{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:46:00Z","timestamp":1777589160609,"version":"3.51.4"},"reference-count":69,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>Fanconi anemia (FA) is characterized by faulty DNA repair and is associated with bone marrow failure, acute myeloid leukemia (AML), and myelodysplastic syndrome (MDS). Because of the more widespread use of next-generation sequencing (NGS) and increased testing for germline mutations in young patients with MDS and AML, FA is increasingly being first diagnosed in adults, many of whom lack classical physical stigmata. Hematopoietic stem cell transplant is the only cure for the hematologic manifestations of FA but there are several unique considerations in FA patients, including first maintaining a high index of suspicion for the diagnosis in patients with minimal phenotypic abnormalities, second an exaggerated sensitivity to alkylating agents and radiation, precluding the use of standard myeloablative conditioning regimens despite the young age of most of the patients, and lastly a marked propensity for squamous cell cancers of the upper aerodigestive tract and anogenital region, likely further increased by the drugs used in conditioning and by chronic inflammation in patients who develop graft-versus-host disease. Despite a growing number of FA patients surviving into adulthood or first being diagnosed with FA as an adult, there is minimal literature describing transplant methodology and outcomes. In the following case-based review of a patient, we incorporate recent findings from the literature on the care of this challenging patient population.<\/jats:p>","DOI":"10.3390\/diseases13070195","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T08:23:22Z","timestamp":1750839802000},"page":"195","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hematopoietic Stem Cell Transplant in Adult Patients with Fanconi Anemia: A Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0079-8450","authenticated-orcid":false,"given":"Bradley","family":"Rockwell","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, 111 E 210th Street, Bronx, NY 10467, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9875-1841","authenticated-orcid":false,"given":"Prakriti","family":"Ramamurthy","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, 111 E 210th Street, Bronx, NY 10467, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1540-0951","authenticated-orcid":false,"given":"Jhannine Alyssa","family":"Verceles","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, 111 E 210th Street, Bronx, NY 10467, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Lombardo","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, 111 E 210th Street, Bronx, NY 10467, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, 111 E 210th Street, Bronx, NY 10467, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0233-8876","authenticated-orcid":false,"given":"Dennis L.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Montefiore Medical Center, Albert Einstein College of Medicine, 111 E 210th Street, Bronx, NY 10467, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/bjh.14615","article-title":"How I manage patients with Fanconi anaemia","volume":"178","author":"Dufour","year":"2017","journal-title":"Br. J. Haematol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.mrfmmm.2009.01.013","article-title":"Fanconi Anemia and its Diagnosis","volume":"668","author":"Auerbach","year":"2009","journal-title":"Mutat. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1182\/hematology.2022000393","article-title":"Modern management of Fanconi anemia","volume":"2022","author":"Dufour","year":"2022","journal-title":"Hematol. Am. Soc. Hematol. Educ. Program"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"a005595","DOI":"10.1101\/mcs.a005595","article-title":"Esophageal cancer as initial presentation of Fanconi anemia in patients with a hypomorphic FANCA variant","volume":"6","author":"Lach","year":"2020","journal-title":"Cold Spring Harb. Mol. Case Stud."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/s41586-022-05253-4","article-title":"Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancer","volume":"612","author":"Webster","year":"2022","journal-title":"Nature"},{"key":"ref_6","unstructured":"Adam, M.P., Feldman, J., Mirzaa, G.M., Pagon, R.A., Wallace, S.E., Bean, L.J., Gripp, K.W., and Amemiya, A. (2024, February 12). Fanconi Anemia, GeneReviews\u00ae [Internet], Available online: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1401\/."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/bjh.15006","article-title":"Transplant results in adults with Fanconi anaemia","volume":"180","author":"Bierings","year":"2018","journal-title":"Br. J. Haematol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1182\/blood-2016-09-743112","article-title":"Radiation-free, alternative-donor HCT for Fanconi anemia patients: Results from a prospective multi-institutional study","volume":"129","author":"Mehta","year":"2017","journal-title":"Blood"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/s41409-020-0994-2","article-title":"FLAG-sequential regimen followed by bone marrow transplantation for myelodysplastic syndrome or acute leukemia in patients with Fanconi anemia: A Franco-Brazilian study","volume":"56","author":"Debureaux","year":"2021","journal-title":"Bone Marrow Transplant."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41409-023-02121-1","article-title":"Predictors of outcomes in hematopoietic cell transplantation for Fanconi anemia","volume":"59","author":"Cancio","year":"2024","journal-title":"Bone Marrow Transplant."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41409-023-02113-1","article-title":"T-cell depleted allogeneic hematopoietic stem cell transplant for the treatment of Fanconi anemia and MDS\/AML","volume":"59","author":"Satty","year":"2024","journal-title":"Bone Marrow Transplant."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.hoc.2009.01.008","article-title":"Fanconi Anemia","volume":"23","author":"Green","year":"2009","journal-title":"Hematol. Oncol. Clin. N. Am."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/17474086.2016.1268048","article-title":"Hematopoietic Cell Transplantation In Fanconi Anemia: Current Evidence, Challenges And Recommendations","volume":"10","author":"Ebens","year":"2017","journal-title":"Expert Rev. Hematol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"100589","DOI":"10.1016\/j.blre.2019.100589","article-title":"Genotype-Phenotype Associations in Fanconi Anemia: A Literature Review","volume":"37","author":"Giri","year":"2019","journal-title":"Blood Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/bjh.18091","article-title":"Fanconi anaemia: A syndrome with distinct subgroups","volume":"197","author":"Alter","year":"2022","journal-title":"Br. J. Haematol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s00277-020-03954-2","article-title":"Mosaicism in Fanconi anemia: Concise review and evaluation of published cases with focus on clinical course of blood count normalization","volume":"99","author":"Nicoletti","year":"2020","journal-title":"Ann. Hematol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1182\/bloodadvances.2023011888","article-title":"FANCA c.3624C>T (p.Ser1208=) is a hypomorphic splice variant associated with delayed onset of Fanconi anemia","volume":"8","author":"Tryon","year":"2024","journal-title":"Blood Adv."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/ajh.27520","article-title":"Prognostic significance of mutation type and chromosome fragility in Fanconi anemia","volume":"100","author":"Pujol","year":"2025","journal-title":"Am. J. Hematol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/bjh.18603","article-title":"Phenotypes of adults with Fanconi anaemia","volume":"201","author":"Wang","year":"2023","journal-title":"Br. J. Haematol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Merfort, L.W., Lisboa, M.d.O., Cavalli, L.R., and Bonfim, C.M.S. (2022). Cytogenetics in Fanconi Anemia: The Importance of Follow-Up and the Search for New Biomarkers of Genomic Instability. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232214119"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/ajh.25810","article-title":"Outcome of patients with Fanconi anemia developing myelodysplasia and acute leukemia who received allogeneic hematopoietic stem cell transplantation: A retrospective analysis on behalf of EBMT group","volume":"95","author":"Giardino","year":"2020","journal-title":"Am. J. Hematol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/bjh.12634","article-title":"Haematopoietic cell transplantation for acute leukaemia and advanced myelodysplastic syndrome in Fanconi anaemia","volume":"164","author":"Mitchell","year":"2014","journal-title":"Br. J. Haematol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1182\/blood.2023022273","article-title":"Does IPSS-R downstaging before transplantation improve the prognosis of patients with myelodysplastic neoplasms?","volume":"144","author":"Scheid","year":"2024","journal-title":"Blood"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1038\/s41409-024-02365-5","article-title":"Superior outcome of upfront allogeneic hematopoietic cell transplantation versus hypomethylating agent induction in myelodysplastic syndrome","volume":"59","author":"Schroeder","year":"2024","journal-title":"Bone Marrow Transplant."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Ma, J., Morimoto, K., Pulsipher, M.A., and Parekh, C. (2023). Venetoclax and Azacitidine in the Treatment of NPM1 -Mutated Donor Cell\u2013Derived Leukemia in a Patient with Fanconi Anemia: Case Report and Literature Review. JCO Precis. Oncol., e2200693.","DOI":"10.1200\/PO.22.00693"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1016\/S0140-6736(24)01880-4","article-title":"Haematopoietic gene therapy of non-conditioned patients with Fanconi anaemia-A: Results from open-label phase 1\/2 (FANCOLEN-1) and long-term clinical trials","volume":"404","author":"Zubicaray","year":"2024","journal-title":"Lancet"},{"key":"ref_27","unstructured":"Sroka, I., Frohnmayer, L., Van Ravenhorst, S., and Wirkkula, L. (2020). Fanconi Anemia Clinical Care Guidelines, Fanconi Anemia Research Fund. [5th ed.]. Available online: https:\/\/www.fanconi.org\/images\/uploads\/other\/Fanconi_Anemia_Clinical_Care_Guidelines_5thEdition_web.pdf."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1038\/s41591-019-0550-z","article-title":"Successful engraftment of gene-corrected hematopoietic stem cells in non-conditioned patients with Fanconi anemia","volume":"25","author":"Navarro","year":"2019","journal-title":"Nat. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"101094","DOI":"10.1016\/j.blre.2023.101094","article-title":"Beyond current treatment of Fanconi Anemia: What do advances in cell and gene-based approaches offer?","volume":"60","author":"Guervilly","year":"2023","journal-title":"Blood Rev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1182\/blood-2016-01-583625","article-title":"How I treat MDS and AML in Fanconi anemia","volume":"127","author":"Soulier","year":"2016","journal-title":"Blood"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1182\/blood.2023022751","article-title":"Outcomes of hematopoietic stem cell transplantation in 813 pediatric patients with Fanconi anemia","volume":"144","author":"Lum","year":"2024","journal-title":"Blood"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"532.e1","DOI":"10.1016\/j.jtct.2024.02.024","article-title":"Umbilical Cord Blood Transplantation for Fanconi Anemia with a special focus on late complications: A Study on Behalf of Eurocord and SAAWP-EBMT","volume":"30","author":"Rafii","year":"2024","journal-title":"Transplant. Cell. Ther."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1182\/blood.2021011719","article-title":"Omidubicel vs standard myeloablative umbilical cord blood transplantation: Results of a phase 3 randomized study","volume":"138","author":"Horwitz","year":"2021","journal-title":"Blood"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e228","DOI":"10.1016\/S2352-3026(22)00032-1","article-title":"Transplantation for Fanconi anaemia: Lessons learned from Brazil","volume":"9","author":"Bonfim","year":"2022","journal-title":"Lancet Haematol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1182\/blood-2006-07-036657","article-title":"Unrelated donor bone marrow transplantation for the treatment of Fanconi anemia","volume":"109","author":"Wagner","year":"2007","journal-title":"Blood"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/j.1365-2141.1980.tb07178.x","article-title":"Bone Marrow Transplantation in Fanconi Anaemia","volume":"45","author":"Gluckman","year":"1980","journal-title":"Br. J. Haematol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e367","DOI":"10.1016\/S2352-3026(15)00147-7","article-title":"Cyclophosphamide conditioning in patients with severe aplastic anaemia given unrelated marrow transplantation: A phase 1\u20132 dose de-escalation study","volume":"2","author":"Anderlini","year":"2015","journal-title":"Lancet Haematol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1365-2141.2005.05549.x","article-title":"Low-dose cyclophosphamide conditioning for haematopoietic cell transplantation from HLA-matched related donors in patients with Fanconi anaemia","volume":"130","author":"Flowers","year":"2005","journal-title":"Br. J. Haematol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41409-022-01838-9","article-title":"Fludarabine- and low-dose cyclophosphamide-based conditioning regimens provided favorable survival and engraftment for unmanipulated hematopoietic cell transplantation from unrelated donors and matched siblings in patients with Fanconi anemia: Results from the CBMTR","volume":"58","author":"Xu","year":"2023","journal-title":"Bone Marrow Transplant."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/bjh.18446","article-title":"Irradiation-free, T-cell replete haploidentical transplant for Fanconi anaemia, weighing the benefits","volume":"199","author":"Connelly","year":"2022","journal-title":"Br. J. Haematol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/bjh.18408","article-title":"Unmanipulated haploidentical haematopoietic cell transplantation with radiation-free conditioning in Fanconi anaemia: A retrospective analysis from the Chinese Blood and Marrow Transplantation Registry Group","volume":"199","author":"Xu","year":"2022","journal-title":"Br. J. Haematol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1182\/blood-2023-189664","article-title":"Hematopoietic Stem Cell Transplantation for Fanconi Anemia: Outcome and Prognostic Factors for Survival and Subsequent Neoplasms","volume":"142","author":"Rotz","year":"2023","journal-title":"Blood"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1016\/j.bbmt.2020.08.019","article-title":"Haploidentical Stem Cell Transplantation with Post-Transplant Cyclophosphamide in Fanconi Anemia: Improving Outcomes with Improved Supportive Care in India","volume":"26","author":"Uppuluri","year":"2020","journal-title":"Biol. Blood Marrow Transplant."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.4081\/pr.2011.s2.e15","article-title":"Nonmyeloablative, HLA-haploidentical bone marrow transplantation with high dose, post-transplantation cyclophosphamide","volume":"3","author":"Munchel","year":"2011","journal-title":"Pediatr. Rep."},{"key":"ref_45","first-page":"95","article-title":"Haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide for Fanconi anemia with\/without anti-thymocyte globulin","volume":"7","author":"Uppuluri","year":"2024","journal-title":"Blood Cell Ther."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/bmt.2012.237","article-title":"Increased apoptosis is linked to severe acute GVHD in patients with Fanconi anemia","volume":"48","author":"Wang","year":"2013","journal-title":"Bone Marrow Transplant."},{"key":"ref_47","first-page":"S488","article-title":"Reducing Ptcy Dose in Patients Receiving CAST for GvHD Prevention Results in Accelerated Engraftment at the Cost of Higher Incidence of GvHD","volume":"30","author":"Londono","year":"2024","journal-title":"Transplant. Cell. Ther. Off. Publ. Am. Soc. Transplant. Cell. Ther."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1182\/bloodadvances.2022008545","article-title":"Abatacept GVHD prophylaxis in unrelated hematopoietic cell transplantation for pediatric bone marrow failure","volume":"7","author":"Stenger","year":"2023","journal-title":"Blood Adv."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3604","DOI":"10.1182\/bloodadvances.2023010545","article-title":"PTCy, abatacept, and a short course of tacrolimus for GVHD prevention after haploidentical transplantation","volume":"7","author":"Cirrone","year":"2023","journal-title":"Blood Adv."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1200\/JCO.20.01086","article-title":"Phase II Trial of Costimulation Blockade with Abatacept for Prevention of Acute GVHD","volume":"39","author":"Watkins","year":"2021","journal-title":"J. Clin. Oncol."},{"key":"ref_51","first-page":"605.e1","article-title":"Long Term Follow-Up Of Abatacept, Post-Transplantation Cyclophosphamide and Sirolimus (AbaCyS) based Haploidentical Transplantation in Younger Patients with Nonmalignant Diseases","volume":"30","author":"Jaiswal","year":"2024","journal-title":"Transplant. Cell. Ther. Off. Publ. Am. Soc. Transplant. Cell. Ther."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1182\/bloodadvances.2020003707","article-title":"HLA-haploidentical TCR\u03b1\u03b2+\/CD19+-depleted stem cell transplantation in children and young adults with Fanconi anemia","volume":"5","author":"Strocchio","year":"2021","journal-title":"Blood Adv."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1182\/blood-2022-163140","article-title":"Outcome of Haematopoietic Cell Transplantation in 813 Children with Fanconi Anaemia: A Study on Behalf of the EBMT Severe Aplastic Anaemia Working Party and Paediatric Disease Working Party","volume":"140","author":"Lum","year":"2022","journal-title":"Blood"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/ajh.26135","article-title":"Haplo-identical or mismatched unrelated donor hematopoietic cell transplantation for Fanconi anemia: Results from the Severe Aplastic Anemia Working Party of the EBMT","volume":"96","author":"Zubicaray","year":"2021","journal-title":"Am. J. Hematol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e111","DOI":"10.1016\/S2352-3026(21)00375-6","article-title":"Individualised dosing of anti-thymocyte globulin in paediatric unrelated allogeneic haematopoietic stem-cell transplantation (PARACHUTE): A single-arm, phase 2 clinical trial","volume":"9","author":"Admiraal","year":"2022","journal-title":"Lancet Haematol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/s41409-024-02266-7","article-title":"Addition of ruxolitinib to standard graft-versus-host disease prophylaxis for allogeneic stem cell transplantation in aplastic anemia patients","volume":"59","author":"Zhang","year":"2024","journal-title":"Bone Marrow Transplant."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1002\/ajh.27293","article-title":"HLA-haploidentical stem cell transplantation in children with inherited bone marrow failure syndromes: A retrospective analysis on behalf of EBMT severe aplastic Anemia and pediatric diseases working parties","volume":"99","author":"Giardino","year":"2024","journal-title":"Am. J. Hematol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3324\/haematol.2017.178111","article-title":"Cancer in the National Cancer Institute inherited bone marrow failure syndrome cohort after fifteen years of follow-up","volume":"103","author":"Alter","year":"2018","journal-title":"Haematologica"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/bmt.2016.32","article-title":"Late effects in patients with Fanconi anemia following allogeneic hematopoietic stem cell transplantation from alternative donors","volume":"51","author":"Anur","year":"2016","journal-title":"Bone Marrow Transplant."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"4279","DOI":"10.1182\/blood-2013-01-479733","article-title":"Allogeneic hematopoietic stem cell transplantation in Fanconi anemia: The European Group for Blood and Marrow Transplantation experience","volume":"122","author":"Porcher","year":"2013","journal-title":"Blood"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1001\/archotol.129.1.106","article-title":"High incidence of head and neck squamous cell carcinoma in patients with Fanconi anemia","volume":"129","author":"Kutler","year":"2003","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"5168","DOI":"10.1158\/1078-0432.CCR-21-1259","article-title":"Treatment of Fanconi Anemia\u2013Associated Head and Neck Cancer: Opportunities to Improve Outcomes","volume":"27","author":"Lee","year":"2021","journal-title":"Clin. Cancer Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"104816","DOI":"10.1016\/j.oraloncology.2020.104816","article-title":"Management of Fanconi Anemia patients with head and neck carcinoma: Diagnosis and treatment adaptation","volume":"108","author":"Beddok","year":"2020","journal-title":"Oral Oncol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.jds.2023.06.001","article-title":"The onset and progression of oral potentially malignant disorders in Fanconi anemia patients: Highlighting early detection of oral cancer","volume":"19","author":"Long","year":"2024","journal-title":"J. Dent. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1182\/blood-2023-178400","article-title":"Radiation and Busulfan-Free Hematopoietic Stem Cell Transplantation Using Briquilimab (JSP191) Anti-CD117 Antibody-Conditioning, Transient Immunosuppression and TCR\u03b1\u03b2+ T-Cell\/CD19+ B-Cell Depleted Haploidentical Grafts in Patients with Fanconi Anemia","volume":"142","author":"Agarwal","year":"2023","journal-title":"Blood"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1182\/blood.2023023549","article-title":"Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate conditioned Fanconi anemia mice","volume":"143","author":"Saha","year":"2024","journal-title":"Blood"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1182\/bloodadvances.2023011625","article-title":"Single-center randomized trial of T-reg graft alone vs T-reg graft plus tacrolimus for the prevention of acute GVHD","volume":"8","author":"Bader","year":"2024","journal-title":"Blood Adv."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1182\/hematology.2023000489","article-title":"Management of Fanconi anemia beyond childhood","volume":"2023","author":"Olson","year":"2023","journal-title":"Hematology"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41409-023-02133-x","article-title":"Hematopoietic stem cell transplantation in patients with Fanconi anemia: A report of late effects and psychosocial adjustment in life","volume":"59","author":"Ayas","year":"2024","journal-title":"Bone Marrow Transplant."}],"container-title":["Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-9721\/13\/7\/195\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:58:27Z","timestamp":1760032707000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-9721\/13\/7\/195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,25]]},"references-count":69,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["diseases13070195"],"URL":"https:\/\/doi.org\/10.3390\/diseases13070195","relation":{},"ISSN":["2079-9721"],"issn-type":[{"value":"2079-9721","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,25]]}}}