge","year":"2019","journal-title":"Ann. Transl. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.lungcan.2021.10.004","article-title":"Quality of life after VATS lung resection and SABR for early-stage non-small cell lung cancer: A longitudinal study","volume":"162","author":"Pompili","year":"2021","journal-title":"Lung Cancer"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"623","DOI":"10.5606\/tgkdc.dergisi.2020.19169","article-title":"Comparison of short-term quality of life in patients undergoing video-assisted thoracoscopic surgery versus thoracotomy","volume":"28","author":"Cansever","year":"2020","journal-title":"Turk. Gogus Kalp Damar Cerrahisi Derg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1016\/j.athoracsur.2020.05.080","article-title":"Health-Related Quality of Life After Lobectomy for Lung Cancer: Conceptual Framework and Measurement","volume":"110","author":"Brown","year":"2020","journal-title":"Ann. Thorac. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"6913","DOI":"10.21037\/jtd.2020.01.05","article-title":"Effect of operative approach on quality of life following anatomic lung cancer resection","volume":"12","author":"Singer","year":"2020","journal-title":"J. Thorac. Dis."}],"container-title":["Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-9721\/12\/12\/307\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:43:13Z","timestamp":1760114593000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-9721\/12\/12\/307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,30]]},"references-count":30,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["diseases12120307"],"URL":"https:\/\/doi.org\/10.3390\/diseases12120307","relation":{},"ISSN":["2079-9721"],"issn-type":[{"type":"electronic","value":"2079-9721"}],"subject":[],"published":{"date-parts":[[2024,11,30]]}}}