{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:18:45Z","timestamp":1760059125971,"version":"build-2065373602"},"reference-count":19,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>Background: Essential thrombocythemia (ET) is a myeloproliferative neoplasm characterized by the uncontrolled proliferation of megakaryocytes and sustained thrombocytosis. Although its impact on renal function is not well established, a few case reports have described glomerular involvement and associated kidney impairment. Case Report: We present the case of a 79-year-old man with ET and stage 3b\/A2 chronic kidney disease (CKD), who was admitted with severe acute kidney injury (AKI). This episode was associated with a progressive rise in platelet count, reaching 1,350,000\/\u03bcL after discontinuation of anagrelide and loop diuretics. Renal biopsy (RB) revealed structural lesions compatible with a myeloproliferative neoplasm, including acute tubular necrosis (ATN), glomerulomegaly, and thrombotic microangiopathy (TMA). Cytoreductive therapy with hydroxyurea and corticosteroids was initiated, resulting in improvement of renal function and achievement of complete hematologic remission. Discussion: During follow-up, a linear correlation was observed between increasing platelet counts and declining renal function, underscoring the need for dynamic therapeutic adjustment and close monitoring to prevent progression to end-stage renal disease (ESRD). Conclusions: This case highlights the importance of nephrological evaluation in patients with ET and supports the role of cytoreductive therapy in managing ET-associated renal complications.<\/jats:p>","DOI":"10.3390\/diseases13050162","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T09:58:22Z","timestamp":1747821502000},"page":"162","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Unusual Case of Essential Thrombocythemia and Acute Kidney Injury: Case Report and Literature Review"],"prefix":"10.3390","volume":"13","author":[{"given":"Celia","family":"Rodr\u00edguez Tudero","sequence":"first","affiliation":[{"name":"Department of Nephrology, Hospital Universitario de Salamanca, 37007 Salamanca, Spain"},{"name":"Surgery Doctoral Program, Faculty of Medicine, University of Salamanca, 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Mart\u00edn Arribas","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital Universitario de Salamanca, 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Ant\u00fanez Plaza","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology, Hospital Universitario de Salamanca, 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9346-2279","authenticated-orcid":false,"given":"Jos\u00e9","family":"De La Flor","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital Central Defense Gomez Ulla, 280467 Madrid, Spain"},{"name":"Health Sciences Doctoral Program, Faculty of Medicine, Alcala University, 28805 Madrid, Spain"},{"name":"Department of Medicine and Medical Specialties, Faculty of Medicine, Alcala University, 28805 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Lizarazo Su\u00e1rez","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital Universitario de Salamanca, 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0715-6553","authenticated-orcid":false,"given":"Mar\u00eda","family":"Fraile-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital Universitario de Salamanca, 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,21]]},"reference":[{"key":"ref_1","unstructured":"Sociedad de Leucemia y Linfoma (s.f.) (2025, April 11). Trombocitemia Esencial (TE). Available online: https:\/\/www.lls.org\/sites\/default\/files\/file_assets\/sp_essentialprimarythrombocythemia.pdf."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/ki.2011.147","article-title":"Myeloproliferative neoplasms cause glomerulopathy","volume":"80","author":"Said","year":"2011","journal-title":"Kidney Int."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.revmed.2012.12.013","article-title":"[Myeloproliferative neoplasms related glomerulopathy]","volume":"34","author":"Paule","year":"2013","journal-title":"La Rev. Med. Interne"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s12185-020-02898-7","article-title":"Chronic kidney disease could be a risk factor for thrombosis in essential thrombocythemia and polycythemia vera","volume":"112","author":"Holik","year":"2020","journal-title":"Int. J. Hematol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1182\/blood-2015-04-638593","article-title":"White blood cell counts and thrombosis in polycythemia vera: A subanalysis of the CYTO-PV study","volume":"126","author":"Barbui","year":"2015","journal-title":"Blood"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e196","DOI":"10.1016\/S2352-3026(19)30236-4","article-title":"Ropeginterferon alfa-2b versus standard therapy for polycythaemia vera (PROUD-PV and CONTINUATION-PV): A randomised, non-inferiority, phase 3 trial and its extension study","volume":"7","author":"Gisslinger","year":"2020","journal-title":"Lancet Haematol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1002\/ajh.26008","article-title":"Polycythemia vera and essential thrombocythemia: 2021 update on diagnosis, risk-stratification and management","volume":"95","author":"Tefferi","year":"2020","journal-title":"Am. J. Hematol."},{"key":"ref_8","first-page":"609","article-title":"Thrombocytosis and thrombocythemia","volume":"88","author":"Mitus","year":"1990","journal-title":"Am. J. Med."},{"key":"ref_9","first-page":"2341","article-title":"Hydroxyurea in essential thrombocythemia: A systematic review and meta-analysis","volume":"5","author":"Finazzi","year":"2021","journal-title":"Blood Adv."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.kint.2021.05.021","article-title":"KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases","volume":"100","author":"Rovin","year":"2021","journal-title":"Kidney Int."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/s41581-021-00405-7","article-title":"Kidney injury and disease in patients with haematological malignancies","volume":"17","author":"Bridoux","year":"2021","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Gecht, J., Tsoukakis, I., Kricheldorf, K., Stegelmann, F., Klausmann, M., Griesshammer, M., Schulz, H., Hollburg, W., G\u00f6thert, J.R., and Sockel, K. (2021). Kidney Dysfunction Is Associated with Thrombosis and Disease Severity in Myeloproliferative Neoplasms: Implications from the German Study Group for MPN Bioregistry. Cancers, 13.","DOI":"10.3390\/cancers13164086"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.kint.2023.09.010","article-title":"The spectrum of glomerular and vascular kidney pathology associated with myeloproliferative neoplasms","volume":"104","author":"Isnard","year":"2023","journal-title":"Kidney Int."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1111\/his.14282","article-title":"Renal disease associated with myeloproliferative and myelodysplastic\/myeloproliferative neoplasia","volume":"78","author":"Sticht","year":"2021","journal-title":"Histopathology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1080\/17474086.2022.2039117","article-title":"Renal disease associated with chronic myeloproliferative neoplasms","volume":"15","author":"Lucijanic","year":"2022","journal-title":"Expert Rev. Hematol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1056\/NEJMoa043800","article-title":"Hydroxyurea compared with anagrelide in high-risk essential thrombocythemia","volume":"353","author":"Harrison","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e369","DOI":"10.1038\/bcj.2015.94","article-title":"Practice-relevant revision of IPSET-thrombosis based on 1019 patients with WHO-defined essential thrombocythemia","volume":"5","author":"Barbui","year":"2015","journal-title":"Blood Cancer J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"412","DOI":"10.5414\/CNP68412","article-title":"Focal segmental glomerulosclerosis associated with polycythemia vera: Report of a case and review of the literature","volume":"68","author":"Okuyama","year":"2007","journal-title":"Clin. Nephrol."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Jain, A. (2025). A young woman with severe renovascular hypertension due to essential thrombocytosis: Case report and literature review. J. 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