{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:38:47Z","timestamp":1760146727050,"version":"build-2065373602"},"reference-count":31,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>Noncardiogenic pulmonary edema after cardiac surgery is a rare but severe complication. The etiology remains poorly understood; however, the issue may arise from multiple sources. Possible causes include a significant inflammatory response or an autoimmune process. Pulmonary edema resulting from noncardiac etiologies can necessitate extracorporeal membrane oxygenation (ECMO) because most of the cases present a substantial volume of fluid expelled from the lungs and the medical team must manage the inability to achieve effective ventilation. A 64-year-old patient with known heart disease was admitted to our clinic with acute pulmonary edema. His medical history included Barlow\u2019s disease, severe mitral regurgitation (IIP2), moderate\u2013severe tricuspid regurgitation, and moderate pulmonary hypertension. The patient had a coronary angiography performed in a prior hospitalization before the surgical intervention which indicated the absence of coronary lesions. Preoperative screening (nasal, pharyngeal exudate, inguinal pouch culture, and urine culture) was negative, with no active dental infections. The patient was stabilized, and 14 days post-admission, mitral and tricuspid valve repair was performed via a thoracoscopic approach. After being admitted to intensive care post-surgery, the patient quickly developed pulmonary edema, producing a large volume (4.5 L) of yellow secretions through the intubation tube followed by hemodynamic instability necessitating high doses of medications to support circulation but no cardiorespiratory arrest. Due to his worsening condition, the patient was urgently taken back to the operating room, where veno-venous extracorporeal membrane oxygenation (VV-ECMO) was initiated to support oxygenation and stabilize the patient.<\/jats:p>","DOI":"10.3390\/diseases12120316","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T06:38:25Z","timestamp":1733294305000},"page":"316","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["ECMO in the Management of Noncardiogenic Pulmonary Edema with Increased Inflammatory Reaction After Cardiac Surgery: A Case Report and Literature Review"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0173-3617","authenticated-orcid":false,"given":"Raluca Elisabeta","family":"Staicu","sequence":"first","affiliation":[{"name":"Doctoral School Medicine-Pharmacy, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"},{"name":"Institute for Cardiovascular Diseases of Timisoara, Clinic of Anesthesia and Intensive Care, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Gheorghe Adam Street, No. 13A, 300310 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0600-1103","authenticated-orcid":false,"given":"Ana","family":"Lascu","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular Diseases of Timisoara, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Gheorghe Adam Street, No. 13A, 300310 Timisoara, Romania"},{"name":"Department III Functional Sciences\u2014Pathophysiology, \u201cVictor Babes\u201d University of Medicine and Pharmacy of Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"},{"name":"Centre for Translational Research and Systems Medicine, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petru","family":"Deutsch","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular Diseases of Timisoara, Clinic of Anesthesia and Intensive Care, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Gheorghe Adam Street, No. 13A, 300310 Timisoara, Romania"},{"name":"Department of Surgery X, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"},{"name":"Advanced Research Center of the Institute for Cardiovascular Diseases, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4870-8249","authenticated-orcid":false,"given":"Horea Bogdan","family":"Feier","sequence":"additional","affiliation":[{"name":"Department of Surgery X, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"},{"name":"Advanced Research Center of the Institute for Cardiovascular Diseases, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"},{"name":"Department VI Cardiology\u2014Cardiovascular Surgery, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aniko","family":"Mornos","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular Diseases of Timisoara, Clinic of Anesthesia and Intensive Care, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Gheorghe Adam Street, No. 13A, 300310 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Oprisan","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular Diseases of Timisoara, Clinic of Anesthesia and Intensive Care, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Gheorghe Adam Street, No. 13A, 300310 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavia","family":"Bijan","sequence":"additional","affiliation":[{"name":"Institute for Cardiovascular Diseases of Timisoara, Clinic of Anesthesia and Intensive Care, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Gheorghe Adam Street, No. 13A, 300310 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2412-1942","authenticated-orcid":false,"given":"Elena Cecilia","family":"Rosca","sequence":"additional","affiliation":[{"name":"Department of Neurology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"},{"name":"Clinical Emergency County Hospital Timisoara, 300736 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.36502\/2023\/ASJBCCR.6329","article-title":"Acute Pulmonary Edema Following Cardiopulmonary Bypass: A Case Report","volume":"7","author":"Wang","year":"2023","journal-title":"Asploro J. 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