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Endothelial dysfunction, oxidative stress, plaque progression, and thrombosis are all facilitated by inflammatory signaling in ASCVD. Similar pathways are known to contribute to cancer growth and invasion. Emerging epidemiologic data demonstrate increased cancer incidence among patients with cardiovascular disease, while cancer survivors and recipients of cardiotoxic therapies exhibit accelerated vascular disease. This narrative review aims to describe the bidirectional relationship between ASCVD and cancer. Targeting shared pathways using statins, colchicine, canakinumab, IL-6 inhibition, and lifestyle modification may provide dual benefits. Future biomarker-guided trials with integrated cardiovascular and oncologic endpoints are needed to clarify causality and optimize prevention and management.<\/jats:p>","DOI":"10.3390\/diseases14070237","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T10:04:44Z","timestamp":1782986684000},"page":"237","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Inflammation-Mediated Bidirectional Relationship Between Cardiovascular Disease and Cancer"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1801-1272","authenticated-orcid":false,"given":"Shahzaib","family":"Chughtai","sequence":"first","affiliation":[{"name":"College of Medicine, Central Michigan University, 1632 Stone St, Saginaw, MI 48602, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shofikur","family":"Shuhag","sequence":"additional","affiliation":[{"name":"Henry Ford St. John, 22101 Moross Rd, Detroit, MI 48236, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6855-3193","authenticated-orcid":false,"given":"Daksh","family":"Saksena","sequence":"additional","affiliation":[{"name":"Johns Hopkins Medicine, 600 N. Wolfe Street, Baltimore, MD 21231, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9082-9768","authenticated-orcid":false,"given":"Manum","family":"Zaman","sequence":"additional","affiliation":[{"name":"Fatima Memorial Hospital College of Medicine and Dentistry, Shadman Rd, Ichhra Lahore 54000, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4581-3980","authenticated-orcid":false,"given":"Muhammad Usman","family":"Ghani","sequence":"additional","affiliation":[{"name":"MyMichigan Medical Center, 800 S. Washington Avenue, Saginaw, MI 48601, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"#cr-split#-ref_1.1","unstructured":"(2025). Global Burden of Cardiovascular Diseases"},{"key":"#cr-split#-ref_1.2","unstructured":"Risks 2023 Collaborators. 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