{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:40:27Z","timestamp":1783464027166,"version":"3.55.0"},"reference-count":33,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>Background: Obstructive jaundice is a common health challenge in daily clinical practice caused by a heterogeneous group of benign and malignant conditions in or around extrahepatic bile ducts. This study aimed to investigate the causes of obstructive jaundice, analyze the age and sex distribution, and report the locations of obstruction. Methods: This was a retrospective study of electronic records of patients diagnosed with obstructive jaundice in the Hadhramout region in Yemen. Results: This study analyzed the data of 303 patients (mean age: 57 \u00b1 17.99 years; range: 18\u201395 years); 60.40% (n = 183) were female, and 39.60% (n = 120) were male. The highest prevalence was found in middle-aged adults (n = 112, 36.96%), followed by the old (n = 101, 33.33%). Common bile duct (CBD) stones were the most common cause of obstructive jaundice (n = 175, 57.8%), followed by CBD stricture (n = 58, 19.1%), carcinoma of the head of the pancreas (n = 35, 11.6%), cholangiocarcinoma (n = 21, 6.9%), and external compression of the CBD (n = 2, 0.7%). CBD stones, cholangiocarcinoma, and ampulla of Vater masses were more prevalent in females (30.9%, 3.8%, and 2.2%, respectively) than in males (25.8%, 2.9%, and 1.7%, respectively). In contrast, CBD stricture and carcinoma of the pancreas were more frequent in males, occurring in 12.1% and 7.1% of male patients, respectively, compared to 7.9% and 4.9% in female patients. The primary obstruction site was the CBD (n = 254, 83.8%), followed by the head of the pancreas (n = 30, 9.9%), and the ampulla of Vater (n = 13, 4.3%). Conclusions: Obstructive jaundice predominantly affects middle-aged adults followed by the old-aged patients predominantly in females. The most common cause of obstructive jaundice was CBD stones, followed by CBD stricture, while carcinoma of the head of the pancreas was the most common malignant cause, followed by cholangiocarcinoma. Distal CBD is the most common anatomical location of obstructive jaundice.<\/jats:p>","DOI":"10.3390\/diseases12120333","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T10:54:20Z","timestamp":1734605660000},"page":"333","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Demographic Profiles, Etiological Spectrum, and Anatomical Locations of the Post-Hepatic Obstructive Jaundice in Adult Population in Hadhramout Region in Yemen"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5049-6989","authenticated-orcid":false,"given":"Sultan Abdulwadoud","family":"Alshoabi","sequence":"first","affiliation":[{"name":"Department of Diagnostic Radiology, College of Applied Medical Sciences, Taibah University, Al-Madinah Al-Munawwarah 41477, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4621-2825","authenticated-orcid":false,"given":"Abdulkhaleq Ayedh","family":"Binnuhaid","sequence":"additional","affiliation":[{"name":"Department of Specialized Surgery, Radiology Section, Faculty of Medicine, Hadhramout University, Hadhramaut, Yemen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halah Fuad","family":"Muslem","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Dr. Suliman Al Habib Hospital Altakhasosi, Riyadh 12344, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6868-5294","authenticated-orcid":false,"given":"Abdullgabbar M.","family":"Hamid","sequence":"additional","affiliation":[{"name":"Radiology Department, Rush University Medical Center, Chicago, IL 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8196-3233","authenticated-orcid":false,"given":"Fahad H.","family":"Alhazmi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, College of Applied Medical Sciences, Taibah University, Al-Madinah Al-Munawwarah 41477, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal A.","family":"Alrehily","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, College of Applied Medical Sciences, Taibah University, Al-Madinah Al-Munawwarah 41477, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4816-4293","authenticated-orcid":false,"given":"Abdulaziz A.","family":"Qurashi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, College of Applied Medical Sciences, Taibah University, Al-Madinah Al-Munawwarah 41477, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamah M.","family":"Abdulaal","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, College of Applied Medical Sciences, Taibah University, Al-Madinah Al-Munawwarah 41477, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5039-8094","authenticated-orcid":false,"given":"Abdullah F.","family":"Alshamrani","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, College of Applied Medical Sciences, Taibah University, Al-Madinah Al-Munawwarah 41477, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6854-4624","authenticated-orcid":false,"given":"Awatif M.","family":"Omer","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, College of Applied Medical Sciences, Taibah University, Al-Madinah Al-Munawwarah 41477, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"ref_1","unstructured":"Joseph, A., and Samant, H. (2023). Jaundice. StatPearls, StatPearls Publishing."},{"key":"ref_2","first-page":"285","article-title":"Jaundice in infants and children: Causes, diagnosis, and management","volume":"24","author":"Chee","year":"2018","journal-title":"Hong Kong Med. J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1159\/000517301","article-title":"Jaundice as a Diagnostic and Therapeutic Problem: A General Practitioner\u2019s Approach","volume":"40","author":"Mijac","year":"2022","journal-title":"Dig. Dis."},{"key":"ref_4","unstructured":"Shah, R., and John, S. (2023). Cholestatic Jaundice. StatPearls, StatPearls Publishing."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"4189","DOI":"10.4103\/jfmpc.jfmpc_1034_21","article-title":"Etiology of obstructive jaundice and its correlation with the ethnic population of Sikkim","volume":"10","author":"Bhutia","year":"2021","journal-title":"J. Family Med. Prim. Care"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.3748\/wjg.v12.i20.3162","article-title":"Choledocholithiasis: Evolving standards for diagnosis and management","volume":"12","author":"Freitas","year":"2006","journal-title":"World J. Gastroenterol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.12669\/pjms.38.6.5084","article-title":"Investigation Study of Ultrasound Practitioners\u2019 Awareness about Artefacts of Hepatobiliary Imaging in Almadinah Almunawwarah","volume":"38","author":"Alsaedi","year":"2022","journal-title":"Pak. J. Med. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1148\/radiol.2018181942","article-title":"Percutaneous Transcholecystic Management of Choledocholithiasis: A Next Horizon for Interventional Radiologists?","volume":"290","author":"Panchanathan","year":"2019","journal-title":"Radiology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.3748\/wjg.v29.i16.2495","article-title":"Cholangioscopy-assisted extraction through novel papillary support for small-calibre and sediment-like common bile duct stones","volume":"29","author":"Zhang","year":"2023","journal-title":"World J. Gastroenterol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.4240\/wjgs.v15.i7.1262","article-title":"Pathophysiological consequences and treatment strategy of obstructive jaundice","volume":"15","author":"Liu","year":"2023","journal-title":"World J. Gastrointest. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"269","DOI":"10.5946\/ce.2020.100","article-title":"Evaluating the Revised American Society for Gastrointestinal Endoscopy Guidelines for Common Bile Duct Stone Diagnosis","volume":"54","author":"Jacob","year":"2021","journal-title":"Clin. Endosc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.bja.2023.03.012","article-title":"Consensus guidelines for the perioperative management of patients undergoing endoscopic retrograde cholangiopancreatography","volume":"130","author":"Azimaraghi","year":"2023","journal-title":"Br. J. Anaesth."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Chalya, P.L., Kanumba, E.S., and McHembe, M. (2011). Etiological spectrum and treatment outcome of Obstructive jaundice at a University teaching Hospital in northwestern Tanzania: A diagnostic and therapeutic challenges. BMC Res. Notes, 4.","DOI":"10.1186\/1756-0500-4-147"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"24","DOI":"10.4236\/ojmi.2015.51004","article-title":"Sonographic Evaluation of Obstructive Jaundice","volume":"5","author":"Gameraddin","year":"2015","journal-title":"Open J. Med. Imaging"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"705","DOI":"10.18203\/2349-2902.isj20180378","article-title":"Clinicopathological study on patients presenting with obstructive jaundice","volume":"5","author":"Shukla","year":"2018","journal-title":"Int. Surg. J."},{"key":"ref_16","unstructured":"Coucke, E.M., Akbar, H., Kahloon, A., and Lopez, P.P. (2022). Biliary Obstruction. StatPearls [Internet], StatPearls Publishing."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.18203\/2349-2902.isj20192060","article-title":"Clinical profile of patients with obstructive jaundice: A surgeon\u2019s perspectives","volume":"6","author":"Khan","year":"2019","journal-title":"Int. Surg. J."},{"key":"ref_18","first-page":"523","article-title":"Factors Affecting Morbidity and Mortality after ERCP for Obstructive Jaundice","volume":"30","author":"Hasan","year":"2021","journal-title":"Mymensingh Med. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1111\/jgs.14481","article-title":"How Does Aging Affect Presentation and Management of Biliary Stones?","volume":"64","author":"Hu","year":"2016","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"71","DOI":"10.4103\/sjg.SJG_611_17","article-title":"Management of distal malignant biliary obstruction","volume":"24","author":"Aljahdli","year":"2018","journal-title":"Saudi J. Gastroenterol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1093\/gastro\/gou072","article-title":"Biliary strictures: Diagnostic considerations and approach","volume":"3","author":"Singh","year":"2015","journal-title":"Gastroenterol. Rep."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e11476","DOI":"10.1097\/MD.0000000000011476","article-title":"Treatment of pancreatic head cancer with obstructive jaundice by endoscopy ultrasonography-guided gastrojejunostomy: A case report and literature review","volume":"97","author":"Shen","year":"2018","journal-title":"Medicine"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1136\/bmj.322.7288.721","article-title":"ABC of diseases of liver, pancreas, and biliary system. Pancreatic tumours","volume":"322","author":"Bornman","year":"2001","journal-title":"BMJ"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Ledenko, M., Antwi, S.O., Arima, S., Driscoll, J., Furuse, J., Kl\u00fcmpen, H.J., Larsen, F.O., Lau, D.K., Maderer, A., and Markussen, A. (2022). Sex-related disparities in outcomes of cholangiocarcinoma patients in treatment trials. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.963753"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"370","DOI":"10.3390\/curroncol30010030","article-title":"Pathology of Cholangiocarcinomas","volume":"30","author":"Guedj","year":"2022","journal-title":"Curr. Oncol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.bpg.2006.05.009","article-title":"Gallstone disease: Epidemiology, pathogenesis, and classification of biliary stones (common bile duct and intrahepatic)","volume":"20","author":"Tazuma","year":"2006","journal-title":"Best. Pract. Res. Clin. Gastroenterol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"79","DOI":"10.55729\/2000-9666.1114","article-title":"Mirizzi Syndrome: An Unusual Complication of Cholelithiasis","volume":"12","author":"Jesani","year":"2022","journal-title":"J. Community Hosp. Intern. Med. Perspect."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Yuan, L., Shi, X., Shan, H., Xiao, D., Wang, X., and Wang, F. (2023). Treatment of obstructive jaundice induced by non-hodgkin lymphoma with EUS-guided transgastric anterograde common bile duct stenting: Technical case report and literature review. Front. Surg., 9.","DOI":"10.3389\/fsurg.2022.1031718"},{"key":"ref_29","first-page":"294","article-title":"Hepatic artery aneurysm causing obstructive jaundice","volume":"4","author":"Julianov","year":"2014","journal-title":"Quant. Imaging Med. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1016.e1","DOI":"10.1016\/j.avsg.2014.12.011","article-title":"Obstructive jaundice caused by pancreaticoduodenal artery aneurysms associated with celiac axis stenosis: Case report and review of the literature","volume":"29","author":"Yin","year":"2015","journal-title":"Ann. Vasc. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"S707","DOI":"10.14309\/00000434-201710001-01302","article-title":"Recurrent Biliary Obstruction Secondary to Portal Vein Thrombosis with Cavernous Transformation and the Role of Cholangioscopy in Diagnosis: Case Report: 1301","volume":"112","author":"Gebreselassie","year":"2017","journal-title":"Am. J. Gastroenterol."},{"key":"ref_32","first-page":"e6683","article-title":"A Twisted Case of Jaundice","volume":"12","author":"Hoang","year":"2020","journal-title":"Cureus"},{"key":"ref_33","first-page":"e20458","article-title":"Cocaine Induced Biliary Tree Obstruction in a Middle-Aged Male","volume":"13","author":"Alexandre","year":"2021","journal-title":"Cureus"}],"container-title":["Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-9721\/12\/12\/333\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:55:45Z","timestamp":1760115345000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-9721\/12\/12\/333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,19]]},"references-count":33,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["diseases12120333"],"URL":"https:\/\/doi.org\/10.3390\/diseases12120333","relation":{},"ISSN":["2079-9721"],"issn-type":[{"value":"2079-9721","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,19]]}}}