{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T10:40:17Z","timestamp":1760006417074,"version":"build-2065373602"},"reference-count":54,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>Background\/Objectives: There are very few publications on unplanned excisions of great saphenous vein leiomyosarcomas (GSV-LMS), and their impact on the prognosis of the disease is not well known. The objective of this study is to present a series of nine new leiomyosarcomas of the great saphena vein (LMS-GSV) cases, with the aim of increasing diagnostic awareness and proposing guidelines for therapeutic management. Methods: This is a prospective single-centre study of a series of nine GSV-LMS in thigh (stage IIIA AJCC), knee and proximal leg (IB, 1 II and 3 IIIA), and ankle (2 IIIB and 1 II). Eight patients were female, and the mean age was 72 years. All patients were surgically treated. Five (56%) were unplanned excisions. All these patients were reoperated on to attempt wide resection margins. In a patient, an infra-patellar amputation was performed. Another amputation was refused by another patient. Eight patients received adjuvant radiotherapy. Results: One patient died 8 years after amputation for a reason other than LMS. The patient who refused amputation has been alive, disease-free, for 28 months. The mean follow-up of surviving patients was 39 months (6\u201378 months). In these patients, there were no local recurrences or metastases. The mean functional outcome according to the MSTS score was 28.9 (range: 24\u201330). Conclusions: Unplanned excision of GSV-LMS can be prevented through clinical and imaging suspicion. Surgery and re-excision in case of inadequate previous margins and adjuvant radiotherapy lead to a good oncological and functional outcome.<\/jats:p>","DOI":"10.3390\/diseases13100330","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T11:42:49Z","timestamp":1759750969000},"page":"330","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Leiomyosarcomas of the Great Saphenous Vein: Diagnostic and Therapeutic Strategies to Prevent Unplanned Excisions and Improve Oncologic, Functional, and Psychological Outcomes"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8038-278X","authenticated-orcid":false,"given":"Luis R.","family":"Ramos Pascua","sequence":"first","affiliation":[{"name":"Department of Trauma and Orthopaedics Surgery, University Hospital 12 de Octubre, Av\/C\u00f3rdoba, s\/n, Usera, 28041 Madrid, Spain"},{"name":"School of Medicine, Complutense University, Pl. de Ram\u00f3n y Cajal, s\/n, Moncloa-Aravaca, 28040 Madrid, Spain"},{"name":"Department of Trauma and Orthopaedics Surgery, University Hospital Quir\u00f3nsalud, C\/Diego de Vel\u00e1zquez, 1, Pozuelo de Alarc\u00f3n, 28223 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Ramos Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Hospital General Universitario Nuestra Se\u00f1ora del Prado, Ctra\/Madrid-Extremadura, Km 114, s\/n, 45600 Talavera de la Reina, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Robustillo Rego","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, University Hospital 12 de Octubre, Av\/C\u00f3rdoba, s\/n, Usera, 28041 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Violeta Gonz\u00e1lez","family":"M\u00e9ndez","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital 12 de Octubre, Av\/C\u00f3rdoba, s\/n, Usera, 28041 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Bel\u00e9n","family":"Enguita Valls","sequence":"additional","affiliation":[{"name":"School of Medicine, Complutense University, Pl. de Ram\u00f3n y Cajal, s\/n, Moncloa-Aravaca, 28040 Madrid, Spain"},{"name":"Department of Pathology, University Hospital 12 de Octubre, Av\/C\u00f3rdoba, s\/n, Usera, 28041 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda I.","family":"Mora Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Trauma and Orthopaedic Surgery, University Hospital of Burgos, Av. Islas Baleares, 3, 09006 Burgos, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1171-1508","authenticated-orcid":false,"given":"Gabriel","family":"Rubio Valladolid","sequence":"additional","affiliation":[{"name":"School of Medicine, Complutense University, Pl. de Ram\u00f3n y Cajal, s\/n, Moncloa-Aravaca, 28040 Madrid, Spain"},{"name":"Department of Psychiatry, University Hospital 12 de Octubre, Av\/C\u00f3rdoba, s\/n, Usera, 28041 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas E.","family":"Vil\u00e1 y Rico","sequence":"additional","affiliation":[{"name":"Department of Trauma and Orthopaedics Surgery, University Hospital 12 de Octubre, Av\/C\u00f3rdoba, s\/n, Usera, 28041 Madrid, Spain"},{"name":"School of Medicine, Complutense University, Pl. de Ram\u00f3n y Cajal, s\/n, Moncloa-Aravaca, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"key":"ref_1","unstructured":"Testut, L., and Latarjet, A. 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