{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T10:26:16Z","timestamp":1763029576503,"version":"3.45.0"},"reference-count":23,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>Background: Central precocious puberty (CPP) is diagnosed through a combination of clinical, auxological, and biochemical parameters, with pharmacological stimulation tests considered the diagnostic gold standard. In recent years, triptorelin, a long-acting Gonadotropin-Releasing Hormone (GnRH) analog, has been increasingly adopted in clinical practice due to limited availability of native GnRH. Objective: To compare the clinical, auxological, and hormonal profiles of girls diagnosed with idiopathic CPP using either the classical GnRH stimulation test or the triptorelin test. Methods: This retrospective study included 136 female patients diagnosed with CPP and followed for at least two years at a single pediatric endocrinology unit. Of these, 101 underwent a GnRH stimulation test, and 35 were assessed using the triptorelin test. Baseline and stimulated hormonal parameters, growth data, and IGF-1 levels were collected. A multivariate linear regression model was used to explore the influence of age, test type, and other covariates on the LH peak response. Results: Anthropometric and baseline hormonal parameters were comparable between the two groups. The LH peak was significantly higher in the GnRH group (9.8 \u00b1 3.1 IU\/L at 60 min) than in the triptorelin group (6.8 \u00b1 2.4 IU\/L at 4 h). FSH levels were also significantly lower following triptorelin stimulation (p = 0.004), while the LH\/FSH ratio did not differ significantly. Multivariate analysis confirmed that triptorelin was associated with a lower LH peak (\u03b2 = \u22122.2, p = 0.008), particularly in younger patients, with a significant interaction between age and test type (\u03b2 = 0.6, p = 0.022). Conclusions: Both GnRH and triptorelin stimulation tests are valid tools for CPP diagnosis. However, the GnRH test appears to elicit a more robust LH response, especially in younger patients, whereas the triptorelin test is associated with delayed and lower LH peaks.<\/jats:p>","DOI":"10.3390\/diseases13110370","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T09:59:09Z","timestamp":1763027949000},"page":"370","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Diagnostic Utility of the Triptorelin Stimulation Test Compared to the Standard Gonadotropin-Releasing Hormone Stimulation Test in Children with Idiopathic Central Precocious Puberty"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3711-4928","authenticated-orcid":false,"given":"Giorgio","family":"Sodero","sequence":"first","affiliation":[{"name":"Pediatric Unit, Perrino Hospital, 72100 Brindisi, Italy"},{"name":"Pediatric Endocrinology Unit, Perrino Hospital, 72100 Brindisi, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2478\/abm-2025-0009","article-title":"Precocious puberty: A comprehensive review of diagnosis and clinical presentation, etiology, and treatment","volume":"19","author":"Srilanchakon","year":"2025","journal-title":"Asian Biomed."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.eprac.2025.03.004","article-title":"Early-life risks of central precocious puberty","volume":"31","author":"Yin","year":"2025","journal-title":"Endocr. 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