{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:10:44Z","timestamp":1791598244863,"version":"4.3.4"},"reference-count":55,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>Background\/Objectives: Epidermoid cysts are benign lesions originating from germinative epithelium, characterized by a keratin-filled cavity. They are histopathologically classified as epidermoid, dermoid, or teratoid. Intraoral cases are exceedingly rare, comprising less than 0.01% of all oral cystic lesions, most frequently affecting the floor of the mouth. While usually asymptomatic, they may become painful due to infection or growth. Because of their rarity in sites such as the upper lip, they may be clinically misdiagnosed, making awareness crucial for accurate management. Methods: Diagnosis is primarily clinical and histopathological, with imaging reserved for complex or deep-seated lesions. Complete surgical excision is the standard treatment to prevent recurrence. In this case, diagnostic evaluation included careful clinical inspection, assessment of consistency and mobility, and excisional biopsy with subsequent histopathological confirmation. Results: We report a rare case of a 68-year-old female presenting with a painless, slow-growing swelling of the upper lip. Clinical examination revealed a solitary, whitish, mobile lesion. Histopathological analysis confirmed an epidermoid cyst. The lesion was surgically excised under local anesthesia, with no recurrence observed at six-month follow-up. The outcome highlights the success of surgical management and the importance of monitoring even when the lesion appears benign. Conclusions: Although uncommon in the upper lip, epidermoid cysts should be considered in the differential diagnosis of submucosal swellings. Complete surgical excision offers a favorable outcome and prevents recurrence. Reporting such rare presentations expands clinical awareness and assists in differentiating these lesions from other pathologies of the oral cavity.<\/jats:p>","DOI":"10.3390\/diseases13110358","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T13:19:29Z","timestamp":1762348769000},"page":"358","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intraoral Epidermoid Cyst: Case Report and Literature Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8369-1024","authenticated-orcid":false,"given":"Ana","family":"Andabak Rogulj","sequence":"first","affiliation":[{"name":"Department of Oral Medicine, University of Zagreb School of Dental Medicine, 10000 Zagreb, Croatia"},{"name":"Clinical Department of Oral Diseases, Dental Clinic, University Hospital Centre (UHC) Zagreb, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7391-6114","authenticated-orcid":false,"given":"Danica","family":"Vidovi\u0107 Juras","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, University of Zagreb School of Dental Medicine, 10000 Zagreb, Croatia"},{"name":"Clinical Department of Oral Diseases, Dental Clinic, University Hospital Centre (UHC) Zagreb, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6096-6796","authenticated-orcid":false,"given":"Bo\u017eana","family":"Lon\u010dar Brzak","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, University of Zagreb School of Dental Medicine, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8076-7591","authenticated-orcid":false,"given":"Ivana","family":"\u0160krinjar","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, University of Zagreb School of Dental Medicine, 10000 Zagreb, Croatia"},{"name":"Clinical Department of Oral Diseases, Dental Clinic, University Hospital Centre (UHC) Zagreb, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2545-4474","authenticated-orcid":false,"given":"Bruno","family":"\u0160piljak","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, University of Zagreb School of Dental Medicine, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5894-419X","authenticated-orcid":false,"given":"Sven","family":"Seiwerth","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"400","DOI":"10.61386\/imj.v14i3.42","article-title":"Submental epidermoid cyst masquerading as a giant plunging ranula: A case report and review of literature","volume":"14","author":"Eziagu","year":"2021","journal-title":"Ibom Med. 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