{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T21:38:17Z","timestamp":1784842697106,"version":"3.55.0"},"reference-count":53,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan","award":["BR28713159"],"award-info":[{"award-number":["BR28713159"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>Background: Chronically non-healing thoracic wounds after cardiac and non-cardiac thoracotomy, including cases when coronary artery bypass grafting (CABG) is performed, represent a great clinical challenge. It is often that a conservative treatment of the wounds does not provide effective regeneration of the damaged tissues. It is especially critical in patients with infected wounds, in patients owning a systemic infection, and in elderly people. Methods: The article presents a case report of successful treatment of a 63-year-old man with refractory chronic osteomyelitis of the sternum and mediastinitis four years after CABG, complicated by COVID-19 at the time of reconstructive surgery. Due to the low effectiveness of conservative treatment methods, a two-stage approach was applied: radical surgical wound debridement followed by infiltration of the wound with allogenic mesenchymal stromal cells (MSCs) of Wharton\u2019s jelly (WJ-MSCs). Results: This double-stage therapy successfully modulated the inflammatory environment and stimulated granulation, facilitating final thoracoplasty and osteosynthesis. The patient achieved complete healing of the sternum, demonstrating benefits of WJ-MSCs in treating conservative treatment-resistant infections in the surgical wound. Conclusions: The advantages of using perinatal mesenchymal stem cells, with WJ-MSCs as a type of this class of MSCs, were demonstrated in treating chronically infected sternal surgical wounds. We also compared their regenerative properties to other stem cell types like bone marrow MSCs.<\/jats:p>","DOI":"10.3390\/diseases14010027","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T15:33:16Z","timestamp":1767886396000},"page":"27","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intradermal Application of Allogenic Wharton\u2019s Jelly Mesenchymal Stem Cells for Chronic Post-Thoracotomy Wound in an Elderly Patient After Coronary Artery Bypass Grafting: Clinical Case with Brief Literature Review"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2047-1497","authenticated-orcid":false,"given":"Anastassiya","family":"Ganina","sequence":"first","affiliation":[{"name":"JSC National Scientific Medical Center, 42 Abylay Khan Ave., Astana 010009, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abay","family":"Baigenzhin","sequence":"additional","affiliation":[{"name":"JSC National Scientific Medical Center, 42 Abylay Khan Ave., Astana 010009, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmira","family":"Chuvakova","sequence":"additional","affiliation":[{"name":"JSC National Scientific Medical Center, 42 Abylay Khan Ave., Astana 010009, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naizabek","family":"Yerzhigit","sequence":"additional","affiliation":[{"name":"JSC National Scientific Medical Center, 42 Abylay Khan Ave., Astana 010009, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuar","family":"Zhunussov","sequence":"additional","affiliation":[{"name":"JSC National Scientific Medical Center, 42 Abylay Khan Ave., Astana 010009, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aizhan","family":"Akhayeva","sequence":"additional","affiliation":[{"name":"JSC National Scientific Medical Center, 42 Abylay Khan Ave., Astana 010009, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Kozina","sequence":"additional","affiliation":[{"name":"JSC National Scientific Medical Center, 42 Abylay Khan Ave., Astana 010009, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9544-1885","authenticated-orcid":false,"given":"Oleg","family":"Lookin","sequence":"additional","affiliation":[{"name":"JSC National Scientific Medical Center, 42 Abylay Khan Ave., Astana 010009, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manarbek","family":"Askarov","sequence":"additional","affiliation":[{"name":"JSC National Scientific Medical Center, 42 Abylay Khan Ave., Astana 010009, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/iwj.13324","article-title":"Deep sternal wound infection following cardiac surgery: A comparison of the monolateral with the bilateral pectoralis major flaps","volume":"17","author":"Turriziani","year":"2020","journal-title":"Int. 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