{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T16:02:46Z","timestamp":1792252966485,"version":"4.4.0"},"reference-count":278,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diseases"],"abstract":"<jats:p>A compelling body of evidence links pesticide exposure to human diseases. The liver plays a central role in the detoxification of pesticides, suggesting intense pesticide\u2013liver cell interactions. A growing body of studies highlighted in this review supports the contribution of pesticides of various chemical classes to the development of non-alcoholic fatty liver disease (NAFLD), alcohol-associated liver disease (ALD), liver cirrhosis, viral hepatitis, hepatocellular carcinoma, etc., via disrupting lipid and carbohydrate metabolism and redox homeostasis, promoting endoplasmic reticulum stress and mitochondrial dysfunction, as well as stimulating apoptosis, fibrosis, and inflammation. In this review, we systematically illustrated an underappreciated mechanism of pesticide-induced overall and hepatic toxicity, i.e., the ability to induce non-apoptotic regulated cell death (RCD) pathways such as ferroptosis, necroptosis, and pyroptosis. Our analysis indicates that pesticides are implicated in driving liver diseases by inducing ferroptosis, necroptosis, and pyroptosis. Non-apoptotic RCDs mediate pesticide-induced liver steatosis and fibrosis. Furthermore, these cell death modalities fuel inflammation through the promotion of pro-inflammatory cytokine production and the generation of damage-associated molecular patterns. Understanding of deeper mechanisms of pesticide-induced effects on the non-apoptotic cell death machinery and subsequent immunogenic effects in liver pathology might help develop novel preventive strategies to reduce liver damage.<\/jats:p>","DOI":"10.3390\/diseases14030096","type":"journal-article","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T14:19:21Z","timestamp":1772720361000},"page":"96","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pesticides Drive Liver Diseases Through Non-Apoptotic Regulated Cell Death Pathways"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4156-565X","authenticated-orcid":false,"given":"Zamza","family":"Khairullina","sequence":"first","affiliation":[{"name":"Department of Microbiology, Virology and Immunology, West Kazakhstan Marat Ospanov Medical University, 68 Maresyev St., Aktobe 030000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saulesh","family":"Kurmangaliyeva","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Virology and Immunology, West Kazakhstan Marat Ospanov Medical University, 68 Maresyev St., Aktobe 030000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1899-2146","authenticated-orcid":false,"given":"Rustam","family":"Yussupov","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Virology and Immunology, Asfendiyarov Kazakh National Medical University, 94 Tole bi St., Almaty 050000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmira","family":"Kelimberdiyeva","sequence":"additional","affiliation":[{"name":"Department of General Medical Practice, Astana Medical University, 49\/A Beibitshilik St., Astana 010000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0307-3048","authenticated-orcid":false,"given":"Liliya","family":"Tryfonyuk","sequence":"additional","affiliation":[{"name":"Institute of Health, National University of Water and Environmental Engineering, 11 Soborna St., 33028 Rivne, Ukraine"},{"name":"Rivne Regional Clinical Hospital, 78g Kyivska St., 33007 Rivne, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasriddin","family":"Shapambayev","sequence":"additional","affiliation":[{"name":"Department of General Practitioner No. 1, Khoja Akhmet Yasawi International Kazakh-Turkish University, 7\/7 Baitursynov St., Shymkent 160012, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5794-3814","authenticated-orcid":false,"given":"Aizat","family":"Seidakhmetova","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine and Nursing, South Kazakhstan Medical Academy, 1\/1 Al-Farabi Sq., Shymkent 160019, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0781-2250","authenticated-orcid":false,"given":"Talgat","family":"Medetbekov","sequence":"additional","affiliation":[{"name":"Department of Surgical Diseases No. 2, Asfendiyarov Kazakh National Medical University, 94 Tole bi St., Almaty 050000, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1029-1636","authenticated-orcid":false,"given":"Anton","family":"Tkachenko","sequence":"additional","affiliation":[{"name":"BIOCEV, First Faculty of Medicine, Charles University, Pr\u016fmyslov\u00e1 595, 25250 Vestec, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e29128","DOI":"10.1016\/j.heliyon.2024.e29128","article-title":"Pesticides impacts on human health and the environment with their mechanisms of action and possible countermeasures","volume":"10","author":"Ahmad","year":"2024","journal-title":"Heliyon"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"170113","DOI":"10.1016\/j.scitotenv.2024.170113","article-title":"Pesticides: An alarming detrimental to health and environment","volume":"915","author":"Kaur","year":"2024","journal-title":"Sci. Total Environ."},{"key":"ref_3","first-page":"e67945","article-title":"A Scientific Review of Pesticides: Classification, Toxicity, Health Effects, Sustainability, and Environmental Impact","volume":"16","author":"Garud","year":"2024","journal-title":"Cureus"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Pathak, V.M., Verma, V.K., Rawat, B.S., Kaur, B., Babu, N., Sharma, A., Dewali, S., Yadav, M., Kumari, R., and Singh, S. (2022). Current status of pesticide effects on environment, human health and it\u2019s eco-friendly management as bioremediation: A comprehensive review. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.962619"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/s41597-025-05031-7","article-title":"Pesticides application rate maps in the European Union at a 250\u2009m spatial resolution","volume":"12","author":"Porta","year":"2025","journal-title":"Sci. Data"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"daaf001","DOI":"10.1093\/heapro\/daaf001","article-title":"Mapping commercial practices of the pesticide industry to shape science and policymaking: A scoping review","volume":"40","author":"Petticrew","year":"2025","journal-title":"Health Promot. Int."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Perobelli, J.E. (2025). Pesticides and public health: Discussing risks in Brazilian agro-industrial growth. Front. Toxicol., 7.","DOI":"10.3389\/ftox.2025.1442801"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"31905","DOI":"10.1038\/s41598-024-83298-3","article-title":"The social costs of pesticides: A meta-analysis of the experimental and stated preference literature","volume":"14","author":"Rufo","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"101840","DOI":"10.1016\/j.toxrep.2024.101840","article-title":"A systematic review of pesticide exposure, associated risks, and long-term human health impacts","volume":"13","author":"Shekhar","year":"2024","journal-title":"Toxicol. Rep."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Moreira, A., and Vieira da Silva, M. (2024). Analysis of Health Effects Reported by Agricultural Workers and the Adverse Human Effects Indicated on Pesticide Labels: A Systematic Review. Agriculture, 14.","DOI":"10.3390\/agriculture14101669"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Botnaru, A.A., Lupu, A., Morariu, P.C., Jit\u0103reanu, A., Nedelcu, A.H., Morariu, B.A., Anton, E., Di Gioia, M.L., Lupu, V.V., and Dragostin, O.M. (2025). Neurotoxic Effects of Pesticides: Implications for Neurodegenerative and Neurobehavioral Disorders. J. Xenobiot., 15.","DOI":"10.3390\/jox15030083"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez, A., Castrej\u00f3n-God\u00ednez, M.L., and Monterrosas-Brisson, N. (2025). Pesticides: Environmental Stressors Implicated in the Development of Central Nervous System Disorders and Neurodegeneration. Stresses, 5.","DOI":"10.3390\/stresses5020031"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3944","DOI":"10.1080\/17441692.2020.1808693","article-title":"Pesticide exposure and risk of cardiovascular disease: A systematic review","volume":"17","author":"Zago","year":"2022","journal-title":"Glob. Public Health"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1093\/aje\/kwae118","article-title":"Residential proximity to agricultural pesticide use and cardiovascular disease risk factors among adult Latina women in California\u2019s Salinas Valley","volume":"193","author":"Calderon","year":"2024","journal-title":"Am. J. Epidemiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"15","DOI":"10.36922\/jctr.22.00187","article-title":"Association between pesticide exposure and ischemic heart disease among adults who took part in the Rafsanjan cohort study","volume":"11","author":"Pourmasumi","year":"2025","journal-title":"J. Clin. Transl. Res."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"He, J., Wang, H., and Li, X. (2025). Pesticide exposure and cardiovascular health in non-CVD mortality population: Novel evidence from NHANES 2007\u20132018 using Life\u2019s Essential 8. Front. Nutr., 12.","DOI":"10.3389\/fnut.2025.1578796"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"6442","DOI":"10.3390\/ijerph10126442","article-title":"Occupational Pesticide Exposures and Respiratory Health","volume":"10","author":"Ye","year":"2013","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1183\/16000617.00006014","article-title":"Occupational exposure to pesticides and respiratory health","volume":"24","author":"Mamane","year":"2015","journal-title":"Eur. Respir. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1097\/MCP.0000000000000777","article-title":"Pulmonary toxicity associated with occupational and environmental exposure to pesticides and herbicides","volume":"27","author":"Bast","year":"2021","journal-title":"Curr. Opin. Pulm. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"104076","DOI":"10.1016\/j.etap.2023.104076","article-title":"Environmental pesticide exposure and the risk of irritable bowel syndrome: A case-control study","volume":"98","author":"Roman","year":"2023","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1038\/s41396-023-01450-9","article-title":"Pesticide exposure and the microbiota-gut-brain axis","volume":"17","author":"Matsuzaki","year":"2023","journal-title":"ISME J."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Gama, J., Neves, B., and Pereira, A. (2022). Chronic Effects of Dietary Pesticides on the Gut Microbiome and Neurodevelopment. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.931440"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"13","DOI":"10.5271\/sjweh.1060","article-title":"Influence of pesticides on male fertility","volume":"33","author":"Bretveld","year":"2007","journal-title":"Scand. J. Work. Environ. Health"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e240379","DOI":"10.1530\/JOE-24-0379","article-title":"Impact of pesticides on reproductive health: Insights from animal and in vitro models in both sexes","volume":"266","author":"Pomacena","year":"2025","journal-title":"J. Endocrinol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Uwamahoro, C., Jo, J.H., Jang, S.I., Jung, E.J., Lee, W.J., Bae, J.W., and Kwon, W.S. (2024). Assessing the Risks of Pesticide Exposure: Implications for Endocrine Disruption and Male Fertility. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25136945"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1002\/ijc.34300","article-title":"Exposures to pesticides and risk of cancer: Evaluation of recent epidemiological evidence in humans and paths forward","volume":"152","author":"Cavalier","year":"2023","journal-title":"Int. J. Cancer"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1515\/reveh-2022-0253","article-title":"Residues of carcinogenic pesticides in food: A systematic review","volume":"39","author":"Sadighara","year":"2024","journal-title":"Rev. Environ. Health"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Sass, J.B., Donley, N., and Freese, W. (2024). Neonicotinoid pesticides: Evidence of developmental neurotoxicity from regulatory rodent studies. Front. Toxicol., 6.","DOI":"10.3389\/ftox.2024.1438890"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Souto, A.L., Sylvestre, M., T\u00f6lke, E.D., Tavares, J.F., Barbosa-Filho, J.M., and Cebri\u00e1n-Torrej\u00f3n, G. (2021). Plant-Derived Pesticides as an Alternative to Pest Management and Sustainable Agricultural Production: Prospects, Applications and Challenges. Molecules, 26.","DOI":"10.3390\/molecules26164835"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Devrnja, N., Milutinovi\u0107, M., and Savi\u0107, J. (2022). When Scent Becomes a Weapon\u2014Plant Essential Oils as Potent Bioinsecticides. Sustainability, 14.","DOI":"10.3390\/su14116847"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Ara\u00fajo, M.F., Castanheira, E.M.S., and Sousa, S.F. (2023). The Buzz on Insecticides: A Review of Uses, Molecular Structures, Targets, Adverse Effects, and Alternatives. Molecules, 28.","DOI":"10.3390\/molecules28083641"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bbrc.2023.05.107","article-title":"Diamide insecticides targeting insect ryanodine receptors: Mechanism and application prospect","volume":"670","author":"Du","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"El-Saber Batiha, G., Alqahtani, A., Ilesanmi, O.B., Saati, A.A., El-Mleeh, A., Hetta, H.F., and Magdy Beshbishy, A. (2020). Avermectin Derivatives, Pharmacokinetics, Therapeutic and Toxic Dosages, Mechanism of Action, and Their Biological Effects. Pharmaceuticals, 13.","DOI":"10.3390\/ph13080196"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"182","DOI":"10.4103\/0972-5229.117074","article-title":"Paraquat\u2014A deadly poison: Report of a case and review","volume":"17","author":"Saravu","year":"2013","journal-title":"Indian J. Crit. Care Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1021\/tx8004949","article-title":"Pest toxicology: The primary mechanisms of pesticide action","volume":"22","author":"Casida","year":"2009","journal-title":"Chem. Res. Toxicol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"169079","DOI":"10.1016\/j.scitotenv.2023.169079","article-title":"Assessment of the impacts of GABA and AChE targeting pesticides on freshwater invertebrate family richness in English Rivers","volume":"912","author":"Harrison","year":"2024","journal-title":"Sci. Total Environ."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Al Naggar, Y., Fahmy, N.M., Alkhaibari, A.M., Al-Akeel, R.K., Alharbi, H.M., Mohamed, A., Eleftherianos, I., El-Seedi, H.R., Giesy, J.P., and Alharbi, H.A. (2025). Mechanisms and Genetic Drivers of Resistance of Insect Pests to Insecticides and Approaches to Its Control. Toxics, 13.","DOI":"10.3390\/toxics13080681"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1080\/15563650.2019.1582776","article-title":"Medical outcomes of bromethalin rodenticide exposures reported to US poison centers after federal restriction of anticoagulants","volume":"57","author":"Feldman","year":"2019","journal-title":"Clin. Toxicol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/ps.2780430112","article-title":"Warfarin-based rodenticides: Mode of action and mechanism of resistance","volume":"43","author":"Thijssen","year":"1995","journal-title":"Pestic. Sci."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1021\/acs.est.8b04392","article-title":"Fungicides: An Overlooked Pesticide Class?","volume":"53","author":"Zubrod","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"He, B., Hu, Y., Wang, W., Yan, W., and Ye, Y. (2022). The Progress towards Novel Herbicide Modes of Action and Targeted Herbicide Development. Agronomy, 12.","DOI":"10.3390\/agronomy12112792"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"5563759","DOI":"10.1155\/2022\/5563759","article-title":"A Common Feature of Pesticides: Oxidative Stress-The Role of Oxidative Stress in Pesticide-Induced Toxicity","volume":"2022","author":"Sule","year":"2022","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"173545","DOI":"10.1016\/j.scitotenv.2024.173545","article-title":"A Th2-type immune response and low-grade systemic inflammatory reaction as potential immunotoxic effects in intensive agriculture farmers exposed to pesticides","volume":"938","author":"Requena","year":"2024","journal-title":"Sci. Total Environ."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Lopes-Ferreira, M., Farinha, L.R.L., Costa, Y.S.O., Pinto, F.J., Disner, G.R., da Rosa, J., and Lima, C. (2023). Pesticide-Induced Inflammation at a Glance. Toxics, 11.","DOI":"10.3390\/toxics11110896"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/s41419-020-03221-2","article-title":"Detection of immunogenic cell death and its relevance for cancer therapy","volume":"11","author":"Fucikova","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e000337","DOI":"10.1136\/jitc-2019-000337","article-title":"Consensus guidelines for the definition, detection and interpretation of immunogenic cell death","volume":"8","author":"Galluzzi","year":"2020","journal-title":"J. Immunother. Cancer"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"3874","DOI":"10.1016\/j.molcel.2025.09.007","article-title":"DAMPs in the immunogenicity of cell death","volume":"85","author":"Chen","year":"2025","journal-title":"Mol. Cell"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"22206","DOI":"10.1002\/cam4.6803","article-title":"PANoptosis in cancer, the triangle of cell death","volume":"12","author":"Cai","year":"2023","journal-title":"Cancer Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/s41573-024-00920-9","article-title":"Targeting immunogenic cell stress and death for cancer therapy","volume":"23","author":"Galluzzi","year":"2024","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1038\/s41423-020-00630-3","article-title":"Necroptosis, pyroptosis and apoptosis: An intricate game of cell death","volume":"18","author":"Bertheloot","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","article-title":"Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018","volume":"25","author":"Galluzzi","year":"2018","journal-title":"Cell Death Differ"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Dongiovanni, P., and Meroni, M. (2025). New Challenges in the Study of Liver Diseases: From Molecular Pathogenesis to Therapeutic Approaches (3rd Edition). Biomedicines, 13.","DOI":"10.3390\/biomedicines13122879"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41392-024-02072-z","article-title":"Liver diseases: Epidemiology, causes, trends and predictions","volume":"10","author":"Gan","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.jhep.2023.03.017","article-title":"Global burden of liver disease: 2023 update","volume":"79","author":"Devarbhavi","year":"2023","journal-title":"J. Hepatol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"197","DOI":"10.7570\/jomes23052","article-title":"Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A State-of-the-Art Review","volume":"32","author":"Chan","year":"2023","journal-title":"J. Obes. Metab. Syndr."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Portincasa, P., Khalil, M., Mahdi, L., Perniola, V., Idone, V., Graziani, A., Baffy, G., and Di Ciaula, A. (2024). Metabolic Dysfunction-Associated Steatotic Liver Disease: From Pathogenesis to Current Therapeutic Options. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25115640"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"goae069","DOI":"10.1093\/gastro\/goae069","article-title":"Current epidemiology of chronic liver disease","volume":"12","author":"Manikat","year":"2024","journal-title":"Gastroenterol. Rep."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Kurmangaliyeva, S., Baktikulova, K., Tkachenko, A., Seitkhanova, B., Tryfonyuk, L., Rakhimzhanova, F., Yussupov, R., and Kurmangaliyev, K. (2025). Eryptosis in Liver Diseases: Contribution to Anemia and Hypercoagulation. Med. Sci., 13.","DOI":"10.3390\/medsci13030125"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e070201","DOI":"10.1136\/bmj-2022-070201","article-title":"Diagnosis and management of autoimmune hepatitis","volume":"380","author":"Muratori","year":"2023","journal-title":"BMJ"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"124381","DOI":"10.1016\/j.ijpharm.2024.124381","article-title":"Targeting chronic liver diseases: Molecular markers, drug delivery strategies and future perspectives","volume":"660","author":"Unagolla","year":"2024","journal-title":"Int. J. Pharm."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s44276-024-00050-0","article-title":"Progression of chronic liver disease to hepatocellular carcinoma: Implications for surveillance and management","volume":"2","author":"Johnson","year":"2024","journal-title":"BJC Rep."},{"key":"ref_62","unstructured":"Sharma, A., and Nagalli, S. (2025). Chronic Liver Disease. StatPearls, StatPearls Publishing LLC."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"\u00d6zkan, A., Stolley, D., Cressman, E.N.K., McMillin, M., DeMorrow, S., Yankeelov, T.E., and Rylander, M.N. (2020). The Influence of Chronic Liver Diseases on Hepatic Vasculature: A Liver-on-a-chip Review. Micromachines, 11.","DOI":"10.3390\/mi11050487"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"30269","DOI":"10.3390\/ijms161226225","article-title":"Oxidative Stress and Inflammation in Hepatic Diseases: Therapeutic Possibilities of N-Acetylcysteine","volume":"16","author":"Moura","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.ajpath.2023.06.002","article-title":"Oxidative Stress\u2013Induced Liver Damage and Remodeling of the Liver Vasculature","volume":"193","author":"Banerjee","year":"2023","journal-title":"Am. J. Pathol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1053\/j.gastro.2008.03.002","article-title":"Cellular and molecular mechanisms of liver injury","volume":"134","author":"Malhi","year":"2008","journal-title":"Gastroenterology"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"11590","DOI":"10.1038\/s41598-022-15741-2","article-title":"Association between organochlorine pesticides and nonalcoholic fatty liver disease in the National Health and Nutrition Examination Survey 2003\u20132004","volume":"12","author":"Sang","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"10132","DOI":"10.1021\/acs.jafc.8b03177","article-title":"Insecticide Exposure and Development of Nonalcoholic Fatty Liver Disease","volume":"66","author":"Yang","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.envres.2015.09.027","article-title":"Pesticide exposure and hepatocellular carcinoma risk: A case-control study using a geographic information system (GIS) to link SEER-Medicare and California pesticide data","volume":"143","author":"VoPham","year":"2015","journal-title":"Environ. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ijheh.2005.04.003","article-title":"Associations of pesticides, HCV, HBV, and hepatocellular carcinoma in Egypt","volume":"208","author":"Ezzat","year":"2005","journal-title":"Int. J. Hyg. Environ. Health"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12995-025-00470-9","article-title":"Associations between pesticide exposure and hepatobiliary disease among agricultural workers in the Northeastern region of Thailand: A cross-sectional study","volume":"20","author":"Kopolrat","year":"2025","journal-title":"J. Occup. Med. Toxicol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"21041","DOI":"10.1038\/s41598-025-04295-8","article-title":"Neurological and organ health risks associated with pesticide mixture exposure in banana farm workers in Moungo Division, Cameroon","volume":"15","author":"Nanhah","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Mehta, P., Parajuli, R.P., Chronister, B.N.C., Yang, K., Barr, D.B., Tu, X.M., Lopez-Paredes, D., and Suarez-Lopez, J.R. (2025). Pesticide and Liver Biomarkers Among Ecuadorian Adolescents and Adults Living in Agricultural Settings. Toxics, 13.","DOI":"10.3390\/toxics13080685"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1111\/liv.15461","article-title":"Organophosphate pesticide exposure and biomarkers of liver injury\/liver function","volume":"42","author":"Li","year":"2022","journal-title":"Liver Int."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"7826396","DOI":"10.1155\/2022\/7826396","article-title":"Selected Liver Markers in Predicting the Severity of Organophosphate and Carbamate Poisoning","volume":"2022","author":"Senarathne","year":"2022","journal-title":"J. Environ. Public Health"},{"key":"ref_76","first-page":"1","article-title":"Enzymatic detoxification of organophosphorus pesticides and related toxicants","volume":"43","year":"2018","journal-title":"J. Pestic. Sci."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"118854","DOI":"10.1016\/j.ecoenv.2025.118854","article-title":"Xenobiotic-induced liver injury: Molecular mechanisms and disease progression","volume":"303","author":"Wang","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1021\/tx700133c","article-title":"Glutathione S-Transferase Conjugation of Organophosphorus Pesticides Yields S-Phospho-, S-Aryl-, and S-Alkylglutathione Derivatives","volume":"20","author":"Fujioka","year":"2007","journal-title":"Chem. Res. Toxicol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"139033","DOI":"10.1016\/j.scitotenv.2020.139033","article-title":"Pesticides-induced energy metabolic disorders","volume":"729","author":"He","year":"2020","journal-title":"Sci. Total Environ."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s13273-025-00521-6","article-title":"Overview of the hazardous impacts of metabolism-disrupting chemicals on the progression of fatty liver diseases","volume":"21","author":"An","year":"2025","journal-title":"Mol. Cell. Toxicol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"119915","DOI":"10.1016\/j.envpol.2022.119915","article-title":"Analysis of environmental chemical mixtures and nonalcoholic fatty liver disease: NHANES 1999\u20132014","volume":"311","author":"Li","year":"2022","journal-title":"Environ. Pollut"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"4020249","DOI":"10.1155\/2020\/4020249","article-title":"An Overview of Lipid Metabolism and Nonalcoholic Fatty Liver Disease","volume":"2020","author":"Pei","year":"2020","journal-title":"Biomed. Res. Int."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1021\/jf60183a040","article-title":"Mechanism of dieldrin-induced fat accumulation in rat liver","volume":"20","author":"Bhatia","year":"1972","journal-title":"J. Agric. Food Chem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"46339","DOI":"10.1038\/srep46339","article-title":"Organochloride pesticides impaired mitochondrial function in hepatocytes and aggravated disorders of fatty acid metabolism","volume":"7","author":"Liu","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"9293","DOI":"10.1021\/acs.jafc.6b04322","article-title":"Imidacloprid Promotes High Fat Diet-Induced Adiposity and Insulin Resistance in Male C57BL\/6J Mice","volume":"64","author":"Sun","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.fct.2019.02.005","article-title":"Permethrin and ivermectin modulate lipid metabolism in steatosis-induced HepG2 hepatocyte","volume":"125","author":"Yang","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"107021","DOI":"10.1016\/j.aquatox.2024.107021","article-title":"Permethrin exposure impacts zebrafish lipid metabolism via the KRAS-PPAR-GLUT signaling pathway, which is mediated by oxidative stress","volume":"273","author":"Khan","year":"2024","journal-title":"Aquat. Toxicol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1093\/toxsci\/kfy205","article-title":"Insights into a Possible Mechanism Underlying the Connection of Carbendazim-Induced Lipid Metabolism Disorder and Gut Microbiota Dysbiosis in Mice","volume":"166","author":"Jin","year":"2018","journal-title":"Toxicol. Sci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.envpol.2017.10.129","article-title":"Exposure to the fungicide propamocarb causes gut microbiota dysbiosis and metabolic disorder in mice","volume":"237","author":"Wu","year":"2018","journal-title":"Environ. Pollut."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.lfs.2005.06.010","article-title":"Effect of dichlorvos on hepatic and pancreatic glucokinase activity and gene expression, and on insulin mRNA levels","volume":"78","year":"2006","journal-title":"Life Sci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.cca.2004.03.009","article-title":"Hyperglycemia associated with increased hepatic glycogen phosphorylase and phosphoenolpyruvate carboxykinase in rats following subchronic exposure to malathion","volume":"137","author":"Abdollahi","year":"2004","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/imcb.12297","article-title":"Hyperglycemia aggravates acute liver injury by promoting liver-resident macrophage NLRP3 inflammasome activation via the inhibition of AMPK\/mTOR-mediated autophagy induction","volume":"98","author":"Wang","year":"2020","journal-title":"Immunol. Cell Biol."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.cbi.2011.07.003","article-title":"Augmentation of hepatic and renal oxidative stress and disrupted glucose homeostasis by monocrotophos in streptozotocin-induced diabetic rats","volume":"193","author":"Begum","year":"2011","journal-title":"Chem. Biol. Interact."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Chen, T., Tan, J., Wan, Z., Zou, Y., Kessete Afewerky, H., Zhang, Z., and Zhang, T. (2017). Effects of Commonly Used Pesticides in China on the Mitochondria and Ubiquitin-Proteasome System in Parkinson\u2019s Disease. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18122507"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"112690","DOI":"10.1016\/j.ecoenv.2021.112690","article-title":"Neonicotinoid insecticides triggers mitochondrial bioenergetic dysfunction via manipulating ROS-calcium influx pathway in the liver","volume":"224","author":"Li","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.tox.2010.01.017","article-title":"Mitochondrial energy metabolism impairment and liver dysfunction following chronic exposure to dichlorvos","volume":"270","author":"Binukumar","year":"2010","journal-title":"Toxicology"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"06008","DOI":"10.1051\/bioconf\/202413006008","article-title":"Oxidative phosphorylation of rat liver mitochondria with intoxication of haloxyfop-r-methyl and indoxacarb pesticides","volume":"130","author":"Mirkhamidova","year":"2024","journal-title":"BIO Web Conf."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Alimova, A.A., Sitnikov, V.V., Pogorelov, D.I., Boyko, O.N., Vitkalova, I.Y., Gureev, A.P., and Popov, V.N. (2022). High Doses of Pesticides Induce mtDNA Damage in Intact Mitochondria of Potato In Vitro and Do Not Impact on mtDNA Integrity of Mitochondria of Shoots and Tubers under In Vivo Exposure. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23062970"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.etap.2017.11.005","article-title":"Chronic exposure to a glyphosate-containing pesticide leads to mitochondrial dysfunction and increased reactive oxygen species production in Caenorhabditis elegans","volume":"57","author":"Bailey","year":"2018","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"135560","DOI":"10.1016\/j.jhazmat.2024.135560","article-title":"Cadmium stress alleviates lipid accumulation caused by chiral penthiopyrad through regulating endoplasmic reticulum stress and mitochondrial dysfunction in zebrafish liver","volume":"478","author":"Wang","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"El Gazzar, W.B., Bayoumi, H., Youssef, H.S., Ibrahim, T.A., Abdelfatah, R.M., Gamil, N.M., Iskandar, M.K., Abdel-Kareim, A.M., Abdelrahman, S.M., and Gebba, M.A. (2024). Role of IRE1\u03b1\/XBP1\/CHOP\/NLRP3 Signalling Pathway in Neonicotinoid Imidacloprid-Induced Pancreatic Dysfunction in Rats and Antagonism of Lycopene: In Vivo and Molecular Docking Simulation Approaches. Toxics, 12.","DOI":"10.3390\/toxics12070445"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41392-024-01839-8","article-title":"Mitochondrial dysfunction: Mechanisms and advances in therapy","volume":"9","author":"Zong","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"171711","DOI":"10.1016\/j.scitotenv.2024.171711","article-title":"Exposure to the environmental pollutant chlorpyrifos induces hepatic toxicity through activation of the JAK\/STAT and MAPK pathways","volume":"928","author":"Fu","year":"2024","journal-title":"Sci. Total Environ."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"675","DOI":"10.18632\/aging.204298","article-title":"Ros-mediated mitochondrial oxidative stress is involved in the ameliorating effect of ginsenoside GSLS on chlorpyrifos-induced hepatotoxicity in mice","volume":"15","author":"Pei","year":"2022","journal-title":"Aging"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Qumsani, A.T. (2025). Exploring the Effects of Imidacloprid on Liver Health and the Microbiome in Rats: A Comprehensive Study. Microorganisms, 13.","DOI":"10.3390\/microorganisms13010015"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3892\/mmr.2025.13661","article-title":"MitoQ alleviates malathion-induced hepatorenal toxicity via oxidative stress and inflammation modulation","volume":"32","author":"Althobaiti","year":"2025","journal-title":"Mol. Med. Rep."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"285","DOI":"10.2131\/jts.36.285","article-title":"Hepatoprotective effects of vitamin E\/selenium against malathion-induced injuries on the antioxidant status and apoptosis-related gene expression in rats","volume":"36","author":"Yusuf","year":"2011","journal-title":"J. Toxicol. Sci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1007\/s10495-023-01915-4","article-title":"Apoptosis and eryptosis: Similarities and differences","volume":"29","author":"Tkachenko","year":"2024","journal-title":"Apoptosis"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1080\/09540105.2017.1373271","article-title":"Potential threat of Chlorpyrifos to human liver cells via the caspase-dependent mitochondrial pathways","volume":"29","author":"Zhang","year":"2018","journal-title":"Food Agric. Immunol."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Kwon, H.-C., Sohn, H., Kim, D.-H., Jeong, C.-H., Kim, D.-W., and Han, S.-G. (2021). Effects of Flutriafol Fungicide on the Lipid Accumulation in Human Liver Cells and Rat Liver. Foods, 10.","DOI":"10.3390\/foods10061346"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.toxrep.2018.11.008","article-title":"An imazamox-based herbicide causes apoptotic changes in rat liver and pancreas","volume":"6","author":"Sevim","year":"2019","journal-title":"Toxicol. Rep."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.tox.2011.07.004","article-title":"Hexachlorobenzene induces deregulation of cellular growth in rat liver","volume":"289","author":"Giribaldi","year":"2011","journal-title":"Toxicology"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/toxres\/tfaa108","article-title":"Effects of chlorpyrifos exposure on liver inflammation and intestinal flora structure in mice","volume":"10","author":"Zhang","year":"2021","journal-title":"Toxicol. Res."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"5841","DOI":"10.1007\/s11356-016-8323-4","article-title":"Pyrethroid insecticide lambda-cyhalothrin and its metabolites induce liver injury through the activation of oxidative stress and proinflammatory gene expression in rats following acute and subchronic exposure","volume":"24","author":"Aouey","year":"2017","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.pestbp.2012.06.011","article-title":"Chronic exposure to imidacloprid induces inflammation and oxidative stress in the liver & central nervous system of rats","volume":"104","author":"Duzguner","year":"2012","journal-title":"Pestic. Biochem. Physiol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"13147","DOI":"10.1038\/s41598-018-31599-9","article-title":"Gulf war illness-related chemicals increase CD11b\/c+ monocyte infiltration into the liver and aggravate hepatic cholestasis in a rodent model","volume":"8","author":"Petrescu","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"117776","DOI":"10.1016\/j.ecoenv.2025.117776","article-title":"Association between mixed exposure of non-persistent pesticides and liver fibrosis in the general US population: NHANES 2013\u20132016","volume":"290","author":"Shu","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"135177","DOI":"10.1016\/j.jhazmat.2024.135177","article-title":"Chlordecone-induced hepatotoxicity and fibrosis are mediated by the proteasomal degradation of septins","volume":"476","author":"Alilat","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.cgh.2019.03.045","article-title":"Glyphosate Excretion is Associated With Steatohepatitis and Advanced Liver Fibrosis in Patients with Fatty Liver Disease","volume":"18","author":"Mills","year":"2020","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"113870","DOI":"10.1016\/j.envpol.2019.113870","article-title":"Deltamethrin induces liver fibrosis in quails via activation of the TGF-\u03b21\/Smad signaling pathway","volume":"259","author":"Han","year":"2020","journal-title":"Environ. Pollut."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cbi.2018.07.008","article-title":"New insights into TGF-\u03b2\/Smad signaling in tissue fibrosis","volume":"292","author":"Hu","year":"2018","journal-title":"Chem. Biol. Interact."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"135915","DOI":"10.1016\/j.scitotenv.2019.135915","article-title":"Imidacloprid-induced liver fibrosis in quails via activation of the TGF-\u03b21\/Smad pathway","volume":"705","author":"Lv","year":"2020","journal-title":"Sci. Total Environ."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"112155","DOI":"10.1016\/j.fct.2021.112155","article-title":"Investigation of steatosis profiles induced by pesticides using liver organ-on-chip model and omics analysis","volume":"152","author":"Jellali","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Bonvallot, N., Canlet, C., Blas, Y.E.F., Gautier, R., Tremblay-Franco, M., Chevolleau, S., Cordier, S., and Cravedi, J.P. (2018). Metabolome disruption of pregnant rats and their offspring resulting from repeated exposure to a pesticide mixture representative of environmental contamination in Brittany. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0198448"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41420-025-02328-9","article-title":"Insights on the crosstalk among different cell death mechanisms","volume":"11","author":"Eskander","year":"2025","journal-title":"Cell Death Discov."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41422-019-0164-5","article-title":"The molecular machinery of regulated cell death","volume":"29","author":"Tang","year":"2019","journal-title":"Cell Res."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"e106700","DOI":"10.15252\/embj.2020106700","article-title":"Cell death pathways: Intricate connections and disease implications","volume":"40","author":"Kist","year":"2021","journal-title":"EMBO J."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Loftus, L.V., Amend, S.R., and Pienta, K.J. (2022). Interplay between Cell Death and Cell Proliferation Reveals New Strategies for Cancer Therapy. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23094723"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.immuni.2020.07.004","article-title":"Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection","volume":"53","author":"Doerflinger","year":"2020","journal-title":"Immunity"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"9912436","DOI":"10.1155\/2021\/9912436","article-title":"Reactive Oxygen Species (ROS) Regulates Different Types of Cell Death by Acting as a Rheostat","volume":"2021","author":"Gibson","year":"2021","journal-title":"Oxid. Med. Cell Longev."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Shojaie, L., Iorga, A., and Dara, L. (2020). Cell Death in Liver Diseases: A Review. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21249682"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1055\/a-2576-4332","article-title":"The Ways to Die: Cell Death in Liver Pathophysiology","volume":"45","author":"Cao","year":"2025","journal-title":"Semin. Liver Dis."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0168-8278(00)00089-1","article-title":"Hepatocyte apoptosis is a pathologic feature of human alcoholic hepatitis","volume":"34","author":"Natori","year":"2001","journal-title":"J. Hepatol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/s41420-023-01608-6","article-title":"Ferroptosis contributes to ethanol-induced hepatic cell death via labile iron accumulation and GPx4 inactivation","volume":"9","author":"Luo","year":"2023","journal-title":"Cell Death Discov."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Shi, J.-F., Liu, Y.e., Wang, Y., Gao, R., Wang, Y., and Liu, J. (2023). Targeting ferroptosis, a novel programmed cell death, for the potential of alcohol-related liver disease therapy. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1194343"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"e13193","DOI":"10.1111\/cpr.13193","article-title":"Roles of necroptosis in alcoholic liver disease and hepatic pathogenesis","volume":"55","author":"Zhou","year":"2022","journal-title":"Cell Prolif."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"114124","DOI":"10.1016\/j.fct.2023.114124","article-title":"Alcohol induces hepatocytes necroptosis through the LC3\/RIPK1\/RIPK3 pathway","volume":"182","author":"Chen","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"10489","DOI":"10.3168\/jds.2024-26233","article-title":"Yogurt alleviates alcohol-induced hepatocyte pyroptosis and inflammation via autophagy\/P62\/Nrf2\/ROS\/NLRP3 pathway","volume":"108","author":"Guan","year":"2025","journal-title":"J. Dairy. Sci."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"103879","DOI":"10.1016\/j.redox.2025.103879","article-title":"Perspective on alcohol-induced organ damage via autophagy-dependent cellular changes","volume":"87","author":"Bakheet","year":"2025","journal-title":"Redox Biol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1586\/egh.11.6","article-title":"Apoptosis in nonalcoholic fatty liver disease: Diagnostic and therapeutic implications","volume":"5","author":"Alkhouri","year":"2011","journal-title":"Expert. Rev. Gastroenterol. Hepatol."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Cheng, Z., Chu, H., Zhu, Q., and Yang, L. (2023). Ferroptosis in non-alcoholic liver disease: Molecular mechanisms and therapeutic implications. Front. Nutr., 10.","DOI":"10.3389\/fnut.2023.1090338"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"113374","DOI":"10.1016\/j.biopha.2022.113374","article-title":"An overview of ferroptosis in non-alcoholic fatty liver disease","volume":"153","author":"Wang","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1042\/CS20140732","article-title":"Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis","volume":"129","author":"Afonso","year":"2015","journal-title":"Clin. Sci."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.3748\/wjg.v30.i14.1968","article-title":"Necroptosis contributes to non-alcoholic fatty liver disease pathoetiology with promising diagnostic and therapeutic functions","volume":"30","author":"Sun","year":"2024","journal-title":"World J. Gastroenterol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"7325","DOI":"10.3748\/wjg.v20.i23.7325","article-title":"Role of autophagy in the pathophysiology of nonalcoholic fatty liver disease: A controversial issue","volume":"20","author":"Kwanten","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Shen, Q., Yang, M., Wang, S., Chen, X., Chen, S., Zhang, R., Xiong, Z., and Leng, Y. (2024). The pivotal role of dysregulated autophagy in the progression of non-alcoholic fatty liver disease. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1374644"},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Li, S.-J., Liu, A.-B., Yu, Y.-Y., and Ma, J.-H. (2024). The role and mechanism of pyroptosis and potential therapeutic targets in non-alcoholic fatty liver disease (NAFLD). Front. Cell Dev. Biol., 12.","DOI":"10.3389\/fcell.2024.1407738"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.jhep.2018.01.017","article-title":"Pyroptosis: An inflammatory link between NAFLD and NASH with potential therapeutic implications","volume":"68","author":"Beier","year":"2018","journal-title":"J. Hepatol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/j.dld.2025.04.011","article-title":"Emerging roles of cuproptosis in liver diseases","volume":"57","author":"Yang","year":"2025","journal-title":"Dig. Liver Dis."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"e70000","DOI":"10.1111\/liv.70000","article-title":"Unravelling the Role of PANoptosis in Liver Diseases: Mechanisms and Therapeutic Implications","volume":"45","author":"Xiong","year":"2025","journal-title":"Liver Int."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Lin, S., and Zhang, Y.-J. (2017). Interference of Apoptosis by Hepatitis B Virus. Viruses, 9.","DOI":"10.3390\/v9080230"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"37440","DOI":"10.1038\/s41598-025-21273-2","article-title":"Identification of key biomarkers associated with necroptosis and immune infiltration in hepatitis B virus-related acute-on-chronic liver failure","volume":"15","author":"Cao","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"101612","DOI":"10.1016\/j.jcmgh.2025.101612","article-title":"Targeting Ferroptosis Restores the Antiviral Activity of CD8(+) T Cells During Chronic Hepatitis B Virus Infection","volume":"19","author":"Li","year":"2025","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/s41419-025-08019-8","article-title":"Hepatic steatosis and pyroptosis are induced by the hepatitis B virus X protein via B56\u03b1-METTL3 interaction-mediated m6A modification of the NLRP3 mRNA","volume":"16","author":"Du","year":"2025","journal-title":"Cell Death Dis."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Lin, Y., Zhao, Z., Huang, A., and Lu, M. (2020). Interplay between Cellular Autophagy and Hepatitis B Virus Replication: A Systematic Review. Cells, 9.","DOI":"10.3390\/cells9092101"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1515\/hsz-2015-0172","article-title":"Hepatitis C virus and autophagy","volume":"396","author":"Wang","year":"2015","journal-title":"Biol. Chem."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Wallace, H.L., Wang, L., Gardner, C.L., Corkum, C.P., Grant, M.D., Hirasawa, K., and Russell, R.S. (2022). Crosstalk Between Pyroptosis and Apoptosis in Hepatitis C Virus-induced Cell Death. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.788138"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"4865","DOI":"10.3748\/wjg.v13.i36.4865","article-title":"Hepatitis C virus infection and apoptosis","volume":"13","author":"Fischer","year":"2007","journal-title":"World J. Gastroenterol."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"381","DOI":"10.2147\/JIR.S385977","article-title":"The Emerging Role of Ferroptosis in Various Chronic Liver Diseases: Opportunity or Challenge","volume":"16","author":"Zhu","year":"2023","journal-title":"J. Inflamm. Res."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1089\/vim.2023.0138","article-title":"Inflammatory Consequences: Hepatitis C Virus-Induced Inflammasome Activation and Pyroptosis","volume":"37","author":"Wallace","year":"2024","journal-title":"Viral Immunol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.3390\/cimb43030139","article-title":"Inflammation and Liver Cell Death in Patients with Hepatitis C Viral Infection","volume":"43","author":"Neuman","year":"2021","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Teschke, R., and Eickhoff, A. (2024). Wilson Disease: Copper-Mediated Cuproptosis, Iron-Related Ferroptosis, and Clinical Highlights, with Comprehensive and Critical Analysis Update. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25094753"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3892\/ijmm.2025.5558","article-title":"Role and mechanisms of cuproptosis in the pathogenesis of Wilson\u2019s disease (Review)","volume":"56","author":"Chen","year":"2025","journal-title":"Int. J. Mol. Med."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/nm1539","article-title":"Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide","volume":"13","author":"Lang","year":"2007","journal-title":"Nat. Med."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3892\/ijo.2024.5651","article-title":"Ferroptosis, pyroptosis and necroptosis in hepatocellular carcinoma immunotherapy: Mechanisms and immunologic landscape (Review)","volume":"64","author":"Liu","year":"2024","journal-title":"Int. J. Oncol."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/s41420-024-02116-x","article-title":"Programmed cell death in hepatocellular carcinoma: Mechanisms and therapeutic prospects","volume":"10","author":"Wu","year":"2024","journal-title":"Cell Death Discov."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1055\/s-0030-1267540","article-title":"Apoptosis as a mechanism for liver disease progression","volume":"30","author":"Guicciardi","year":"2010","journal-title":"Semin. Liver Dis."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"e996","DOI":"10.1038\/cddis.2013.499","article-title":"Molecular mechanisms of hepatic apoptosis","volume":"5","author":"Wang","year":"2014","journal-title":"Cell Death Dis."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/S0168-8278(02)00209-X","article-title":"Death receptor-mediated apoptosis and the liver","volume":"37","author":"Yoon","year":"2002","journal-title":"J. Hepatol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.3748\/wjg.v24.i25.2661","article-title":"Apoptosis and non-alcoholic fatty liver diseases","volume":"24","author":"Kanda","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1080\/20014091084182","article-title":"Apoptosis in diseases of the liver","volume":"38","author":"Neuman","year":"2001","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1097\/00042737-200107000-00005","article-title":"Apoptosis in liver disease","volume":"13","author":"Schuchmann","year":"2001","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41580-024-00703-5","article-title":"The cell biology of ferroptosis","volume":"25","author":"Dixon","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/s10637-021-01070-0","article-title":"System Xc(-): A key regulatory target of ferroptosis in cancer","volume":"39","author":"Liu","year":"2021","journal-title":"Investig. New Drugs"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1038\/s41401-024-01336-2","article-title":"The regulation and function of Nrf2 signaling in ferroptosis-activated cancer therapy","volume":"45","author":"Jiang","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"39542","DOI":"10.1038\/s41598-025-23180-y","article-title":"NCOA4-mediated ferroptosis conducive to EMT inhibition in colorectal cancer cells was achieved through the PI3K\/AKT\/mTOR pathway","volume":"15","author":"Fu","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/s41419-022-05027-w","article-title":"TFRC upregulation promotes ferroptosis in CVB3 infection via nucleus recruitment of Sp1","volume":"13","author":"Yi","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Jia, B., Li, J., Song, Y., and Luo, C. (2023). ACSL4-Mediated Ferroptosis and Its Potential Role in Central Nervous System Diseases and Injuries. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241210021"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s42003-025-07641-8","article-title":"Activation of gut metabolite ACSL4\/LPCAT3 by microplastics in drinking water mediates ferroptosis via gut\u2013kidney axis","volume":"8","author":"Zhang","year":"2025","journal-title":"Commun. Biol."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","article-title":"Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications","volume":"185","author":"Stockwell","year":"2022","journal-title":"Cell"},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Gensluckner, S., Wernly, B., Datz, C., and Aigner, E. (2024). Iron, Oxidative Stress, and Metabolic Dysfunction-Associated Steatotic Liver Disease. Antioxidants, 13.","DOI":"10.3390\/antiox13020208"},{"key":"ref_183","doi-asserted-by":"crossref","unstructured":"Park, G.C., Bang, S.Y., Kim, J.M., Shin, S.C., Cheon, Y.I., Kim, K.M., Park, H., Sung, E.S., Lee, M., and Lee, J.C. (2024). Inhibiting Ferroptosis Prevents the Progression of Steatotic Liver Disease in Obese Mice. Antioxidants, 13.","DOI":"10.20944\/preprints202410.1737.v1"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"24417","DOI":"10.1021\/acs.jafc.4c04929","article-title":"Nuciferine Alleviates High-Fat Diet- and ApoE\u2212\/\u2212-Induced Hepatic Steatosis and Ferroptosis in NAFLD Mice via the PPAR\u03b1 Signaling Pathway","volume":"72","author":"Qiu","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref_185","doi-asserted-by":"crossref","unstructured":"Li, C., Deng, D., Jiang, Q., Shi, J., Xu, L., and Liu, Y. (2025). Ferroptosis in NAFLD: Insights and the therapeutic potential of exercise. Front. Med., 12.","DOI":"10.3389\/fmed.2025.1462145"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1007\/s00109-025-02599-w","article-title":"Involvement of ferroptosis in metabolic dysfunction-associated steatohepatitis-related liver diseases","volume":"103","author":"Liu","year":"2025","journal-title":"J. Mol. Med."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"105088","DOI":"10.1016\/j.ebiom.2024.105088","article-title":"Emerging role of ferroptosis in metabolic dysfunction-associated steatotic liver disease: Revisiting hepatic lipid peroxidation","volume":"102","author":"Peleman","year":"2024","journal-title":"eBioMedicine"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1038\/s41418-024-01348-9","article-title":"Ferroptosis is a targetable detrimental factor in metabolic dysfunction-associated steatotic liver disease","volume":"31","author":"Peleman","year":"2024","journal-title":"Cell Death Differ."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.7150\/ijms.62903","article-title":"Ferroptosis and Liver Fibrosis","volume":"18","author":"Pan","year":"2021","journal-title":"Int. J. Med. Sci."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"10512","DOI":"10.3748\/wjg.v22.i48.10512","article-title":"Liver fibrosis and hepatic stellate cells: Etiology, pathological hallmarks and therapeutic targets","volume":"22","author":"Zhang","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s10565-025-10111-w","article-title":"Ferroptosis in liver fibrosis and its potential intervention strategy","volume":"41","author":"Zhu","year":"2025","journal-title":"Cell Biol. Toxicol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41419-022-04775-z","article-title":"Interaction between macrophages and ferroptosis","volume":"13","author":"Yang","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev-pathol-052016-100247","article-title":"Necroptosis: Mechanisms and Relevance to Disease","volume":"12","author":"Galluzzi","year":"2017","journal-title":"Annu. Rev. Pathol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"117196","DOI":"10.1016\/j.biopha.2024.117196","article-title":"Recognition of necroptosis: From molecular mechanisms to detection methods","volume":"178","author":"Zhu","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41420-025-02423-x","article-title":"Exploring necroptosis: Mechanistic analysis and antitumor potential of nanomaterials","volume":"11","author":"Dong","year":"2025","journal-title":"Cell Death Discov."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/s41586-019-1770-6","article-title":"Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis","volume":"575","author":"Fritsch","year":"2019","journal-title":"Nature"},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Xiao, H., Han, Z., Xu, M., Gao, X., Qiu, S., Ren, N., Yi, Y., and Zhou, C. (2025). The Role of Post-Translational Modifications in Necroptosis. Biomolecules, 15.","DOI":"10.3390\/biom15040549"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.tcb.2017.05.007","article-title":"Apoptosis and Necroptosis as Host Defense Strategies to Prevent Viral Infection","volume":"27","author":"Orzalli","year":"2017","journal-title":"Trends Cell Biol."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41419-023-05691-6","article-title":"The double-edged functions of necroptosis","volume":"14","author":"Ye","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.livres.2019.09.003","article-title":"Necroptosis in ischemia-reperfusion injury of lean and steatotic livers","volume":"3","author":"Sun","year":"2019","journal-title":"Liver Res."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"e13512","DOI":"10.1111\/acel.13512","article-title":"Necroptosis contributes to chronic inflammation and fibrosis in aging liver","volume":"20","author":"Mohammed","year":"2021","journal-title":"Aging Cell"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"5820","DOI":"10.7150\/thno.76902","article-title":"Multiple functions of MLKL in liver fibrosis, from necroptosis to hepatic stellate cell activation","volume":"12","author":"Pistorio","year":"2022","journal-title":"Theranostics"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/s41420-023-01749-8","article-title":"Programmed cell death in hepatic fibrosis: Current and perspectives","volume":"9","author":"Lu","year":"2023","journal-title":"Cell Death Discov."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"10471","DOI":"10.1007\/s11033-023-08857-9","article-title":"Targeting necroptosis in fibrosis","volume":"50","author":"Hassanein","year":"2023","journal-title":"Mol. Biol. Rep."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1007\/s11357-024-01418-3","article-title":"The role of inflammation induced by necroptosis in the development of fibrosis and liver cancer in novel knockin mouse models fed a western diet","volume":"47","author":"Selvarani","year":"2025","journal-title":"GeroScience"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41420-025-02579-6","article-title":"Pyroptosis, a double-edged sword during pathogen infection: A review","volume":"11","author":"Zhang","year":"2025","journal-title":"Cell Death Discov."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41392-021-00507-5","article-title":"Pyroptosis: Mechanisms and diseases","volume":"6","author":"Yu","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41577-019-0228-2","article-title":"The gasdermins, a protein family executing cell death and inflammation","volume":"20","author":"Broz","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41392-024-01958-2","article-title":"Pyroptosis in health and disease: Mechanisms, regulation and clinical perspective","volume":"9","author":"Liu","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_210","doi-asserted-by":"crossref","unstructured":"Resta, S.C., Guerra, F., Tal\u00e0, A., Bucci, C., and Alifano, P. (2024). Beyond Inflammation: Role of Pyroptosis Pathway Activation by Gram-Negative Bacteria and Their Outer Membrane Vesicles (OMVs) in the Interaction with the Host Cell. Cells, 13.","DOI":"10.3390\/cells13211758"},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"113006","DOI":"10.1016\/j.intimp.2024.113006","article-title":"Inflammation unleashed: The role of pyroptosis in chronic liver diseases","volume":"141","author":"Zhu","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"ref_212","doi-asserted-by":"crossref","unstructured":"Negrin, K.A., Roth Flach, R.J., DiStefano, M.T., Matevossian, A., Friedline, R.H., Jung, D., Kim, J.K., and Czech, M.P. (2014). IL-1 signaling in obesity-induced hepatic lipogenesis and steatosis. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0107265"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1089\/aid.2020.0177","article-title":"Pro-Inflammatory Interleukin-18 is Associated with Hepatic Steatosis and Elevated Liver Enzymes in People with HIV Monoinfection","volume":"37","author":"Sim","year":"2021","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"ref_214","doi-asserted-by":"crossref","unstructured":"Somm, E., and Jornayvaz, F.R. (2022). Interleukin-18 in metabolism: From mice physiology to human diseases. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.971745"},{"key":"ref_215","doi-asserted-by":"crossref","unstructured":"Hohenester, S., Kanitz, V., Schiergens, T., Einer, C., Nagel, J., Wimmer, R., Reiter, F.P., Gerbes, A.L., De Toni, E.N., and Bauer, C. (2020). IL-18 But Not IL-1 Signaling Is Pivotal for the Initiation of Liver Injury in Murine Non-Alcoholic Fatty Liver Disease. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21228602"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"G1324","DOI":"10.1152\/ajpgi.90564.2008","article-title":"Interleukin-1 participates in the progression from liver injury to fibrosis","volume":"296","author":"Gieling","year":"2009","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.jhep.2011.01.048","article-title":"Lack of interleukin-1\u03b1 or interleukin-1\u03b2 inhibits transformation of steatosis to steatohepatitis and liver fibrosis in hypercholesterolemic mice","volume":"55","author":"Kamari","year":"2011","journal-title":"J. Hepatol."},{"key":"ref_218","doi-asserted-by":"crossref","unstructured":"Zhang, Z., Wang, J., Li, H., Niu, Q., Tao, Y., Zhao, X., Zeng, Z., and Dong, H. (2025). The role of the interleukin family in liver fibrosis. Front. Immunol., 16.","DOI":"10.3389\/fimmu.2025.1497095"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1002\/hep.32776","article-title":"Interleukin-18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis","volume":"77","author":"Knorr","year":"2023","journal-title":"Hepatology"},{"key":"ref_220","doi-asserted-by":"crossref","unstructured":"Yang, S., Zou, Y., Zhong, C., Zhou, Z., Peng, X., and Tang, C. (2025). Dual role of pyroptosis in liver diseases: Mechanisms, implications, and therapeutic perspectives. Front. Cell Dev. Biol., 13.","DOI":"10.3389\/fcell.2025.1522206"},{"key":"ref_221","first-page":"e07790","article-title":"Risk assessment for Birds and Mammals","volume":"21","author":"Authority","year":"2023","journal-title":"EFSA J."},{"key":"ref_222","doi-asserted-by":"crossref","first-page":"114655","DOI":"10.1016\/j.ecoenv.2023.114655","article-title":"Ferroptosis contribute to neonicotinoid imidacloprid-evoked pyroptosis by activating the HMGB1-RAGE\/TLR4-NF-\u03baB signaling pathway","volume":"253","author":"Zhang","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"107789","DOI":"10.1016\/j.toxicon.2024.107789","article-title":"Protective effects of dietary additive quercetin: Nephrotoxicity and ferroptosis induced by avermectin pesticide","volume":"246","author":"Xiang","year":"2024","journal-title":"Toxicon"},{"key":"ref_224","doi-asserted-by":"crossref","first-page":"105655","DOI":"10.1016\/j.tiv.2023.105655","article-title":"Paraquat-induced ferroptosis suppression via NRF2 expression regulation","volume":"92","author":"Cai","year":"2023","journal-title":"Toxicol. Vitr."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"9249","DOI":"10.1007\/s11033-023-08756-z","article-title":"Molecular mechanism of paraquat-induced ferroptosis leading to pulmonary fibrosis mediated by Keap1\/Nrf2 signaling pathway","volume":"50","author":"Yang","year":"2023","journal-title":"Mol. Biol. Rep."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s12964-024-01520-1","article-title":"Regulation of NCOA4-mediated iron recycling ameliorates paraquat-induced lung injury by inhibiting ferroptosis","volume":"22","author":"Du","year":"2024","journal-title":"Cell Commun. Signal."},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.jare.2025.05.064","article-title":"Squalene epoxidase promotes paraquat-induced pulmonary toxicity through endoplasmic reticulum-mediated ferroptosis","volume":"81","author":"Zhu","year":"2025","journal-title":"J. Adv. Res."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"9603271231167585","DOI":"10.1177\/09603271231167585","article-title":"Treatment with paraquat affects the expression of ferroptosis-related genes","volume":"42","author":"Ge","year":"2023","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_229","doi-asserted-by":"crossref","first-page":"9961628","DOI":"10.1155\/2021\/9961628","article-title":"Ferritinophagy-Mediated Ferroptosis Involved in Paraquat-Induced Neurotoxicity of Dopaminergic Neurons: Implication for Neurotoxicity in PD","volume":"2021","author":"Zuo","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_230","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.tox.2019.02.011","article-title":"NADPH oxidase regulates paraquat and maneb-induced dopaminergic neurodegeneration through ferroptosis","volume":"417","author":"Hou","year":"2019","journal-title":"Toxicology"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1021\/acschemneuro.2c00308","article-title":"Mitochondrial Inhibitor Rotenone Triggers and Enhances Neuronal Ferroptosis Following Intracerebral Hemorrhage","volume":"14","author":"Cheng","year":"2023","journal-title":"ACS Chem. Neurosci."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"111763","DOI":"10.1016\/j.cbi.2025.111763","article-title":"Rotenone induces ferroptosis and neurotoxicity through inhibition of SIRT1-Nrf2-ferroportin 1\/GPX4 pathways in SH-SY5Y cells and mice","volume":"421","author":"Liu","year":"2025","journal-title":"Chem. Biol. Interact."},{"key":"ref_233","doi-asserted-by":"crossref","first-page":"9271","DOI":"10.1007\/s12035-025-04824-6","article-title":"ROS Regulate Rotenone-induced SH-SY5Y Dopamine Neuron Death Through Ferroptosis-mediated Autophagy and Apoptosis","volume":"62","author":"Li","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.7150\/ijms.74569","article-title":"Rotenone, an environmental toxin, causes abnormal methylation of the mouse brain organoid\u2019s genome and ferroptosis","volume":"19","author":"Huang","year":"2022","journal-title":"Int. J. Med. Sci."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"9694","DOI":"10.1007\/s12035-024-04140-5","article-title":"Bifenthrin Caused Parkinson\u2019s-Like Symptoms Via Mitochondrial Autophagy and Ferroptosis Pathway Stereoselectively in Parkin(-\/-) Mice and C57BL\/6 Mice","volume":"61","author":"Zhang","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"117729","DOI":"10.1016\/j.ecoenv.2025.117729","article-title":"Maternal exposure to deltamethrin during pregnancy and lactation impairs hippocampal learning and memory function of male offspring by ferroptosis","volume":"290","author":"Huang","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"128413","DOI":"10.1016\/j.chemosphere.2020.128413","article-title":"Tetrachlorobenzoquinone exposure triggers ferroptosis contributing to its neurotoxicity","volume":"264","author":"Liu","year":"2021","journal-title":"Chemosphere"},{"key":"ref_238","doi-asserted-by":"crossref","unstructured":"Linjacki, S., Wang, Y., Baath, N., Mantle, D., and Yang, G. (2024). H2S Protects from Rotenone-Induced Ferroptosis by Stabilizing Fe-S Clusters in Rat Cardiac Cells. Cells, 13.","DOI":"10.3390\/cells13050371"},{"key":"ref_239","doi-asserted-by":"crossref","unstructured":"Liu, Y., He, Y., Chen, M., Sun, Q., Zhang, B., Zhang, G., Cao, A., Li, Q., Wang, W., and Ju, S. (2025). Alpha-Tocopherol Protects Porcine Oocytes from Acetamiprid-Induced Meiotic Defects by Alleviating Oxidative Stress-Mediated Ferroptosis. Antioxidants, 14.","DOI":"10.3390\/antiox14111304"},{"key":"ref_240","doi-asserted-by":"crossref","first-page":"0860","DOI":"10.34133\/research.0860","article-title":"AMPK-ULK1-Mediated Ferritinophagy Drives Ferroptosis in GLA-Induced Testicular Toxicity","volume":"8","author":"Wang","year":"2025","journal-title":"Research"},{"key":"ref_241","doi-asserted-by":"crossref","first-page":"101601","DOI":"10.1016\/j.gendis.2025.101601","article-title":"Chlorpyrifos induces spermatogenic dysfunction via ferroptosis in Sertoli cells","volume":"12","author":"Fu","year":"2025","journal-title":"Genes Dis."},{"key":"ref_242","doi-asserted-by":"crossref","first-page":"106450","DOI":"10.1016\/j.pestbp.2025.106450","article-title":"Dietary supplementation of Lactobacillus casei alleviates permethrin exposure-induced zebrafish testis damage through modulation of TLR4\/NF-\u03baB and AKT\/Nrf2 pathways: Oxidative stress, inflammation and ferroptosis","volume":"212","author":"Huo","year":"2025","journal-title":"Pestic. Biochem. Physiol."},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"105935","DOI":"10.1016\/j.pestbp.2024.105935","article-title":"Protective effect of melatonin on imidacloprid-induced pyroptosis and ferroptosis by mediating peptidoglycan in the gut of the common carp (Cyprinus carpio)","volume":"202","author":"Miao","year":"2024","journal-title":"Pestic. Biochem. Physiol."},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"106142","DOI":"10.1016\/j.pestbp.2024.106142","article-title":"Investigating the role of the ROS\/CncC-xenobiotics signaling pathway in the response to Fenpropathrin in Cyprinus carpio lymphocytes: Involving lipid peroxidation and Fe2+ metabolism imbalance","volume":"205","author":"Diao","year":"2024","journal-title":"Pestic. Biochem. Physiol."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"e371","DOI":"10.1038\/oncsis.2017.65","article-title":"Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis","volume":"6","author":"Fan","year":"2017","journal-title":"Oncogenesis"},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"630","DOI":"10.20892\/j.issn.2095-3941.2019.0158","article-title":"The crosstalk between autophagy and ferroptosis: What can we learn to target drug resistance in cancer?","volume":"16","author":"Zhou","year":"2019","journal-title":"Cancer Biol. Med."},{"key":"ref_247","doi-asserted-by":"crossref","first-page":"107162","DOI":"10.1016\/j.phrs.2024.107162","article-title":"The interplay between autophagy and ferroptosis presents a novel conceptual therapeutic framework for neuroendocrine prostate cancer","volume":"203","author":"Wang","year":"2024","journal-title":"Pharmacol. Res."},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/s41419-023-05978-8","article-title":"Autophagy mediates an amplification loop during ferroptosis","volume":"14","author":"Lee","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_249","doi-asserted-by":"crossref","unstructured":"Chaouhan, H.S., Vinod, C., Mahapatra, N., Yu, S.-H., Wang, I.-K., Chen, K.-B., Yu, T.-M., and Li, C.-Y. (2022). Necroptosis: A Pathogenic Negotiator in Human Diseases. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232112714"},{"key":"ref_250","doi-asserted-by":"crossref","first-page":"119417","DOI":"10.1016\/j.bbamcr.2022.119417","article-title":"Rotenone induced neurodegeneration is mediated via cytoskeleton degradation and necroptosis","volume":"1870","author":"Roy","year":"2023","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"ref_251","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.fsi.2022.09.024","article-title":"Paraquat induces apoptosis, programmed necrosis, and immune dysfunction in CIK cells via the PTEN\/PI3K\/AKT axis","volume":"130","author":"Shi","year":"2022","journal-title":"Fish. Shellfish Immunol."},{"key":"ref_252","doi-asserted-by":"crossref","unstructured":"\u00d6zta\u015f, E., Kara, M., Boran, T., Bi\u015firir, E., Karaman, E.F., Kaptan, E., and \u00d6zhan, G. (2021). Cellular Stress Pathways Are Linked to Acetamiprid-Induced Apoptosis in SH-SY5Y Neural Cells. Biology, 10.","DOI":"10.3390\/biology10090820"},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.fsi.2020.11.007","article-title":"Resveratrol relieves chlorothalonil-induced apoptosis and necroptosis through miR-15a\/Bcl2-A20 axis in fish kidney cells","volume":"107","author":"Li","year":"2020","journal-title":"Fish. Shellfish. Immunol."},{"key":"ref_254","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1007\/s12012-017-9441-z","article-title":"Necrostatin-1 Protects Against Paraquat-Induced Cardiac Contractile Dysfunction via RIP1-RIP3-MLKL-Dependent Necroptosis Pathway","volume":"18","author":"Zhang","year":"2018","journal-title":"Cardiovasc. Toxicol."},{"key":"ref_255","doi-asserted-by":"crossref","first-page":"138714","DOI":"10.1016\/j.chemosphere.2023.138714","article-title":"Effects of Dichlorvos on cardiac cells: Toxicity and molecular mechanism of action","volume":"330","author":"Boussabbeh","year":"2023","journal-title":"Chemosphere"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1002\/tox.24097","article-title":"Resveratrol alleviates imidacloprid-induced mitochondrial apoptosis, necroptosis, and immune dysfunction in chicken lymphocyte lines by inhibiting the ROS\/MAPK signaling pathway","volume":"39","author":"Wang","year":"2024","journal-title":"Environ. Toxicol."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"108929","DOI":"10.1016\/j.fsi.2023.108929","article-title":"Micro-algal astaxanthin improves lambda-cyhalothrin-induced necroptosis and inflammatory responses via the ROS-mediated NF-\u03baB signaling in lymphocytes of carp (Cyprinus carpio L.)","volume":"139","author":"Cai","year":"2023","journal-title":"Fish. Shellfish Immunol."},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2131\/jts.43.193","article-title":"Necrosis in human neuronal cells exposed to paraquat","volume":"43","author":"Hirayama","year":"2018","journal-title":"J. Toxicol. Sci."},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"116869","DOI":"10.1016\/j.taap.2024.116869","article-title":"Fenpropathrin provoked kidney damage via controlling the NLRP3\/Caspase-1\/GSDMD\u2013mediated pyroptosis: The palliative role of curcumin-loaded chitosan nanoparticles","volume":"484","author":"Mohamed","year":"2024","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_260","doi-asserted-by":"crossref","first-page":"110873","DOI":"10.1016\/j.cbi.2024.110873","article-title":"Mitochondrial reactive oxygen species initiate gasdermin D-mediated pyroptosis and contribute to paraquat-induced nephrotoxicity","volume":"390","author":"Chen","year":"2024","journal-title":"Chem. Biol. Interact."},{"key":"ref_261","first-page":"95","article-title":"Hesperidin Alleviates Malathion-Induced nephrotoxicity in Rats: Impact on Oxidative Damage, Inflammation, Pyroptosis and Apoptosis","volume":"45","author":"Saati","year":"2025","journal-title":"Bull. Egypt. Soc. Physiol. Sci."},{"key":"ref_262","doi-asserted-by":"crossref","first-page":"113608","DOI":"10.1016\/j.intimp.2024.113608","article-title":"Pyroptosis mediated by Parkin-NLRP3 negative feedback loop contributed to Parkinson\u2019s disease induced by rotenone","volume":"143","author":"Zheng","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"ref_263","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000511207","article-title":"Suppression of NLRP3 Inflammasome, Pyroptosis, and Cell Death by NIM811 in Rotenone-Exposed Cells as an in vitro Model of Parkinson\u2019s Disease","volume":"20","author":"Zhang","year":"2020","journal-title":"Neurodegener. Dis."},{"key":"ref_264","doi-asserted-by":"crossref","first-page":"115154","DOI":"10.1016\/j.ecoenv.2023.115154","article-title":"Herbicide propisochlor exposure induces intestinal barrier impairment, microbiota dysbiosis and gut pyroptosis","volume":"262","author":"Liu","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_265","doi-asserted-by":"crossref","first-page":"10574","DOI":"10.1021\/acs.jafc.5c01019","article-title":"New Insights into Melatonin\u2019s Function on Thiacloprid-Induced Pyroptosis and Inflammatory Response in Head Kidney Lymphocytes of Cyprinus carpio: Implicating Mitochondrial Metabolic Imbalance and mtROS\/cGAS-STING\/NF-\u03baB Axis","volume":"73","author":"Diao","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"174558","DOI":"10.1016\/j.scitotenv.2024.174558","article-title":"Abamectin-induced behavioral alterations link to energy metabolism disorder and ferroptosis via oxidative stress in Chinese mitten crab, Eriocheir sinensis","volume":"947","author":"Huang","year":"2024","journal-title":"Sci. Total Environ."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"117747","DOI":"10.1016\/j.ecoenv.2025.117747","article-title":"Effects of pesticide dichlorvos on liver injury in rats and related toxicity mechanisms","volume":"290","author":"Zhang","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"105830","DOI":"10.1016\/j.pestbp.2024.105830","article-title":"Chlorantraniliprole induces mitophagy, ferroptosis, and cytokine homeostasis imbalance in grass carp (Ctenopharyngodon idella) hepatocytes via the mtROS-mitochondrial fission\/fusion axis","volume":"200","author":"Shi","year":"2024","journal-title":"Pestic. Biochem. Physiol."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"160839","DOI":"10.1016\/j.scitotenv.2022.160839","article-title":"Glyphosate-triggered hepatocyte ferroptosis via suppressing Nrf2\/GSH\/GPX4 axis exacerbates hepatotoxicity","volume":"862","author":"Liu","year":"2023","journal-title":"Sci. Total Environ."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.bbrc.2016.09.042","article-title":"Deltamethrin induced RIPK3-mediated caspase-independent non-apoptotic cell death in rat primary hepatocytes","volume":"479","author":"Arora","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"109551","DOI":"10.1016\/j.cbpc.2023.109551","article-title":"Tannin alleviates glyphosate exposure-induced apoptosis, necrosis and immune dysfunction in hepatic L8824 cell line by inhibiting ROS\/PTEN\/PI3K\/AKT pathway","volume":"266","author":"Zhang","year":"2023","journal-title":"Comp. Biochem. Physiol. Part. C Toxicol. Pharmacol."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"106030","DOI":"10.1016\/j.pestbp.2024.106030","article-title":"A new insight into the mechanism of dichlorodiphenyltrichloroethane-induced hepatotoxicity based on GSDME-mediated pyroptosis","volume":"204","author":"Tan","year":"2024","journal-title":"Pestic. Biochem. Physiol."},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"110179","DOI":"10.1016\/j.intimp.2023.110179","article-title":"Imidacloprid activates Kupffer cells pyroptosis to induce liver injury in mice via P2 \u00d7 7","volume":"119","author":"Pei","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1006\/taap.2000.9066","article-title":"Effects of Iron Overload and Lindane Intoxication in Relation to Oxidative Stress, Kupffer Cell Function, and Liver Injury in the Rat","volume":"170","author":"Junge","year":"2001","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"116245","DOI":"10.1016\/j.taap.2022.116245","article-title":"Perinatal exposure to a glyphosate pesticide formulation induces offspring liver damage","volume":"454","author":"Rieg","year":"2022","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_276","doi-asserted-by":"crossref","first-page":"102349","DOI":"10.1016\/j.redox.2022.102349","article-title":"Ethyl carbamate triggers ferroptosis in liver through inhibiting GSH synthesis and suppressing Nrf2 activation","volume":"53","author":"Xu","year":"2022","journal-title":"Redox Biol."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.toxrep.2023.12.004","article-title":"Carbamate compounds induced toxic effects by affecting Nrf2 signaling pathways","volume":"12","author":"Nasrabadi","year":"2024","journal-title":"Toxicol. Rep."},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"20","DOI":"10.5009\/gnl18486","article-title":"Cell Death and Liver Disease","volume":"14","author":"Aizawa","year":"2020","journal-title":"Gut Liver"}],"container-title":["Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-9721\/14\/3\/96\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T14:52:39Z","timestamp":1772722359000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-9721\/14\/3\/96"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,5]]},"references-count":278,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["diseases14030096"],"URL":"https:\/\/doi.org\/10.3390\/diseases14030096","relation":{},"ISSN":["2079-9721"],"issn-type":[{"value":"2079-9721","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,5]]}}}