{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T20:42:22Z","timestamp":1780605742711,"version":"3.54.1"},"reference-count":18,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>Background\/Objectives: Acetazolamide is widely used for acute mountain sickness (AMS) prophylaxis. Whilst generally safe, acute kidney injury (AKI) is a rare but serious adverse event. We present a case of anuric AKI following minimal exposure to acetazolamide, contributing to the limited literature on its nephrotoxicity at prophylactic doses. Methods: A 54-year-old previously healthy male ingested 250 mg\/day of oral acetazolamide for two days. He developed acute anuria and lumbar pain. Diagnostic evaluation included laboratory tests, imaging, microbiological cultures, autoimmune panels, and diuretic response. No signs of infection, urinary tract obstruction, or systemic disease were found. Results: The patient met KDIGO 2012 criteria for stage 3 AKI, with peak serum creatinine of 10.6 mg\/dL and metabolic acidosis. Imaging confirmed non-obstructive nephrolithiasis. Conservative treatment failed; intermittent hemodialysis was initiated. Renal function recovered rapidly, with the normalization of serum creatinine and urinary output by day 4. Conclusions: This case represents the lowest cumulative dose of acetazolamide reported to cause stage 3 AKI. The findings support a pathophysiological mechanism involving sulfonamide-induced crystalluria and intratubular obstruction. Physicians should consider acetazolamide in the differential diagnosis of AKI, even with short-term prophylactic use.<\/jats:p>","DOI":"10.3390\/diseases13070228","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T08:47:14Z","timestamp":1753087634000},"page":"228","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An Unusual Case of Anuric Acute Kidney Injury Secondary to the Use of Low-Dose Acetazolamide as Preventive Management for Acute Mountain Sickness"],"prefix":"10.3390","volume":"13","author":[{"given":"Marco","family":"Dominguez Davalos","sequence":"first","affiliation":[{"name":"Department of Nephrology, Hospital Cayetano Heredia, Lima 15002, Peru"},{"name":"Faculty of Medicine, Peruana Cayetano Heredia University, Lima 15002, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"Valenzuela C\u00f3rdova","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital Cayetano Heredia, Lima 15002, Peru"},{"name":"Faculty of Medicine, Peruana Cayetano Heredia University, Lima 15002, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Rodr\u00edguez Tudero","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital Universitario de Salamanca, 37007 Salamanca, Spain"},{"name":"Surgery Department, Faculty of Medicine, University of Salamanca, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3005-7039","authenticated-orcid":false,"given":"Elena","family":"Jim\u00e9nez Mayor","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital San Pedro de Alc\u00e1ntara, 10001 C\u00e1ceres, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5098-944X","authenticated-orcid":false,"given":"Carlos Bedia","family":"Castillo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Peruana Cayetano Heredia University, Lima 15002, Peru"},{"name":"Department of Rheumatology, Hospital Cayetano Heredia, Lima 15002, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9346-2279","authenticated-orcid":false,"given":"Jos\u00e9 C.","family":"De La Flor","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital Central Defense Gomez Ulla, 28047 Madrid, Spain"},{"name":"Health Sciences Doctoral Program, Faculty of Medicine, Alcala University, 28805 Madrid, Spain"},{"name":"Department of Medicine and Medical Specialties, Faculty of Medicine, Alcala University, 28805 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Leon Montesinos","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University Clinical Hospital, La Paz 0201, Bolivia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9093-6093","authenticated-orcid":false,"given":"Cristian","family":"Le\u00f3n Rabanal","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hospital Cayetano Heredia, Lima 15002, Peru"},{"name":"Faculty of Medicine, Peruana Cayetano Heredia University, Lima 15002, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6558-7231","authenticated-orcid":false,"given":"Michael","family":"Cieza Terrones","sequence":"additional","affiliation":[{"name":"Department of Engineering, Faculty of Science and Engineering, Peruana Cayetano Heredia University, Lima 15002, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier A.","family":"Neyra","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Nephrology, Bone and Mineral Metabolism, University of Kentucky, Lexington, KY 40508, USA"},{"name":"Charles and Jane Park Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX 75080, USA"},{"name":"Department of Internal Medicine, Division of Nephrology, University of Alabama at Birmingham, Birmingham, AL 35250, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.2174\/138161208783877866","article-title":"The development of topically acting carbonic anhydrase inhibitors as antiglaucoma agents","volume":"14","author":"Mincione","year":"2008","journal-title":"Curr. 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