{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:31:32Z","timestamp":1760059892521,"version":"build-2065373602"},"reference-count":73,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>Background: Cutaneous lichen planus (CLP) is a chronic inflammatory T cell-mediated disease driven by a mixed Th1 and Th2 lymphocyte population, for which many of the currently available treatments have poor efficacy. Aim: The aim of this study was to indicate the clinical success of dupilumab administration after two years of treatment in a case of longstanding CLP and to perform a review of the medical literature related to the use of dupilumab in different dermatologic settings and in CLP. Case presentation: One 26-year-old woman with a previous history of atopic dermatitis had a long-lasting skin condition, referred to as a suspected lichen, which started when she was 7 years old. Her disease exhibited a relapsing\u2013remitting course with severe bouts of pruritus over a very long period. The final histological diagnosis of CLP was confirmed at the age of 26. Starting dupilumab (injected subcutaneously at a dose of 600 mg followed by a maintenance dose of 300 mg every two weeks) resolved the skin scenery of this patient, who is currently in full remission. Conclusions: The remarkable recovery from CLP obtained via treatment with dupilumab in this single-patient case study emphasizes the potential therapeutic implications of targeting the Th2 pathway in this skin disorder.<\/jats:p>","DOI":"10.3390\/diseases13070225","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T10:10:38Z","timestamp":1752833438000},"page":"225","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Dupilumab in a Young Woman with Refractory Cutaneous Lichen Planus: A Case-Based Review"],"prefix":"10.3390","volume":"13","author":[{"given":"Cristina","family":"Guerriero","sequence":"first","affiliation":[{"name":"Unit of Dermatology, Dipartimento Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A.Gemelli IRCCS, 00168 Rome, Italy"},{"name":"Dipartimento Universitario di Medicina e Chirurgia Traslazionale, Universit\u00e0 Cattolica Sacro Cuore, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1290-0474","authenticated-orcid":false,"given":"Luisa","family":"Boeti","sequence":"additional","affiliation":[{"name":"Unit of Dermatology, Dipartimento Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A.Gemelli IRCCS, 00168 Rome, Italy"},{"name":"Dipartimento Universitario di Medicina e Chirurgia Traslazionale, Universit\u00e0 Cattolica Sacro Cuore, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0628-1312","authenticated-orcid":false,"given":"Francesco","family":"Mastellone","sequence":"additional","affiliation":[{"name":"Department of Life Sciences and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Coscarella","sequence":"additional","affiliation":[{"name":"Unit of Dermatology, Dipartimento Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A.Gemelli IRCCS, 00168 Rome, Italy"},{"name":"Dipartimento Universitario di Medicina e Chirurgia Traslazionale, Universit\u00e0 Cattolica Sacro Cuore, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gennaro Marco","family":"Falco","sequence":"additional","affiliation":[{"name":"Unit of Dermatology, Dipartimento Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A.Gemelli IRCCS, 00168 Rome, Italy"},{"name":"Dipartimento Universitario di Medicina e Chirurgia Traslazionale, Universit\u00e0 Cattolica Sacro Cuore, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerardo","family":"Palmisano","sequence":"additional","affiliation":[{"name":"Unit of Dermatology, Dipartimento Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A.Gemelli IRCCS, 00168 Rome, Italy"},{"name":"Dipartimento Universitario di Medicina e Chirurgia Traslazionale, Universit\u00e0 Cattolica Sacro Cuore, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Pelanda","sequence":"additional","affiliation":[{"name":"Department of Life Sciences and Public Health, Fondazione Policlinico Universitario A. 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