{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:22:25Z","timestamp":1790821345656,"version":"4.1.0"},"reference-count":41,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>Candidemia and invasive candidiasis represent critical healthcare-associated fungal infections that pose substantial challenges to medical systems worldwide. These conditions arise when fungi from the Candida genus infiltrate the bloodstream or deeper tissues, leading to a range of clinical manifestations. Among the various species, Candida albicans continues to hold its position as the most frequently encountered causative agent, largely due to its prevalence and adaptability within human hosts. However, it is far from the only significant player; other Candida species, such as Candida glabrata, Candida parapsilosis, and the particularly concerning Candida auris, contribute significantly to the disease burden and exhibit varying dominance depending on geographic regions. The clinical presentation of these infections can differ widely, spanning from subtle, almost imperceptible symptoms in some patients to severe, life-threatening fulminant sepsis in others, often accompanied by alarmingly high mortality rates that underscore the urgency of effective management strategies. Several well-established risk factors predispose individuals to developing invasive candidiasis and candidemia. Breaches in the body\u2019s natural barriers\u2014such as the skin (cutaneous) or the gastrointestinal (GI) tract\u2014provide entry points for these opportunistic pathogens. Additionally, deficiencies in the host\u2019s immune responses, whether due to medical treatments, underlying diseases, or genetic predispositions, heighten vulnerability to infection. Among the diverse Candida species, Candida auris has emerged as an especially troubling entity in recent years. This multidrug-resistant species is notorious for its resistance to standard antifungal therapies, which complicates treatment efforts and contributes to elevated morbidity and mortality rates. Its rapid global spread has positioned it as a formidable public health threat, prompting heightened surveillance and research into its behavior and control.<\/jats:p>","DOI":"10.3390\/diseases13040093","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T11:01:00Z","timestamp":1743073260000},"page":"93","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["A Comprehensive Review of Candidemia and Invasive Candidiasis in Adults: Focus on the Emerging Multidrug-Resistant Fungus Candida auris"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7596-5373","authenticated-orcid":false,"given":"Deobrat Chandra","family":"Mallick","sequence":"first","affiliation":[{"name":"Christus Spohn Hospital Shoreline, 600 Elizabeth St, Corpus Christi, TX 78404, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1515-2114","authenticated-orcid":false,"given":"Nayanjyoti","family":"Kaushik","sequence":"additional","affiliation":[{"name":"CHI Health Nebraska Heart Institute, 7440 S 91st, Lincon, NE 68526, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lokesh","family":"Goyal","sequence":"additional","affiliation":[{"name":"Christus Spohn Hospital Shoreline, 600 Elizabeth St, Corpus Christi, TX 78404, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lipika","family":"Mallick","sequence":"additional","affiliation":[{"name":"College of Arts and Science, Cornell University, Ithaca, NY 14850, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5264-2557","authenticated-orcid":false,"given":"Prabhat","family":"Singh","sequence":"additional","affiliation":[{"name":"Kidney Specialist of South Texas, 1521 S Staple St, Corpus Christi, TX 78413, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/cid\/civ933","article-title":"Clinical practice guideline for the management of candidiasis: 2016 update by the Infectious Diseases Society of America","volume":"62","author":"Pappas","year":"2016","journal-title":"Clin. 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