{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:46:22Z","timestamp":1788993982526,"version":"build-2803163510"},"reference-count":43,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:00:00Z","timestamp":1769126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Diater Laboratories S.A."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>Background\/Objectives: The aim of this study was to evaluate the tolerability and effectiveness of subcutaneous immunotherapy (SCIT) in allergic adults and children treated with a polymerized-glutaraldehyde undiluted mixture of house dust mites (HDMs) under routine clinical practice. Methods: This was an observational, ambispective, controlled, real-world, multicenter study including patients \u2265 5 years with allergic rhinitis (AR), due to Dermatophagoides sensitization. Patients who started AIT with a D. pteronyssinus\/D. farinae extract and those who continued symptomatic treatment were included in the treatment (DP&amp;DF) and untreated (UT) groups, respectively. We evaluated adverse reactions (ARs) and changes in effectiveness variables through changes in symptoms, disease control, medication use, and patient- and investigator-reported outcomes. Results: We included 130 patients in the DP&amp;DF group, and 90 (69.2%) adults, 23 adolescents (17.7%), 17 (13.1%) children, and 94 patients in the UT group. Patients received treatment for a mean (SD) of 9.01 (3.1) months at the time of evaluation. Seven (5.4%) patients, all adults, reported eight ARs, five local and three systemic (mean rate of 0.62 ARs per 100 injections); all recovered, and epinephrine was not required. The proportion of patients reporting no rhinitis symptoms at follow-up significantly increased (+13.6%; p &lt; 0.001). Rhinitis frequency, intensity, and control significantly improved overall and in specific age groups. Similarly, the proportion of patients reporting no asthma symptoms at follow-up significantly increased (+29.0%; p &lt; 0.001). The use of all symptomatic medications significantly decreased, while the UT group showed no significant changes, except for worsened asthma classification and control in specific age groups. Both investigators and patients perceived a marked improvement in symptoms and medication use, with high satisfaction scores reported on the visual analogue scale. Conclusions: A subcutaneous allergen extract with a mixture of HDMs is safe and effective for allergic rhinitis and asthma in adults and children in the real-world setting.<\/jats:p>","DOI":"10.3390\/diseases14020037","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T17:52:38Z","timestamp":1769190758000},"page":"37","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Safety and Effectiveness of Subcutaneous Immunotherapy with a Glutaraldehyde-Polymerized Mite Allergen Extract in Adults and Children with Allergic Rhinitis with or Without Asthma Due to Dermatophagoides"],"prefix":"10.3390","volume":"14","author":[{"given":"Olalla","family":"Verdeguer Segarra","sequence":"first","affiliation":[{"name":"Allergy Unit, Hospital Francesc de Borja, 46702 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0721-4610","authenticated-orcid":false,"given":"Zulay","family":"Almeida S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Allergy Unit, Hospital Universitario de La Palma, 38713 Santa Cruz de Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Quarta","sequence":"additional","affiliation":[{"name":"Allergology Service, Hospital Universitari Sagrat Cor, 08029 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Funes Vera","sequence":"additional","affiliation":[{"name":"Allergology Unit, Hospital Universitario Rafael Mendez, 30817 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4798-154X","authenticated-orcid":false,"given":"\u00d3scar M.","family":"Gonz\u00e1lez Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Allergy Unit, Hospital Quir\u00f3n, 08029 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guacimara","family":"Hern\u00e1ndez Santana","sequence":"additional","affiliation":[{"name":"Service of Allergy, Hospital Universitario Nuestra Se\u00f1ora de Candelaria, 38010 Santa Cruz de Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Herrero Lifona","sequence":"additional","affiliation":[{"name":"Allergy Department, Hospital Quironsalud M\u00e1laga, 29004 M\u00e1laga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6708-3077","authenticated-orcid":false,"given":"Paula","family":"L\u00f3pez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Allergy Department, Infanta Leonor University Hospital, 28031 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3082-3898","authenticated-orcid":false,"given":"Montserrat","family":"Mart\u00ednez-Gomariz","sequence":"additional","affiliation":[{"name":"Research and Development Department, Diater Laboratories, 28919 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7748-6606","authenticated-orcid":false,"given":"Beatriz","family":"L\u00f3pez-Cauce","sequence":"additional","affiliation":[{"name":"Medical Affairs Department, Diater Laboratories, 28919 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A\u00edda","family":"G\u00f3mez-Cardenosa","sequence":"additional","affiliation":[{"name":"Medical Affairs Department, Diater Laboratories, 28919 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e12130","DOI":"10.1002\/clt2.12130","article-title":"Worldwide Prevalence of Rhinitis in Adults: A Review of Definitions and Temporal Evolution","volume":"12","author":"Bousquet","year":"2022","journal-title":"Clin. 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