{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:29:22Z","timestamp":1792794562256,"version":"4.5.0"},"reference-count":18,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T00:00:00Z","timestamp":1765584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>Introduction: Although patients with upper gastrointestinal (GI) cancer have an increased risk of developing small intestinal bacterial overgrowth (SIBO) due to disease- and treatment-related factors, SIBO remains underdiagnosed in oncology. Aim and Methods: This prospective study evaluated the prevalence of SIBO and its impact on symptom-related quality of life (QoL) in patients with current or prior upper GI cancer. Between April 2021 and May 2022, patients reporting SIBO-related symptoms like bloating and\/or diarrhea completed a standardized symptom questionnaire. QoL impact was scored from 0 (none) to 3 (severe). Patients with scores &gt; 1 and no recent antibiotic use underwent upper endoscopy with duodenal aspirate. SIBO was defined as &gt;103 CFU\/mL. Results: Ninety patients were enrolled (51% female; median age of 65 years): 35% had pancreatic, 34% gastric, 17% biliary, and 14% esophageal cancer. Sixty reported SIBO-related symptoms: 35% reported bloating, 11% diarrhea, and 54% both. Of these, 36 underwent endoscopy; 53% were diagnosed with SIBO. Among SIBO-positive patients, 95% reported bloating and 58% reported diarrhea. Prior abdominal surgery was recorded in 63% of SIBO cases. Conclusions: SIBO was identified in more than half of symptomatic upper GI cancer patients, with a strong association with bloating and previous abdominal surgery. These findings emphasize the importance of clinical awareness and appropriate diagnostic evaluation for SIBO in this high-risk group to improve symptom control and quality of life.<\/jats:p>","DOI":"10.3390\/diseases13120398","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T13:32:37Z","timestamp":1765805557000},"page":"398","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence and Impact on Quality of Life of Small Intestinal Bacterial Overgrowth (SIBO)-Related Symptoms in Patients with Upper Gastrointestinal Cancer"],"prefix":"10.3390","volume":"13","author":[{"given":"Rosa","family":"Rosania","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Infectious Disease, Otto von Guericke University Hospital, 39120 Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6659-6738","authenticated-orcid":false,"given":"Achim J.","family":"Kaasch","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Medical Microbiology and Hospital Hygiene, Otto-Von Guericke University Magdeburg, 39120 Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Bose","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Infectious Disease, Otto von Guericke University Hospital, 39120 Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0524-8833","authenticated-orcid":false,"given":"Friedrich","family":"Sinner","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Infectious Disease, Otto von Guericke University Hospital, 39120 Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6881-1817","authenticated-orcid":false,"given":"Christian","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Infectious Disease, Otto von Guericke University Hospital, 39120 Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Weigt","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Infectious Disease, Otto von Guericke University Hospital, 39120 Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Keitel","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Infectious Disease, Otto von Guericke University Hospital, 39120 Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8581-0974","authenticated-orcid":false,"given":"Marino","family":"Venerito","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Infectious Disease, Otto von Guericke University Hospital, 39120 Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/nmo.12516","article-title":"Small intestinal bacterial overgrowth: Duodenal aspiration vs. glucose breath test","volume":"27","author":"Erdogan","year":"2015","journal-title":"Neurogastroenterol. 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