{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T07:26:36Z","timestamp":1792135596060,"version":"4.4.0"},"reference-count":124,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T00:00:00Z","timestamp":1739577600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Development and organization of original domestic medicines production","award":["BR21882248"],"award-info":[{"award-number":["BR21882248"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>Urinary tract infections (UTIs) represent a prevalent health concern among the female population, with anatomical and physiological determinants such as a shorter urethra and its proximity to the rectum augmenting vulnerability. The presence of Escherichia coli and various other pathogens plays a significant role in the etiology of these infections, which can be aggravated by sexual intercourse and disturbances to the vaginal microbiome. The physiological alterations associated with pregnancy further elevate the likelihood of UTIs, with untreated cases potentially leading to severe complications such as pyelonephritis, preterm labor, and stillbirth. Furthermore, postmenopausal women encounter an augmented risk of UTIs attributable to estrogen deficiency and vaginal atrophy, as well as conditions including pelvic organ prolapse (POP) and urinary incontinence (UI), which hinder optimal bladder functionality. The aforementioned factors, in conjunction with the rising prevalence of cesarean deliveries and catheterization, complicate the management of UTIs. While precise diagnosis is paramount, it remains a formidable challenge, notwithstanding advancements in molecular diagnostic techniques. Management strategies encompass antibiotic-sparing therapies; however, the increasing incidence of multidrug resistance represents an alarming trend. Diverse guidelines from various medical specialties endeavor to standardize treatment approaches, yet significant inconsistencies continue to exist. This study systematically appraises the extant guidelines, evaluating the quality of evidence while identifying areas of agreement and discord to supply practitioners with effective strategies for UTI management.<\/jats:p>","DOI":"10.3390\/diseases13020059","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T11:31:17Z","timestamp":1739791877000},"page":"59","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Understanding the Burden and Management of Urinary Tract Infections in Women"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7119-950X","authenticated-orcid":false,"given":"Baiken","family":"Baimakhanova","sequence":"first","affiliation":[{"name":"LLP \u201cResearch and Production Center for Microbiology and Virology\u201d, 105 Bogenbay Batyr Str., Almaty 050010, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amankeldi","family":"Sadanov","sequence":"additional","affiliation":[{"name":"LLP \u201cResearch and Production Center for Microbiology and Virology\u201d, 105 Bogenbay Batyr Str., Almaty 050010, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2873-9635","authenticated-orcid":false,"given":"Lyudmila","family":"Trenozhnikova","sequence":"additional","affiliation":[{"name":"LLP \u201cResearch and Production Center for Microbiology and Virology\u201d, 105 Bogenbay Batyr Str., Almaty 050010, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assya","family":"Balgimbaeva","sequence":"additional","affiliation":[{"name":"LLP \u201cResearch and Production Center for Microbiology and Virology\u201d, 105 Bogenbay Batyr Str., Almaty 050010, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5416-3209","authenticated-orcid":false,"given":"Gul","family":"Baimakhanova","sequence":"additional","affiliation":[{"name":"LLP \u201cResearch and Production Center for Microbiology and Virology\u201d, 105 Bogenbay Batyr Str., Almaty 050010, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saltanat","family":"Orasymbet","sequence":"additional","affiliation":[{"name":"LLP \u201cResearch and Production Center for Microbiology and Virology\u201d, 105 Bogenbay Batyr Str., Almaty 050010, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Tleubekova","sequence":"additional","affiliation":[{"name":"LLP \u201cResearch and Production Center for Microbiology and Virology\u201d, 105 Bogenbay Batyr Str., Almaty 050010, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alma","family":"Amangeldi","sequence":"additional","affiliation":[{"name":"LLP \u201cResearch and Production Center for Microbiology and Virology\u201d, 105 Bogenbay Batyr Str., Almaty 050010, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8357-1903","authenticated-orcid":false,"given":"Zere","family":"Turlybaeva","sequence":"additional","affiliation":[{"name":"LLP \u201cResearch and Production Center for Microbiology and Virology\u201d, 105 Bogenbay Batyr Str., Almaty 050010, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0490-8000","authenticated-orcid":false,"given":"Zhanar","family":"Nurgaliyeva","sequence":"additional","affiliation":[{"name":"Department of Outpatient Pediatrics, School of Pediatrics, S.D. Asfendiyarov Kazakh National Medical University, 96 Tolebi Str., Almaty 050010, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roza","family":"Seisebayeva","sequence":"additional","affiliation":[{"name":"Department of Outpatient Pediatrics, School of Pediatrics, S.D. Asfendiyarov Kazakh National Medical University, 96 Tolebi Str., Almaty 050010, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanat","family":"Kozhekenova","sequence":"additional","affiliation":[{"name":"Department of Public Health, S.D. Asfendiyarov Kazakh National Medical University, 96 Tolebi Str., Almaty 050010, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saltanat","family":"Sairankyzy","sequence":"additional","affiliation":[{"name":"Department of Propaedeutics of Childhood Diseases, School of Pediatrics, S.D. Asfendiyarov Kazakh National Medical University, 96 Tolebi Str., Almaty 050010, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2551-0723","authenticated-orcid":false,"given":"Zhanserik","family":"Shynykul","sequence":"additional","affiliation":[{"name":"Higher School of Medicine, Al-Farabi Kazakh National University, Almaty 050040, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandugash","family":"Yerkenova","sequence":"additional","affiliation":[{"name":"Department of Public Health, S.D. 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Am."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e702","DOI":"10.3399\/bjgp15X686965","article-title":"Incidence, severity, help seeking, and management of uncomplicated urinary tract infection: A population-based survey","volume":"65","author":"Butler","year":"2015","journal-title":"Br. J. Gen. Pract."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Grobeisen-Duque, O., Mora-Vargas, C.D., Aguilera-Arreola, M.G., and Helguera-Repetto, A.C. (2023). Cycle Biodynamics of Women\u2019s Microbiome in the Urinary and Reproductive Systems. J. Clin. Med., 12.","DOI":"10.3390\/jcm12124003"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Mancuso, G., Midiri, A., Gerace, E., Marra, M., Zummo, S., and Biondo, C. (2023). Urinary Tract Infections: The Current Scenario and Future Prospects. Pathogens, 12.","DOI":"10.3390\/pathogens12040623"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Sanyaolu, L.N., Hayes, C.V., Lecky, D.M., Ahmed, H., Cannings-John, R., Weightman, A., Edwards, A., and Wood, F. (2023). Patients\u2019 and Healthcare Professionals\u2019 Experiences and Views of Recurrent Urinary Tract Infections in Women: Qualitative Evidence Synthesis and Meta-Ethnography. Antibiotics, 12.","DOI":"10.3390\/antibiotics12030434"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/clinids\/22.1.91","article-title":"Recurrence of Urinary Tract Infection in a Primary Care Setting: Analysis of a I-Year Follow-up of 179 Women","volume":"22","author":"Ikahelmo","year":"1996","journal-title":"Clin. Infect. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Mititelu, M., Olteanu, G., Neac\u0219u, S.M., Stoicescu, I., Dumitrescu, D.-E., Gheorghe, E., Tarcea, M., Busnatu, \u0218.S., Ioni\u021b\u0103-M\u00eendrican, C.-B., and Tafuni, O. (2024). Incidence of Urinary Infections and Behavioral Risk Factors. Nutrients, 16.","DOI":"10.3390\/nu16030446"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s00345-021-03913-0","article-title":"Global, Regional, and National Burden of Urinary Tract Infections from 1990 to 2019: An Analysis of the Global Burden of Disease Study 2019","volume":"40","author":"Zeng","year":"2022","journal-title":"World J. Urol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1756287218814382","DOI":"10.1177\/1756287218814382","article-title":"Risk factors and predisposing conditions for urinary tract infection","volume":"11","author":"Storme","year":"2019","journal-title":"Ther. Adv. Urol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1080\/00325481.2017.1246055","article-title":"An update on the management of urinary tract infections in the era of antimicrobial resistance","volume":"129","author":"Bader","year":"2017","journal-title":"Postgrad. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.cvsm.2015.02.005","article-title":"Urinary tract infections: Treatment\/comparative therapeutics","volume":"45","author":"Olin","year":"2015","journal-title":"Vet. Clin. N. Am. Small Anim. Pract."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s11934-007-0080-y","article-title":"Viral lower urinary tract infections","volume":"8","author":"Paduch","year":"2007","journal-title":"Curr. Urol. Rep."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Chuang, F.C., and Kuo, H.C. (2013). Increased urothelial cell apoptosis and chronic inflammation are associated with recurrent urinary tract infection in women. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0063760"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.urology.2011.09.040","article-title":"The impact of obesity on urinary tract infection risk","volume":"79","author":"Semins","year":"2012","journal-title":"Urology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s10389-020-01468-9","article-title":"Relationship between physical activity, healthy lifestyle and COVID-19 disease severity; a cross-sectional study","volume":"31","author":"Tavakol","year":"2023","journal-title":"Z. Gesundh. Wiss."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/cid\/cit646","article-title":"Recurrent urinary tract infections among women: Comparative effectiveness of 5 prevention and management strategies using a Markov chain Monte Carlo model","volume":"58","author":"Eells","year":"2014","journal-title":"Clin Infect Dis."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Kong, L.C., Holmes, B.A., Cotillard, A., Habi-Rachedi, F., Brazeilles, R., Gougis, S., Gausser\u00e8s, N., Cani, P.D., Fellahi, S., and Bastard, J.P. (2014). Dietary patterns differently associate with inflammation and gut microbiota in overweight and obese subjects. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0109434"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"80","DOI":"10.36346\/sarjm.2024.v05i03.003","article-title":"Beyond standard urine culture: Advanced molecular testing for urinary tract infections","volume":"5","author":"Carpenter","year":"2024","journal-title":"SAR J. Med."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Mestrovic, T., Matijasic, M., Peric, M., Cipcic Paljetak, H., Baresic, A., and Verbanac, D. (2020). The Role of Gut, Vaginal, and Urinary Microbiome in Urinary Tract Infections: From Bench to Bedside. Diagnostics, 11.","DOI":"10.3390\/diagnostics11010007"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1086\/425984","article-title":"Virulence Factor Profiles and Phylogenetic Background of Escherichia coli Isolates from Veterans with Bacteremia and Uninfected Control Subjects","volume":"190","author":"Sannes","year":"2004","journal-title":"J. Infect. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00192-020-04397-z","article-title":"Estrogen for the prevention of recurrent urinary tract infections in postmenopausal women: A meta-analysis of randomized controlled trials","volume":"32","author":"Chen","year":"2021","journal-title":"Int. Urogynecol. J."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Mtshali, A., San, J.E., Osman, F., Garrett, N., Balle, C., Giandhari, J., Onywera, H., Mngomezulu, K., Mzobe, G., and de Oliveira, T. (2021). Temporal Changes in Vaginal Microbiota and Genital Tract Cytokines Among South African Women Treated for Bacterial Vaginosis. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.730986"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1002\/nau.24325","article-title":"Applying concepts of life course theory and life course epidemiology to the study of bladder health and lower urinary tract symptoms among girls and women","volume":"39","author":"Brady","year":"2020","journal-title":"Neurourol. Urodyn."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1007\/s00192-022-05089-6","article-title":"Quality appraisal of clinical guidelines for recurrent urinary tract infections using AGREE II: A systematic review","volume":"33","author":"Pat","year":"2022","journal-title":"Int. Urogynecol. J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2147\/PLMI.S409488","article-title":"Microbial Threshold Guidelines for UTI Diagnosis: A Scoping Systematic Review","volume":"15","author":"Hilt","year":"2023","journal-title":"Pathol. Lab. Med. Int."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1086\/511159","article-title":"Infectious Diseases Society of America\/American Thoracic Society Consensus Guidelines on the Management of Community-Acquired Pneumonia in Adults","volume":"44","author":"Mandell","year":"2007","journal-title":"Clin. Infect. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jgar.2021.11.008","article-title":"A global perspective on improving patient care in uncomplicated urinary tract infection: Expert consensus and practical guidance","volume":"28","author":"Wagenlehner","year":"2022","journal-title":"J. Glob. Antimicrob. Resist."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e26781","DOI":"10.2196\/26781","article-title":"Using Large-scale Social Media Analytics to Understand Patient Perspectives about Urinary Tract Infections: Thematic Analysis","volume":"24","author":"Gonzalez","year":"2022","journal-title":"J. Med. Internet Res."},{"key":"ref_29","unstructured":"World Health Organization (2000). Guidelines for the Collection of Clinical Specimens During Field Investigation of Outbreaks, World Health Organization."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Chibelean, C.B., Petca, R.C., Mare\u0219, C., Popescu, R.I., Enik\u0151, B., Mehedin\u021bu, C., and Petca, A. (2020). A clinical perspective on the antimicrobial resistance spectrum of uropathogens in a Romanian male population. Microorganisms, 8.","DOI":"10.3390\/microorganisms8060848"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Grigoryan, L., Mulgirigama, A., Powell, M., and Schmiemann, G. (2022). The emotional impact of urinary tract infections in women: A qualitative analysis. BMC Womens Health, 22.","DOI":"10.1186\/s12905-022-01757-3"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1080\/17512433.2022.2121703","article-title":"A review of recent advances in the treatment of adults with complicated urinary tract infection","volume":"15","author":"Rando","year":"2022","journal-title":"Expert Rev. Clin. Pharmacol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/nri3887","article-title":"The nature of immune responses to urinary tract infections","volume":"15","author":"Abraham","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Chaban, B., Links, M.G., Jayaprakash, T.P., Wagner, E.C., Bourque, D.K., Lohn, Z., Albert, A.Y., van Schalkwyk, J., Reid, G., and Hemmingsen, S.M. (2014). Characterization of the vaginal microbiota of healthy Canadian women through the menstrual cycle. Microbiome, 2.","DOI":"10.1186\/2049-2618-2-23"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Aagaard, K., Riehle, K., Ma, J., Segata, N., Mistretta, T.A., Coarfa, C., Raza, S., Rosenbaum, S., Van den Veyver, I., and Milosavljevic, A. (2012). A metagenomic approach to characterization of the vaginal microbiome signature in pregnancy. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0036466"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"957","DOI":"10.2147\/IDR.S200988","article-title":"Comparative study of antimicrobial resistance and biofilm formation among Gram-positive uropathogens isolated from community-acquired urinary tract infections and catheter-associated urinary tract infections","volume":"12","author":"Shrestha","year":"2019","journal-title":"Infect. Drug Resist."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.jamda.2018.05.001","article-title":"The Development of a Decision Tool for the Empiric Treatment of Suspected Urinary Tract Infection in Frail Older Adults: A Delphi Consensus Procedure","volume":"19","author":"Vreeken","year":"2018","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nrmicro3432","article-title":"Urinary tract infections: Epidemiology, mechanisms of infection and treatment options","volume":"13","author":"Walker","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Hannan, T.J., Mysorekar, I.U., Hung, C.S., Isaacson-Schmid, M.L., and Hultgren, S.J. (2010). Early severe inflammatory responses to uropathogenic E. coli predispose to chronic and recurrent urinary tract infection. PLoS Pathog., 6.","DOI":"10.1371\/journal.ppat.1001042"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e15305","DOI":"10.7717\/peerj.15305","article-title":"Genotypic characteristics of Uropathogenic Escherichia coli isolated from complicated urinary tract infection (cUTI) and asymptomatic bacteriuria-a relational analysis","volume":"11","author":"Maniam","year":"2023","journal-title":"PeerJ"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e39","DOI":"10.1097\/SPV.0000000000000790","article-title":"Vaginal Estrogen Therapy Is Associated With Decreased Inflammatory Response in Postmenopausal Women With Recurrent Urinary Tract Infections","volume":"27","author":"Meister","year":"2021","journal-title":"Female Pelvic Med. Reconstr. Surg."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1177\/0962280215588241","article-title":"Estimating the sample size for a pilot randomised trial to minimise the overall trial sample size for the external pilot and main trial for a continuous outcome variable","volume":"25","author":"Whitehead","year":"2016","journal-title":"Stat. Methods Med. Res."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Cooper, E., Jones, L., Joseph, A., Allison, R., Gold, N., Larcombe, J., Moore, P., and McNulty, C. (2020). Diagnosis and management of uti in primary care settings\u2014A qualitative study to inform a diagnostic quick reference tool for women under 65 years. Antibiotics, 9.","DOI":"10.3390\/antibiotics9090581"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"100716","DOI":"10.1016\/j.nmni.2020.100716","article-title":"Prevalence and antibiotic susceptibility pattern of uropathogens in outpatients at a tertiary care hospital","volume":"36","author":"Muhammad","year":"2020","journal-title":"New Microbes New Infect."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Teglbr\u00e6nder-Bjergkvist, S., Siersma, V., and Holm, A. (2023). Severity and Bothersomeness of Urinary Tract Infection Symptoms in Women before and after Menopause. Antibiotics, 12.","DOI":"10.3390\/antibiotics12071148"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Giesen, L.G.M., Cousins, G., Dimitrov, B.D., van de Laar, F.A., and Fahey, T. (2010). Predicting Acute Uncomplicated Urinary Tract Infection in Women: A Systematic Review of the Diagnostic Accuracy of Symptoms and Signs. BMC Fam. Pract., 11.","DOI":"10.1186\/1471-2296-11-78"},{"key":"ref_47","first-page":"1","article-title":"Generalized Symptoms in Adult Women with Acute Uncomplicated Lower Urinary Tract Infection: An Observational Study","volume":"5","author":"Baerheim","year":"2003","journal-title":"MedGenMed Medscape Gen. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"E714","DOI":"10.3399\/bjgp20X712781","article-title":"Natural History of Uncomplicated Urinary Tract Infection without Antibiotics: A Systematic Review","volume":"70","author":"Hoffmann","year":"2020","journal-title":"Br. J. Gen. Pract."},{"key":"ref_49","first-page":"606","article-title":"Developing Clinical Rules to Predict Urinary Tract Infection in Primary Care Settings: Sensitivity and Specificity of near Patient Tests (Dipsticks) and Clinical Scores","volume":"56","author":"Little","year":"2006","journal-title":"Br. J. Gen. Pract."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e043328","DOI":"10.1136\/bmjopen-2020-043328","article-title":"Psychometric Properties of a Self-Assessment Questionnaire Concerning Symptoms and Impairment in Urinary Tract Infections: The UTI-SIQ-8","volume":"11","author":"Rentzsch","year":"2021","journal-title":"BMJ Open"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e039871","DOI":"10.1136\/bmjopen-2020-039871","article-title":"Diagnosis of Urinary Tract Infection Based on Symptoms: How Are Likelihood Ratios Affected by Age? A Diagnostic Accuracy Study","volume":"11","author":"Holm","year":"2021","journal-title":"BMJ Open"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Chegini, Z., Khoshbayan, A., Vesal, S., Moradabadi, A., Hashemi, A., and Shariati, A. (2021). Bacteriophage therapy for inhibition of multi drug-resistant uropathogenic bacteria: A narrative review. Ann. Clin. Microbiol. Antimicrob., 20.","DOI":"10.1186\/s12941-021-00433-y"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1128\/CMR.00037-09","article-title":"Three decades of beta-lactamase inhibitors","volume":"23","author":"Drawz","year":"2010","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1007\/s11136-023-03348-7","article-title":"Development and psychometric validation of a patient-reported outcome measure of recurrent urinary tract infection impact: The Recurrent UTI Impact Questionnaire","volume":"32","author":"Newlands","year":"2023","journal-title":"Qual Life Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1097\/JU.0000000000000296","article-title":"Recurrent uncomplicated urinary tract infections in women: AUA\/CUA\/SUFU guideline","volume":"202","author":"Anger","year":"2019","journal-title":"J. Urol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1046\/j.1198-743x.2001.00237.x","article-title":"European Guidelines for Urinalysis: A Collaborative Document Produced by European Clinical Microbiologists and Clinical Chemists under ECLM in Collaboration with ESCMID","volume":"7","author":"Aspevall","year":"2001","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_57","first-page":"CD001405","article-title":"Oestrogen therapy for urinary incontinence in post-menopausal women","volume":"10","author":"Cody","year":"2012","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_58","first-page":"157","article-title":"Multiple Imputation for Missing Data in Epidemiological and Clinical Research: Potential and Pitfalls","volume":"339","author":"Sterne","year":"2009","journal-title":"BMJ"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.2337\/diacare.25.10.1778","article-title":"Diabetes and the risk of acute urinary tract infection among postmenopausal women","volume":"25","author":"Boyko","year":"2002","journal-title":"Diabetes Care"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Cobo, T., Vergara, A., Collado, M.C., Herreros, E., Bosch, J., Sanchez-Garcia, A.B., Lopez-Parellada, R., Ponce, J., and Gratacos, E. (2019). Characterization of vaginal microbiota in women with preterm labor with intra-amniotic inflammation. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-55611-y"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/ajo.12754","article-title":"A retrospective pilot study to determine whether the reproductive tract microbiota differs between women with a history of infertility and fertile women","volume":"58","author":"Wee","year":"2018","journal-title":"Aust. N. Z. J. Obstet. Gynaecol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1093\/humrep\/dew026","article-title":"Abnormal vaginal microbiota may be associated with poor reproductive outcomes: A prospective study in IVF patients","volume":"31","author":"Haahr","year":"2016","journal-title":"Hum. Reprod."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/1471-0528.15920","article-title":"The urobiome of continent adult women: A cross-sectional study","volume":"127","author":"Price","year":"2020","journal-title":"BJOG"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Moustafa, A., Li, W., Singh, H., Moncera, K.J., Torralba, M.G., Yu, Y., Manuel, O., Biggs, W., Venter, J.C., and Nelson, K.E. (2018). Microbial metagenome of urinary tract infection. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-22660-8"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Govender, Y., Gabriel, I., Minassian, V., and Fichorova, R. (2019). The Current Evidence on the Association Between the Urinary Microbiome and Urinary Incontinence in Women. Front. Cell. Infect. Microbiol., 9.","DOI":"10.3389\/fcimb.2019.00133"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Lee, D.S., Lee, S.J., and Choe, H.S. (2018). Community-Acquired Urinary Tract Infection by Escherichia coli in the Era of Antibiotic Resistance. BioMed Res. Int., 2018.","DOI":"10.1155\/2018\/7656752"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s40545-020-00292-6","article-title":"Patterns of infections and antimicrobial drugs\u2019 prescribing among pregnant women in Saudi Arabia: A cross sectional study","volume":"14","author":"Baraka","year":"2021","journal-title":"J. Pharm. Policy Pract."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"101516","DOI":"10.1016\/j.ajogmf.2024.101516","article-title":"Implementation of an algorithm for testing, diagnosis, and antibiotic stewardship of asymptomatic bacteriuria in pregnancy","volume":"6","author":"Bergbower","year":"2024","journal-title":"Am. J. Obstet. Gynecol. MFM"},{"key":"ref_69","first-page":"w20236","article-title":"Guideline of the Swiss Society of Gynaecology and Obstetrics (SSGO) on acute and recurrent urinary tract infections in women, including pregnancy","volume":"150","author":"Betschart","year":"2020","journal-title":"Schweiz. Med. Wochenschr."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1128\/microbiolspec.UTI-0012-2012","article-title":"Gram-Positive Uropathogens, Polymicrobial Urinary Tract Infection, and the Emerging Microbiota of the Urinary Tract","volume":"4","author":"Kline","year":"2016","journal-title":"Microbiol. Spectr."},{"key":"ref_71","first-page":"40","article-title":"Urinary tract infection in women","volume":"20","author":"Czajkowski","year":"2021","journal-title":"Prz. Menopauzalny"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.3760\/cma.j.issn.0366-6999.20133072","article-title":"Immune system modifications and feto-maternal immune tolerance","volume":"127","author":"Song","year":"2014","journal-title":"Chin. Med. J."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.fmre.2022.06.011","article-title":"A dynamic peripheral immune landscape during human pregnancy","volume":"5","author":"Liu","year":"2022","journal-title":"Fundam. Res."},{"key":"ref_74","first-page":"853","article-title":"Urinary tract infections in pregnancy","volume":"54","author":"Lee","year":"2008","journal-title":"Can. Fam. Physician"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2155041","DOI":"10.1080\/14767058.2022.2155041","article-title":"Acute pyelonephritis in pregnancy and plasma syndecan-1: Evidence of glycocalyx involvement","volume":"36","author":"Immonen","year":"2023","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1111\/jog.12411","article-title":"Impact of first trimester fasting glycemic levels on expression of proteoglycans in pregnancy","volume":"40","author":"Capobianco","year":"2014","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/bju.15756","article-title":"Guideline of guidelines: Management of recurrent urinary tract infections in women","volume":"130","author":"Kwok","year":"2022","journal-title":"BJU Int."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.eururo.2020.06.032","article-title":"The EAU and AUA\/CUA\/SUFU Guidelines on Recurrent Urinary Tract Infections: What is the Difference?","volume":"78","author":"Naber","year":"2020","journal-title":"Eur. Urol."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Zhang, S., Li, G., Qiao, L., Lai, D., He, Z., An, L., Xu, P., Tiselius, H.-G., Zeng, G., and Zheng, J. (2022). The antibiotic strategies during percutaneous nephrolithotomy in China revealed the gap between the reality and the urological guidelines. BMC Urol., 22.","DOI":"10.1186\/s12894-022-01092-7"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"403","DOI":"10.33073\/pjm-2019-048","article-title":"Antibiotic Resistance Among Uropathogenic Escherichia coli","volume":"68","author":"Kot","year":"2019","journal-title":"Pol. J. Microbiol."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Prieto, J.M., and Schinella, G.R. (2022). Anti-Inflammatory and Antioxidant Chinese Herbal Medicines: Links between Traditional Characters and the Skin Lipoperoxidation \u201cWestern\u201d Model. Antioxidants, 11.","DOI":"10.3390\/antiox11040611"},{"key":"ref_82","first-page":"CD010446","article-title":"Chinese herbal medicine for treating recurrent urinary tract infections in women","volume":"6","author":"Flower","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"ofac327","DOI":"10.1093\/ofid\/ofac327","article-title":"Antibiotics for Preventing Recurrent Urinary Tract Infection: Systematic Review and Meta-analysis","volume":"9","author":"Jent","year":"2022","journal-title":"Open Forum Infect. Dis."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2217\/14750708.6.2.145","article-title":"Application and comparison of the AUA and EAU current recommendations for antibiotic prophylaxis in the urologic patient undergoing office procedures","volume":"6","author":"Koepke","year":"2009","journal-title":"Therapy"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"13","DOI":"10.5489\/cuaj.2382","article-title":"CUA Guidelines on antibiotic prophylaxis for urologic procedures","volume":"9","author":"Mrkobrada","year":"2015","journal-title":"CUAJ-Can. Urol. Assoc. J."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Meng, H.-H., Xu, D., Wang, Q., Liu, L., Liu, W., and Wang, J. (2023). Maintaining Immune Homeostasis with Coptis Chinensis Water Extract to Mitigate Sepsis Severity via Modulating Gut Microbiome and Metabolism. J. Pharm. Biomed. Anal., 236.","DOI":"10.1016\/j.jpba.2023.115719"},{"key":"ref_87","first-page":"395","article-title":"Uropathogens antibiotic susceptibility as an indicator for the empirical therapy used for urinary tract infections: A retrospective observational study","volume":"12","author":"Luty","year":"2020","journal-title":"Iran. J. Microbiol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.2147\/IDR.S185753","article-title":"Risk factors and prognosis of complicated urinary tract infections caused by Pseudomonas aeruginosa in hospitalized patients: A retrospective multicenter cohort study","volume":"11","author":"Gomila","year":"2018","journal-title":"Infect. Drug Resist."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Karibayeva, I., Moiynbayeva, S., Akhmetov, V., Yerkenova, S., Shaikova, K., Moshkalova, G., Mussayeva, D., and Tarakova, B. (2024). Interrupted time series analysis of the impact of the COVID-19 pandemic and compulsory social health insurance system on fertility rates: A study of live births in Kazakhstan, 2019\u20132023. Front. Public Health, 12.","DOI":"10.3389\/fpubh.2024.1454420"},{"key":"ref_90","first-page":"1122","article-title":"Preconception care to improve pregnancy outcomes in COVID-19 survival Women: A systematic review","volume":"11","author":"Yerkenova","year":"2023","journal-title":"Res. J. Pharm. Technol."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Engels\u00f6y, U., Svensson, M.A., and Demirel, I. (2021). Estradiol Alters the Virulence Traits of Uropathogenic Escherichia coli. Front. Microbiol., 12.","DOI":"10.3389\/fmicb.2021.682626"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Pendharkar, S., Skafte-Holm, A., Simsek, G., and Haahr, T. (2023). Lactobacilli and Their Probiotic Effects in the Vagina of Reproductive Age Women. Microorganisms, 11.","DOI":"10.3390\/microorganisms11030636"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1086\/375819","article-title":"Association between Acquisition of Herpes Simplex Virus Type 2 in Women and Bacterial Vaginosis","volume":"37","author":"Cherpes","year":"2003","journal-title":"Clin. Infect. Dis."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Skafte-Holm, A., Humaidan, P., Bernabeu, A., Lledo, B., Jensen, J.S., and Haahr, T. (2021). The Association between Vaginal Dysbiosis and Reproductive Outcomes in Sub-Fertile Women Undergoing IVF-Treatment: A Systematic PRISMA Review and Meta-Analysis. Pathogens, 10.","DOI":"10.3390\/pathogens10030295"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1093\/humrep\/deab002","article-title":"Association between Bacterial Vaginosis and Fecundability in Kenyan Women Planning Pregnancies: A Prospective Preconception Cohort Study","volume":"36","author":"Lokken","year":"2021","journal-title":"Hum. Reprod."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.bpobgyn.2006.12.005","article-title":"Asymptomatic Bacterial Vaginosis and Intermediate Flora as Risk Factors for Adverse Pregnancy Outcome","volume":"21","author":"Leitich","year":"2007","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Amabebe, E., and Anumba, D.O.C. (2018). The Vaginal Microenvironment: The Physiologic Role of Lactobacilli. Front. Med., 5.","DOI":"10.3389\/fmed.2018.00181"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Zheng, N., Guo, R., Wang, J., Zhou, W., and Ling, Z. (2021). Contribution of Lactobacillus Iners to Vaginal Health and Diseases: A Systematic Review. Front. Cell. Infect. Microbiol., 11.","DOI":"10.3389\/fcimb.2021.792787"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/humupd\/dmu065","article-title":"Antimicrobial Peptides in the Female Reproductive Tract: A Critical Component of the Mucosal Immune Barrier with Physiological and Clinical Implications","volume":"21","author":"Yarbrough","year":"2015","journal-title":"Hum. Reprod. Update"},{"key":"ref_100","first-page":"CD008772","article-title":"Probiotics for preventing urinary tract infections in adults and children","volume":"2015","author":"Schwenger","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Yazdanpour, Z., Tadjrobehkar, O., and Shahkhah, M. (2020). Significant association between genes encoding virulence factors with antibiotic resistance and phylogenetic groups in community acquired uropathogenic Escherichia coli isolates. BMC Microbiol., 20.","DOI":"10.1186\/s12866-020-01933-1"},{"key":"ref_102","first-page":"45","article-title":"Fosfomycin in infections caused by multidrug-resistant Gram-negative pathogens","volume":"32","year":"2019","journal-title":"Rev. Esp. Quimioter."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"e0149221","DOI":"10.1128\/aac.01492-21","article-title":"Dose Selection for Phase III Clinical Evaluation of Gepotidacin (GSK2140944) in the Treatment of Uncomplicated Urinary Tract Infections","volume":"66","author":"Hossain","year":"2022","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1007\/s40121-021-00509-4","article-title":"Oral Antibiotics in Clinical Development for Community-Acquired Urinary Tract Infections","volume":"10","author":"Veeraraghavan","year":"2021","journal-title":"Infect. Dis. Ther."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"4228","DOI":"10.1039\/C9TB02243K","article-title":"A photoluminescence biosensor for the detection of N-acyl homoserine lactone using cysteamine functionalized ZnO nanoparticles for the early diagnosis of urinary tract infections","volume":"8","author":"Vasudevan","year":"2020","journal-title":"J. Mater. Chem. B"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"156911","DOI":"10.1016\/j.scitotenv.2022.156911","article-title":"Pluripotency of endogenous AHL-mediated quorum sensing in adaptation and recovery of biological nitrogen removal system under ZnO nanoparticle long-term exposure","volume":"842","author":"Gao","year":"2022","journal-title":"Sci. Total Environ."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"180955","DOI":"10.1098\/rsos.180955","article-title":"Portable bacteria-capturing chip for direct surface-enhanced Raman scattering identification of urinary tract infection pathogens","volume":"5","author":"Yang","year":"2018","journal-title":"R. Soc. Open Sci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"21684","DOI":"10.1021\/acsomega.9b02080","article-title":"Rapid Colorimetric Detection of Pseudomonas aeruginosa in Clinical Isolates Using a Magnetic Nanoparticle Biosensor","volume":"4","author":"Alhogail","year":"2019","journal-title":"ACS Omega"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Cattoir, V., Gilibert, A., Le Glaunec, J.-M., Launay, N., Bait-M\u00e9rabet, L., and Legrand, P. (2010). Rapid detection of Pseudomonas aeruginosa from positive blood cultures by quantitative PCR. Ann. Clin. Microbiol. Antimicrob., 9.","DOI":"10.1186\/1476-0711-9-21"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1111\/j.1365-2672.2011.05107.x","article-title":"Rapid and sensitive detection of Pseudomonas aeruginosa in chlorinated water and aerosols targeting gyrB gene using real-time PCR","volume":"111","author":"Lee","year":"2011","journal-title":"J. Appl. Microbiol."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Yang, J., Wang, X., Sun, Y., Chen, B., Hu, F., Guo, C., and Yang, T. (2023). Recent Advances in Colorimetric Sensors Based on Gold Nanoparticles for Pathogen Detection. Biosensors, 13.","DOI":"10.3390\/bios13010029"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1097\/MOP.0000000000000523","article-title":"Fidget spinners: Purported benefits, adverse effects and accepted alternatives","volume":"29","author":"Schecter","year":"2017","journal-title":"Curr. Opin. Pediatr."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"13468","DOI":"10.1073\/pnas.1606324113","article-title":"Siderophore vaccine conjugates protect against uropathogenic Escherichia coli urinary tract infection","volume":"113","author":"Mike","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_114","first-page":"7916","article-title":"Mobile origami immunosensors for the rapid detection of urinary tract infections","volume":"145","author":"Clemente","year":"2021","journal-title":"Analyst"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"e008894","DOI":"10.1136\/bmjopen-2015-008894","article-title":"Using qualitative insights to change practice: Exploring the culture of antibiotic prescribing and consumption for urinary tract infections","volume":"6","author":"Duane","year":"2016","journal-title":"BMJ Open"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.bios.2010.07.002","article-title":"Electrochemical immunosensor detection of urinary lactoferrin in clinical samples for urinary tract infection diagnosis","volume":"26","author":"Pan","year":"2010","journal-title":"Biosens. Bioelectron."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1097\/01.ju.0000155595.98120.8e","article-title":"Urologic Diseases in America Project: Trends in Resource Use for Urinary Tract Infections in Men","volume":"173","author":"Griebling","year":"2005","journal-title":"J. Urol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s12223-019-00759-3","article-title":"Probiotics and prebiotics potential for the care of skin, female urogenital tract, and respiratory tract","volume":"65","author":"Bustamante","year":"2020","journal-title":"Folia Microbiol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"27042","DOI":"10.1039\/D0RA03306E","article-title":"Quantitative determination of leukocyte esterase with a paper-based device","volume":"10","author":"Ho","year":"2020","journal-title":"RSC Adv."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Wang, D., Loo, J.F.C., Chen, J., Yam, Y., Chen, S.-C., He, H., Kong, S.K., and Ho, H.P. (2019). Recent Advances in Surface Plasmon Resonance Imaging Sensors. Sensors, 19.","DOI":"10.3390\/s19061266"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Rafiee, M., Chandra, S., Ahmed, H., and McCormack, S.J. (2021). Optimized 3D Finite-Difference-Time-Domain Algorithm to Model the Plasmonic Properties of Metal Nanoparticles with Near-Unity Accuracy. Chemosensors, 9.","DOI":"10.3390\/chemosensors9050114"},{"key":"ref_122","first-page":"217","article-title":"How to avoid drug resistance during treatment and prevention of urinary tract infections","volume":"20","author":"Warzecha","year":"2021","journal-title":"Prz. Menopauzalny"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"14","DOI":"10.18773\/austprescr.2019.002","article-title":"Nitrofurantoin and fosfomycin for resistant urinary tract infections: Old drugs for emerging problems","volume":"42","author":"Gardiner","year":"2019","journal-title":"Aust. Prescr."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1093\/jac\/dkad287","article-title":"Nitrofurantoin: What is the evidence for current UK guidance?","volume":"78","author":"Kashouris","year":"2023","journal-title":"J. Antimicrob. Chemother."}],"container-title":["Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-9721\/13\/2\/59\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:35:17Z","timestamp":1760027717000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-9721\/13\/2\/59"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,15]]},"references-count":124,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["diseases13020059"],"URL":"https:\/\/doi.org\/10.3390\/diseases13020059","relation":{},"ISSN":["2079-9721"],"issn-type":[{"value":"2079-9721","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,15]]}}}