{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:29:39Z","timestamp":1789129779744,"version":"build-2803163510"},"reference-count":29,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>Background: Transcatheter aortic valve replacement (TAVR) has become the preferred treatment for severe aortic stenosis in high- and intermediate-risk patients, with expanding indications for lower-risk populations. However, post-procedural complications, such as stroke, conduction disturbances, and heart failure readmissions, remain concerns. The aim of our study is to analyze the national trends in TAVR procedures, in-hospital outcomes, major readmission causes, and the association of risk factors for readmissions following TAVR. Methods: We analyzed NIS data (2018\u20132022) to assess TAVR utilization trends, patient demographics, and in-hospital outcomes. The NRD (2021\u20132022) was used to evaluate 60-day readmission rates for stroke, complete heart block, and heart failure. Multivariate regression models were employed to identify risk factors having significant association with major readmission causes. Results: TAVR utilization increased from 10,788 cases in 2018 to 17,784 in 2022, with a concurrent decrease in in-hospital mortality (1.33% to 0.90%) and length of stay (3.88 to 2.97 days). Of 123,376 TAVR index admissions in 2021, 28,654 patients had 66,100 readmission events (53.57%) in the 60 days following discharge. Heart failure (17,566 cases, 26.57% of readmissions) was the most common readmission cause, followed by complete heart block (1760 cases, 2.66% of readmissions) and stroke (284 cases, 0.42% of readmissions). Predictors of post-TAVR stroke included uncontrolled hypertension (OR 2.29, p &lt; 0.001) and chronic heart failure (OR 2.73, p &lt; 0.001). Left bundle branch block (LBBB) was strongly associated with complete heart block (OR 12.89, p &lt; 0.001) and heart failure readmissions (OR 7.65, p &lt; 0.001). Conclusions: TAVR utilization has increased with improving perioperative outcomes, but post-TAVR readmissions remain significant, particularly for heart failure, stroke, and conduction disturbances. Pre-procedural uncontrolled hypertension, hyperlipidemia, congestive heart failure, and atrial fibrillation were risk factors with significant association with stroke in the 60 days following TAVR. The presence of documented pre-procedural LBB, RBB, as well as BFB were risk factors with significant association with complete heart block following TAVR placements. Pre-procedural LBB, RBB, BFB, and atrial fibrillation were risk factors having significant association with heart failure readmissions in the 60 days following TAVR.<\/jats:p>","DOI":"10.3390\/diseases13050149","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T03:59:26Z","timestamp":1747108766000},"page":"149","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Trends and Outcomes of TAVR: An Analysis Using the National Inpatient Sample and Readmissions Database"],"prefix":"10.3390","volume":"13","author":[{"given":"Vivek Joseph","family":"Varughese","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of South Carolina, Prisma Health, Columbia, SC 29201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vignesh Krishnan","family":"Nagesh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of South Carolina, Prisma Health, Columbia, SC 29201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadrian Hoang-Vu","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hackensack Palisades Medical Center, North Bergen, NJ 07047, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Yessin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of South Carolina, Prisma Health, Columbia, SC 29201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsh","family":"Jha","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of South Carolina, Prisma Health, Columbia, SC 29201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Mason","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of South Carolina, Prisma Health, Columbia, SC 29201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Thu","sequence":"additional","affiliation":[{"name":"Touro College of Medicine, New York, NY 10027, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simcha","family":"Weissman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hackensack Palisades Medical Center, North Bergen, NJ 07047, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Atoot","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hackensack Palisades Medical Center, North Bergen, NJ 07047, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e007147","DOI":"10.1161\/JAHA.117.007147","article-title":"Transcatheter aortic valve replacement in intermediate- and low-risk patients","volume":"7","author":"Rogers","year":"2018","journal-title":"J. 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