{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T20:24:21Z","timestamp":1788639861636,"version":"build-2803163510"},"reference-count":44,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2022-00651"],"award-info":[{"award-number":["2022-00651"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>Background\/Objectives: Published prevalences of depression are mainly based on measurements of depressive symptoms, whereas data on clinical depressions are lacking. Our aim was to map the prevalence of ICD-10 diagnoses of depression made by physicians in routine healthcare, during the last year of life in non-cancer conditions and to study associations with clinical variables. Methods: A registry study on all persons in ordinary accommodation, dying in 2015\u20132023 in non-cancer conditions. Results: Of 62,228 persons dying from non-cancer conditions, 4391 (7.1%) were formally diagnosed with depression during the last year in life. Depression was significantly more common in women than in men, 8.0% vs. 6.3% (p &lt; 0.001); adjusted odds ratio (aOR) 1.46 (95%CI 1.37\u20131.55). Prevalence of depression was highest in persons 18\u201344 years (18.3%) and lowest in persons &gt;85 years old (5.7%) (p &lt; 0.001); aOR 4.12 (95%CI 3.66\u20134.63). It was also more common in persons living in more affluent areas, aOR 1.19 (95%CI 1.10\u20131.29). The condition was most frequent in persons with Parkinson\u2019s disease (9.4%) and COPD (8.2%). Depression was associated with more emergency room visits, 89.5% vs. 81.3% (p &lt; 0.001), and visits in psychiatric services in the last year in life, 41.4% vs. 8.8% (p &lt; 0.001). Depression was less prevalent in persons admitted to palliative care (p = 0.007). Conclusions: The highest frequencies were found in women, younger persons, and those living in affluent areas, but also in certain diagnoses such as Parkinson\u2019s disease and COPD. Clinical depression in the last year of life is associated with more emergency room visits and utilization of psychiatric services.<\/jats:p>","DOI":"10.3390\/diseases14010009","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T08:47:27Z","timestamp":1766998047000},"page":"9","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Depression in the Last Year in Life in Persons Dying from Non-Cancer Conditions\u2014Real World Data"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8514-5433","authenticated-orcid":false,"given":"Peter","family":"Strang","sequence":"first","affiliation":[{"name":"Department of Oncology-Pathology, Karolinska Institutet, SE 171 77 Stockholm, Sweden"},{"name":"Palliative Medicine and R&D Unit, Stockholms Sjukhem, SE 112 19 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2711-0245","authenticated-orcid":false,"given":"Anette","family":"Alvariza","sequence":"additional","affiliation":[{"name":"Palliative Medicine and R&D Unit, Stockholms Sjukhem, SE 112 19 Stockholm, Sweden"},{"name":"Department of Health Care Sciences, Marie Cederschi\u00f6ld University, P.O. BOX 11189, SE 100 61 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1619-4965","authenticated-orcid":false,"given":"Torbj\u00f6rn","family":"Schultz","sequence":"additional","affiliation":[{"name":"Palliative Medicine and R&D Unit, Stockholms Sjukhem, SE 112 19 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3505-9283","authenticated-orcid":false,"given":"Linda","family":"Bj\u00f6rkhem-Bergman","sequence":"additional","affiliation":[{"name":"Palliative Medicine and R&D Unit, Stockholms Sjukhem, SE 112 19 Stockholm, Sweden"},{"name":"Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, SE 141 83 Huddinge, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S1470-2045(01)00456-9","article-title":"Depression in cancer patients","volume":"2","author":"Chochinov","year":"2001","journal-title":"Lancet Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S1470-2045(11)70002-X","article-title":"Prevalence of depression, anxiety, and adjustment disorder in oncological, haematological, and palliative-care settings: A meta-analysis of 94 interview-based studies","volume":"12","author":"Mitchell","year":"2011","journal-title":"Lancet Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/SPC.0b013e328326b59b","article-title":"The detection of depression in palliative care","volume":"3","author":"Rayner","year":"2009","journal-title":"Curr. 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