{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:21:18Z","timestamp":1784690478262,"version":"3.55.0"},"reference-count":61,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>Introduction: Consuming hypercaloric diets during pregnancy induces metabolic, immune, and maternal intestinal dysbiosis disorders. These conditions are transferred to the offspring through the placenta and breastfeeding, increasing susceptibility to metabolic diseases. We investigated the effect of L. rhamnosus GG supplementation on offspring maternally programmed with a hypercaloric diet. Methods: Our study involved sixteen female Wistar rats aged ten weeks, which were divided into four groups based on their diets: control (Ctrl), cafeteria (CAF), control + probiotic (PRO), and cafeteria + probiotic (CPRO). The control + probiotic and cafeteria + probiotic groups received a daily oral administration of 250 \u03bcL of L. rhamnosus GG cell suspension (equivalent to 109 UFC) for nine weeks. The body weight of the animals was recorded weekly, and their food intake was monitored every 24 h. An oral glucose tolerance test was conducted on the offspring at seven weeks of age. At the ninth week of age, animals were euthanized, and blood, tissues, and organs were collected. Results: Maternal supplementation with L. rhamnosus GG decreased food intake and the average birth weight, improved glucose sensitivity, and lowered the levels of LDL, cholesterol, triglycerides, and mesenteric adipose tissue in offspring compared with the control and cafeteria groups. Conclusions: Our findings indicate that supplementing with LGG during maternal programming could protect offspring from metabolic disruptions caused by a hypercaloric maternal diet.<\/jats:p>","DOI":"10.3390\/diseases12120312","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T09:18:32Z","timestamp":1733217512000},"page":"312","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Maternal Supplementation with Lacticaseibacillus rhamnosus GG Improves Glucose Tolerance and Modulates the Intestinal Microbiota of Offspring"],"prefix":"10.3390","volume":"12","author":[{"given":"Dayane","family":"Correia Gomes","sequence":"first","affiliation":[{"name":"Centro de Investigaciones Biom\u00e9dicas, Doctorado en Ciencias Biom\u00e9dicas, Universidad Veracruzana, Xalapa 91190, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Enrique","family":"Meza Alvarado","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Biom\u00e9dicas, Doctorado en Ciencias Biom\u00e9dicas, Universidad Veracruzana, Xalapa 91190, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus Alejandro","family":"Zamora Brise\u00f1o","sequence":"additional","affiliation":[{"name":"Advanced Molecular Studies Network, Campus III, Institute of Ecology A. C., Xalapa 91612, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9079-6748","authenticated-orcid":false,"given":"Cynthia","family":"Cano Sarmiento","sequence":"additional","affiliation":[{"name":"Food Research and Development Unit, Technological Institute of Veracruz, National Institute of Technology of Mexico, M.A. de Quevedo 2779, Veracruz 91897, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Camacho Morales","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Biochemistry and Molecular Medicine, Autonomous University of Nuevo Le\u00f3n, Monterrey 66455, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubi","family":"Viveros Contreras","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Biom\u00e9dicas, Doctorado en Ciencias Biom\u00e9dicas, Universidad Veracruzana, Xalapa 91190, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/s41582-021-00530-8","article-title":"Maternal immune activation and neuroinflammation in human neurodevelopmental disorders","volume":"17","author":"Han","year":"2021","journal-title":"Nat. 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