{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:15:28Z","timestamp":1779297328166,"version":"3.51.4"},"reference-count":58,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:00:00Z","timestamp":1762560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>Background: Complicated pneumonia (CP) in children presents in various forms\u2014including empyema, necrotizing pneumonia (NP), necrotizing pneumonia with pleural effusion (NP + PE), and parapneumonic pleural effusion (PPE)\u2014and is associated with significant morbidity despite advances in antimicrobial therapy. This study aimed to describe and compare the clinical characteristics, laboratory findings, antibiotic use, and outcomes across different CP subtypes in hospitalized children and to assess the impact of prior antibiotic use on presentation and treatment outcomes. Methods: This retrospective observational study included 58 children admitted with CP to tertiary hospitals in Jordan. Patients were categorized into four subtypes: empyema (n = 4), NP (n = 4), NP + PE (n = 17), and PPE (n = 33). Demographic data, clinical features, laboratory results, antibiotic regimens, and clinical outcomes were analyzed. Multivariable regression was used to identify predictors of prior antibiotic use. Results: Fever and cough were the most common symptoms (96.6%). Over 40% of patients had received antibiotics prior to admission. Those pre-treated had significantly longer symptom duration (8.2 vs. 4.5 days, p &lt; 0.001), longer hospitalization (18.2 vs. 14.6 days, p = 0.023), and more frequent chest tube insertion (66.7% vs. 35.3%, p = 0.019). Streptococcus pneumoniae was the most common organism isolated in culture-positive cases. Vancomycin-based regimens were the most frequently used treatments. Univariate regression analysis showed that patients with prior antibiotic use had significantly higher odds of longer hospitalization duration (OR = 1.11, p = 0.028) and chest tube insertion (OR = 3.67, p = 0.021). Conclusions: Complicated pneumonia in children remains a diverse and clinically significant condition. The findings demonstrate that prolonged symptom duration prior to hospitalization and certain clinical interventions were associated with prior antibiotic exposure. These results provide insight into local disease patterns and prescribing behaviors, which may help inform strategies to optimize antimicrobial stewardship and improve care pathways for affected children.<\/jats:p>","DOI":"10.3390\/diseases13110364","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T11:47:27Z","timestamp":1762775247000},"page":"364","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical Profiles, Management, and Outcomes of Complicated Pneumonia in Children: A Retrospective Study from Tertiary Centers in Jordan"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4832-5149","authenticated-orcid":false,"given":"Lina","family":"Alshadfan","sequence":"first","affiliation":[{"name":"Pediatrics and Pediatric Pulmonology, Department of Pediatrics, Faculty of Medicine, Al Balqa Applied University, Al-Salt P.O. Box 19117, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muna","family":"Kilani","sequence":"additional","affiliation":[{"name":"Pediatrics and Pediatric Pulmonology, Department of Pediatrics, Faculty of Medicine, The Hashemite University, Zarqa P.O. Box 13133, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3243-9007","authenticated-orcid":false,"given":"Saleh","family":"Abualhaj","sequence":"additional","affiliation":[{"name":"General Surgery Department, Faculty of Medicine, Al-Balqa Applied University, Al-Salt P.O. Box 19117, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osama","family":"Abu-Salah","sequence":"additional","affiliation":[{"name":"Pediatrics, Department of Pediatrics, Faculty of Medicine, Al Balqa Applied University, Al-Salt P.O. Box 19117, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6197-3273","authenticated-orcid":false,"given":"Mohammad Ghassab","family":"Deameh","sequence":"additional","affiliation":[{"name":"Prince Hamzah Hospital, Amman P.O. Box 11947, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3748-6933","authenticated-orcid":false,"given":"Ahmad Nidal","family":"Al-Faouri","sequence":"additional","affiliation":[{"name":"Prince Hamzah Hospital, Amman P.O. Box 11947, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Elayyan","sequence":"additional","affiliation":[{"name":"Prince Hamzah Hospital, Amman P.O. Box 11947, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randa","family":"Othman","sequence":"additional","affiliation":[{"name":"Pediatrics, Department of Pediatrics, Faculty of Medicine, Al Balqa Applied University, Al-Salt P.O. Box 19117, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reem","family":"Abuzraiq","sequence":"additional","affiliation":[{"name":"Pediatrics, Department of Pediatrics, Faculty of Medicine, Al Balqa Applied University, Al-Salt P.O. Box 19117, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1097\/INF.0b013e31823883be","article-title":"Comparative Dynamics, Morbidity and Mortality Burden of Pediatric Viral Respiratory Infections in an Equatorial City","volume":"31","author":"Alonso","year":"2012","journal-title":"Pediatr. Infect. Dis. 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