{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T22:16:16Z","timestamp":1769120176242,"version":"3.49.0"},"reference-count":47,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Provincial Secretariat for Higher Education and Scientific Research of the Autonomous Province of Vojvodina","award":["0032710122024 09418 003 000 000 001 04 003"],"award-info":[{"award-number":["0032710122024 09418 003 000 000 001 04 003"]}]},{"DOI":"10.13039\/501100016047","name":"Science Fund of the Republic of Serbia","doi-asserted-by":"crossref","award":["7580"],"award-info":[{"award-number":["7580"]}],"id":[{"id":"10.13039\/501100016047","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>Objective: The aim of this study was to evaluate the impact of chronic kidney disease (CKD) on clinical presentation, laboratory parameters, ECG, and echocardiographic features of patients with chronic heart failure (CHF). Methods: This retrospective cross-sectional study included 2227 patients hospitalized in a tertiary care center due to CHF. Patients were divided into two groups based on the presence of CKD, defined as eGFR &lt; 60 mL\/min\/1.73 m2. Demographic, clinical, laboratory, and echocardiographic data were collected for all patients. Comparative analyses were performed to assess differences in cardiovascular risk factors, comorbidities, laboratory parameters, and echocardiographic findings between the two groups. Results: The proportion of men was significantly higher in the non-CKD group, whereas women predominated in the CKD group (p &lt; 0.001). Dyspnea, orthopnea, leg swelling, claudication, and expectoration were significantly more frequent in patients with CKD, while chest pain and palpitations were more common in the non-CKD group (all p &lt; 0.05). A significant difference in the distribution of NYHA functional classes was observed between the groups (p &lt; 0.001), with NYHA class IV being more prevalent in the CKD group and classes II and III more frequent in the non-CKD group. Levels of CRP and NT-proBNP were significantly higher in the CKD group (p &lt; 0.001). In-hospital mortality was 2.5-fold higher in patients with CKD (28.6% vs. 11.1%; p &lt; 0.001). Conclusions: Coexistence of CKD was associated with a more severe clinical presentation, advanced functional limitation, and a distinct laboratory and echocardiographic profile in CHF patients.<\/jats:p>","DOI":"10.3390\/diseases14010035","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T11:27:58Z","timestamp":1768908478000},"page":"35","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Chronic Kidney Disease on Clinical, Laboratory, and Echocardiographic Features in Patients with Chronic Heart Failure"],"prefix":"10.3390","volume":"14","author":[{"given":"Anastasija","family":"Ili\u0107","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivera","family":"Kova\u010devi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of 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Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragica","family":"Andri\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"},{"name":"Institute of Cardiovascular Diseases Vojvodina, 21204 Sremska Kamenica, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4317-5068","authenticated-orcid":false,"given":"Dragana","family":"Dabovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"},{"name":"Institute of Cardiovascular Diseases Vojvodina, 21204 Sremska Kamenica, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8774-1810","authenticated-orcid":false,"given":"Milana","family":"Jarakovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"},{"name":"Institute of Cardiovascular Diseases Vojvodina, 21204 Sremska Kamenica, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srdjan","family":"Maletin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"},{"name":"Institute of Cardiovascular Diseases Vojvodina, 21204 Sremska Kamenica, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teodora","family":"Panti\u0107","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Diseases Vojvodina, 21204 Sremska Kamenica, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Branislav","family":"Crnomarkovi\u0107","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Diseases Vojvodina, 21204 Sremska Kamenica, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihaela","family":"Preveden","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"},{"name":"Institute of Cardiovascular Diseases Vojvodina, 21204 Sremska Kamenica, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7383-6771","authenticated-orcid":false,"given":"Ranko","family":"Zdravkovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"},{"name":"Institute of Cardiovascular Diseases Vojvodina, 21204 Sremska Kamenica, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastazija","family":"Stoj\u0161i\u0107 Milosavljevi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"},{"name":"Institute of Cardiovascular Diseases Vojvodina, 21204 Sremska Kamenica, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5099-538X","authenticated-orcid":false,"given":"Aleksandra","family":"Ili\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"},{"name":"Institute of Cardiovascular Diseases Vojvodina, 21204 Sremska Kamenica, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2907-819X","authenticated-orcid":false,"given":"Lazar","family":"Velicki","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"},{"name":"Institute of Cardiovascular Diseases Vojvodina, 21204 Sremska Kamenica, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3572-2604","authenticated-orcid":false,"given":"Andrej","family":"Preveden","sequence":"additional","affiliation":[{"name":"Faculty of 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